Schistosome immunomodulators

• Published in: PLoS pathogens Vol. 17; no. 12; p. e1010064
• Main Authors: Acharya, Sreemoyee, Da’dara, Akram A., Skelly, Patrick J.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.12.2021; Public Library of Science (PLoS)
• Subjects: Addition polymerization; Adenosine; Adenosine diphosphate; Animals; Apoptosis; Bacterial proteins; Biology and Life Sciences; Biomolecules; Bone marrow; Care and treatment; Causes of; Cytokines; Drug development; Eggs; Eicosanoids; Extracellular vesicles; Females; Gene expression; Glycan; Health aspects; Helminth Proteins - immunology; Histamine; Humans; Immune response; Immune system; Immunity; Immunologic Factors - immunology; Immunomodulation; Immunomodulators; Immunoregulation; Infections; Ligands; Lipids; Lymphocytes; Lymphocytes B; Lymphocytes T; Macrophages; Medicine and Health Sciences; Metabolism; Metabolites; miRNA; Molecular modelling; Nucleic acids; Parasites; Parasitic diseases; Polymers; Polyps; Polysaccharides; Prostaglandin E2; Protein arrays; Proteins; Research and Analysis Methods; Review; Schistosoma - immunology; Schistosomiasis; Schistosomiasis - immunology; Skin; Sphingosine 1-phosphate; Tropical diseases; Tumor necrosis factor-TNF; Worms; United States

Schistosomes are long lived, intravascular parasitic platyhelminths that infect >200 million people globally. The molecular mechanisms used by these blood flukes to dampen host immune responses are described in this review. Adult worms express a collection of host-interactive tegumental ectoenzym...