NS2B/NS3 mutations enhance the infectivity of genotype I Japanese encephalitis virus in amplifying hosts

• Published in: PLoS pathogens Vol. 15; no. 8; p. e1007992
• Main Authors: Fan, Yi-Chin, Liang, Jian-Jong, Chen, Jo-Mei, Lin, Jen-Wei, Chen, Yi-Ying, Su, Kuan-Hsuan, Lin, Chang-Chi, Tu, Wu-Chun, Chiou, Ming-Tang, Ou, Shan-Chia, Chang, Gwong-Jen J., Lin, Yi-Ling, Chiou, Shyan-Song
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.08.2019; Public Library of Science (PLoS)
• Subjects: Amplification; Animals; Aquatic insects; Biology and Life Sciences; Chickens; Culex; Development and progression; Encephalitis; Encephalitis Virus, Japanese - genetics; Encephalitis Virus, Japanese - pathogenicity; Encephalitis, Japanese - epidemiology; Encephalitis, Japanese - genetics; Encephalitis, Japanese - virology; Epidemics; Female; Gene mutation; Genes; Genetic aspects; Genotype; Genotypes; Health aspects; High temperature; Hogs; Host-virus relationships; Infection; Infectivity; Japanese encephalitis; Juveniles; Medicine and Health Sciences; Mosquito Vectors; Mosquitoes; Mutation; Poultry; Preventive medicine; Replication; RNA Helicases - genetics; Serine Endopeptidases - genetics; Swine; Vaccines; Vector-borne diseases; Viral genetics; Viral Nonstructural Proteins - genetics; Viremia; Viremia - transmission; Virus diseases; Virus Replication; Viruses; Zika virus; Taiwan; United States > US

Genotype I (GI) virus has replaced genotype III (GIII) virus as the dominant Japanese encephalitis virus (JEV) in the epidemic area of Asia. The mechanism underlying the genotype replacement remains unclear. Therefore, we focused our current study on investigating the roles of mosquito vector and am...