Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis

• Published in: Journal of allergy and clinical immunology Vol. 128; no. 1; pp. 242 - 246.e5
• Main Authors: De Benedetto, Anna, Slifka, Mark K., Rafaels, Nicholas M., Kuo, I-Hsin, Georas, Steve N., Boguniewicz, Mark, Hata, Tissa, Schneider, Lynda C., Hanifin, Jon M., Gallo, Richard L., Johnson, David C., Barnes, Kathleen C., Leung, Donald Y.M., Beck, Lisa A.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.07.2011; Elsevier; Elsevier Limited
• Subjects: Adult; Allergic diseases; Allergy and Immunology; Biological and medical sciences; Cells, Cultured; Claudin-1; Dermatitis, Atopic - complications; Dermatitis, Atopic - genetics; Dermatitis, Atopic - microbiology; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Genetic Predisposition to Disease; Haplotypes; Humans; Immunopathology; Infections; Kaposi Varicelliform Eruption - genetics; Keratinocytes - metabolism; Male; Medical sciences; Membrane Proteins - genetics; Mutation; Permeability; Polymorphism, Single Nucleotide; Proteins; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Skin allergic diseases. Stinging insect allergies; Tight Junctions - metabolism; Young Adult; Claudin 1; Allergy; Immunopathology; Skin disease; Herpesviridae; Alphaherpesvirinae; Atopy; Virus; Infection; Sensitivity; Immunology; Atopic dermatitis; Human herpesvirus 1
• ISSN: 0091-6749; 1097-6825; 1097-6825
• DOI: 10.1016/j.jaci.2011.02.014

To the Editor: Atopic dermatitis (AD) is the most common inflammatory skin disease, affecting up to 20% of children in the United States, and is characterized by an increased susceptibility to cutaneous infections.1,2 One in 10 subjects with AD has difficulty clearing cutaneous infections with a host of viruses including herpes simplex, vaccinia, human papilloma, and/or molluscum contagiosum.1 This typically manifests as more extensive cutaneous and sometimes systemic disease and/or resistance to standard therapies.