The broad-spectrum antiviral functions of IFIT and IFITM proteins

• Published in: Nature reviews. Immunology Vol. 13; no. 1; pp. 46 - 57
• Main Authors: Diamond, Michael S., Farzan, Michael
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2013; Nature Publishing Group
• Subjects: Adaptive immunity; Amino Acid Sequence; Animals; Antigens, Differentiation - genetics; Antigens, Differentiation - immunology; Antiviral Agents - immunology; Biomedical and Life Sciences; Biomedicine; Carrier Proteins - genetics; Carrier Proteins - immunology; Cytokines; Genes; Genetic aspects; Genetic transcription; Health aspects; Humans; Immunology; Infections; Interferon; Interferon Inducers - immunology; Interferons - genetics; Interferons - immunology; Kinases; Melanoma; Membrane proteins; Models, Immunological; Molecular Sequence Data; Pathogens; Physiological aspects; Proteins; review-article; Sequence Homology, Amino Acid; Signal transduction; Signal Transduction - immunology; Viral infections; Virus Diseases - immunology; Viruses; Viruses - immunology; Viruses - pathogenicity; United States; United States > US

Key Points IFN-induced protein with tetratricopeptide repeats (IFIT) proteins — which are induced after type I interferon (IFN)- or IFN-regulatory factor 3 (IRF3)-dependent signalling — contribute to antiviral defence against some viruses by binding to components of the eukaryotic initiation factor...