Focused ultrasound modulates region-specific brain activity

• Published in: NeuroImage (Orlando, Fla.) Vol. 56; no. 3; pp. 1267 - 1275
• Main Authors: Yoo, Seung-Schik, Bystritsky, Alexander, Lee, Jong-Hwan, Zhang, Yongzhi, Fischer, Krisztina, Min, Byoung-Kyong, McDannold, Nathan J., Pascual-Leone, Alvaro, Jolesz, Ferenc A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2011; Elsevier Limited
• Subjects: Acoustics; Animals; Blood-Brain Barrier; Body Temperature; Brain - physiology; Brain - radiation effects; Brain Mapping; Electrophysiological Phenomena; Magnetic Resonance Imaging; Male; Medical research; Motor Cortex - physiology; Motor Cortex - radiation effects; NMR; Nuclear magnetic resonance; Rabbits; Somatosensory Cortex - physiology; Somatosensory Cortex - radiation effects; Transducers; Ultrasonic imaging; Ultrasonics; Visual Cortex - physiology; Visual Cortex - radiation effects

We demonstrated the in vivo feasibility of using focused ultrasound (FUS) to transiently modulate (through either stimulation or suppression) the function of regional brain tissue in rabbits. FUS was delivered in a train of pulses at low acoustic energy, far below the cavitation threshold, to the an...