HER2 expression, copy number variation and survival outcomes in HER2-low non-metastatic breast cancer: an international multicentre cohort study and TCGA-METABRIC analysis

• Published in: BMC Medicine Vol. 20; no. 1; pp. 105 - 15
• Main Authors: Tan, Ryan Shea Ying Cong, Ong, Whee Sze, Lee, Kyung-Hun, Lim, Abner Herbert, Park, Seri, Park, Yeon Hee, Lin, Ching-Hung, Lu, Yen-Shen, Ono, Makiko, Ueno, Takayuki, Naito, Yoichi, Onishi, Tatsuya, Lim, Geok-Hoon, Tan, Su-Ming, Lee, Han-Byoel, Ryu, Han Suk, Han, Wonshik, Tan, Veronique Kiak Mien, Wong, Fuh-Yong, Im, Seock-Ah, Tan, Puay Hoon, Chan, Jason Yongsheng, Yap, Yoon-Sim
• Format: Journal Article
• Language: English
• Published: England Springer Science and Business Media LLC 17.03.2022; BioMed Central Ltd; BioMed Central; BMC
• Subjects: Analysis; Breast cancer; Breast Neoplasms; Breast Neoplasms - pathology; Care and treatment; Cohort Studies; Copy number variations; Diagnosis; DNA Copy Number Variations; DNA Copy Number Variations - genetics; ERBB2 neutral; Female; HER2-low breast cancer; Humans; Medicine; METABRIC; Neoplasm Recurrence, Local; Prognosis; R; Research Article; Risk factors; TCGA; Singapore; ERBB2 neutral; Prognosis; HER2-low breast cancer; METABRIC; TCGA

HER2-low breast cancer (BC) is currently an area of active interest. This study evaluated the impact of low expression of HER2 on survival outcomes in HER2-negative non-metastatic breast cancer (BC). Patients with HER2-negative non-metastatic BC from 6 centres within the Asian Breast Cancer Cooperat...