Biogenesis and molecular characteristics of serum hepatitis B virus RNA

• Published in: PLoS pathogens Vol. 16; no. 10; p. e1008945
• Main Authors: Shen, Sheng, Xie, Zhanglian, Cai, Dawei, Yu, Xiaoyang, Zhang, Hu, Kim, Elena S., Zhou, Bin, Hou, Jinlin, Zhang, Xiaoyong, Huang, Qi, Sun, Jian, Guo, Haitao
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.10.2020; Public Library of Science (PLoS)
• Subjects: Assembly; Biological markers; Biology and Life Sciences; Biomarkers; Cancer; Capsid - metabolism; Capsid Proteins - metabolism; Capsids; Cell culture; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA, Viral - genetics; Egress; Encapsidation; Funding; Genetic aspects; Genomes; Health aspects; Hepatitis; Hepatitis B; Hepatitis B virus; Hepatitis B virus - metabolism; Hepatitis B virus - pathogenicity; Hepatocytes; Hepatocytes - virology; Hospitals; Humans; Identification and classification; Immunology; Infections; Infectious diseases; Life cycles; Medicine; Medicine and health sciences; Modulators; Molecular biology; Morphogenesis; Mutants; Northern blotting; Poly(A); Polyadenine; Polymerase chain reaction; Priming; Research and analysis methods; Reverse transcription; Reverse Transcription - genetics; Ribonuclease; Ribonucleic acid; RNA; RNA polymerase; RNA viruses; RNA, Viral - genetics; Supervision; Virions; Virulence (Microbiology); Virus Assembly - genetics; Virus Replication - genetics; Virus-like particles; Viruses; China; South San Francisco California; Pittsburgh Pennsylvania; Indiana; United States > US; Indianapolis Indiana

HBV is an enveloped DNA virus that replicates its DNA genome via reverse transcription of a pregenomic (pg) RNA intermediate in hepatocytes. Interestingly, HBV RNA can be detected in virus-like particles in chronic hepatitis B (CHB) patient serum and has been utilized as a biomarker for intrahepatic...