Molecular constraints on synaptic tagging and maintenance of long-term potentiation: a predictive model

• Published in: PLoS computational biology Vol. 8; no. 8; p. e1002620
• Main Authors: Smolen, Paul, Baxter, Douglas A, Byrne, John H
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.08.2012; Public Library of Science (PLoS)
• Subjects: Biology; Computational biology; Experiments; Feedback; Hippocampus (Brain); Humans; Kinases; Long-Term Potentiation; Mathematics; Models, Biological; Molecular dynamics; Neurosciences; Physiological aspects; Protein biosynthesis; Protein Kinase C - metabolism; Protein synthesis; Proteins; Stochastic Processes; Synapses - enzymology; Synapses - physiology; Tetanus; United States; Stochastic Processes; Models, Biological; Humans; Synapses; Long-Term Potentiation; Protein Kinase C

Protein synthesis-dependent, late long-term potentiation (LTP) and depression (LTD) at glutamatergic hippocampal synapses are well characterized examples of long-term synaptic plasticity. Persistent increased activity of protein kinase M ζ (PKMζ) is thought essential for maintaining LTP. Additional...