Phytophthora methylomes are modulated by 6mA methyltransferases and associated with adaptive genome regions

• Published in: Genome Biology Vol. 19; no. 1; p. 181
• Main Authors: Chen, Han, Shu, Haidong, Wang, Liyuan, Zhang, Fan, Li, Xi, Ochola, Sylvans Ochieng, Mao, Fei, Ma, Hongyu, Ye, Wenwu, Gu, Tingting, Jiang, Lubin, Wu, Yufeng, Wang, Yuanchao, Kamoun, Sophien, Dong, Suomeng
• Format: Journal Article
• Language: English
• Published: England BioMed Central 31.10.2018; BMC
• Subjects: 5-methylcytosine; Adaptive genome; Adenine; Chromatography; Deoxyribonucleic acid; DNA; DNA Methylation; DNA sequencing; Enzymatic activity; Enzymes; Epigenetics; Evolution; Evolution & development; evolutionary adaptation; Famine; Fungi; Gene expression; Gene Expression Regulation; genes; Genome; Genomes; Genomics; Glycine max - parasitology; Insects; Localization; Mammals; Methyltransferases; Methyltransferases - metabolism; mutants; N6-methyladenosine; Nematodes; Pathogens; Phylogeny; Phytophthora; Phytophthora - classification; Phytophthora - enzymology; Phytophthora - genetics; Phytophthora infestans; Phytophthora sojae; plant pathogens; Prokaryotes; Proteins; Stem cells; Transcription; Virulence; DNA methylation; Phytophthora; Methyltransferases; Adaptive genome

Filamentous plant pathogen genomes often display a bipartite architecture with gene-sparse, repeat-rich compartments serving as a cradle for adaptive evolution. The extent to which this two-speed genome architecture is associated with genome-wide DNA modifications is unknown. We show that the oomyce...