A pigtailed macaque model of Kyasanur Forest disease virus and Alkhurma hemorrhagic disease virus pathogenesis

• Published in: PLoS pathogens Vol. 17; no. 12; p. e1009678
• Main Authors: Broeckel, Rebecca M, Feldmann, Friederike, McNally, Kristin L, Chiramel, Abhilash I, Sturdevant, Gail L, Leung, Jacqueline M, Hanley, Patrick W, Lovaglio, Jamie, Rosenke, Rebecca, Scott, Dana P, Saturday, Greg, Bouamr, Fadila, Rasmussen, Angela L, Robertson, Shelly J, Best, Sonja M
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.12.2021; Public Library of Science (PLoS)
• Subjects: Animal models; Animal models in research; Animals; Antiviral agents; Appetite; Appetite loss; Arachnids; Biology and life sciences; Brain research; Chlorocebus aethiops; Clotting; Cytokines - blood; Dehydration; Development and progression; Diarrhea; Disease Models, Animal; Encephalitis; Encephalitis Viruses, Tick-Borne - genetics; Encephalitis Viruses, Tick-Borne - immunology; Encephalitis Viruses, Tick-Borne - pathogenicity; Encephalitis, Tick-Borne - immunology; Encephalitis, Tick-Borne - pathology; Encephalitis, Tick-Borne - virology; Female; Fever; Gastrointestinal symptoms; Gastrointestinal system; Gastrointestinal tract; Gene expression; Health risks; HEK293 Cells; Hemorrhage; Hemorrhagic disease; Hemorrhagic fever; Hemorrhagic Fevers, Viral - immunology; Hemorrhagic Fevers, Viral - pathology; Hemorrhagic Fevers, Viral - virology; Humans; Illnesses; Infections; Infectious diseases; Inoculation; Lymph Nodes - virology; Lymphopenia; Macaca nemestrina; Macaques; Medicine and Health Sciences; Pathogenesis; Physiological aspects; Proteins; Public health; Thrombocytopenia; Tropism; Vaccines; Vero Cells; Viremia; Viruses; Vomiting; United States; India

Kyasanur Forest disease virus (KFDV) and the closely related Alkhurma hemorrhagic disease virus (AHFV) are emerging flaviviruses that cause severe viral hemorrhagic fevers in humans. Increasing geographical expansion and case numbers, particularly of KFDV in southwest India, class these viruses as a...