Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014
Middle East respiratory syndrome coronavirus (MERS-CoV) causes a spectrum of illness. We evaluated whether cycle threshold (Ct) values (which are inversely related to virus load) were associated with clinical severity in patients from Saudi Arabia whose nasopharyngeal specimens tested positive for t...
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| Published in | Emerging infectious diseases Vol. 21; no. 11; pp. 2029 - 2035 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
U.S. National Center for Infectious Diseases
01.11.2015
Centers for Disease Control and Prevention |
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| Abstract | Middle East respiratory syndrome coronavirus (MERS-CoV) causes a spectrum of illness. We evaluated whether cycle threshold (Ct) values (which are inversely related to virus load) were associated with clinical severity in patients from Saudi Arabia whose nasopharyngeal specimens tested positive for this virus by real-time reverse transcription PCR. Among 102 patients, median Ct of 31.0 for the upstream of the E gene target for 41 (40%) patients who died was significantly lower than the median of 33.0 for 61 survivors (p=0.0087). In multivariable regression analyses, risk factors for death were age>60 years), underlying illness, and decreasing Ct for each 1-point decrease in Ct). Results were similar for a composite severe outcome (death and/or intensive care unit admission). More data are needed to determine whether modulation of virus load by therapeutic agents affects clinical outcomes. |
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| AbstractList | More data are needed to determine whether modulation of virus load by therapeutic agents affects clinical outcomes.
Middle East respiratory syndrome coronavirus (MERS-CoV) causes a spectrum of illness. We evaluated whether cycle threshold (C
t
) values (which are inversely related to virus load) were associated with clinical severity in patients from Saudi Arabia whose nasopharyngeal specimens tested positive for this virus by real-time reverse transcription PCR. Among 102 patients, median C
t
of 31.0 for the upstream of the E gene target for 41 (40%) patients who died was significantly lower than the median of 33.0 for 61 survivors (p = 0.0087). In multivariable regression analyses, risk factors for death were age >60 years), underlying illness, and decreasing C
t
for each 1-point decrease in C
t
). Results were similar for a composite severe outcome (death and/or intensive care unit admission). More data are needed to determine whether modulation of virus load by therapeutic agents affects clinical outcomes. Middle East respiratory syndrome coronavirus (MERS-CoV) causes a spectrum of illness. We evaluated whether cycle threshold (Ct) values (which are inversely related to virus load) were associated with clinical severity in patients from Saudi Arabia whose nasopharyngeal specimens tested positive for this virus by real-time reverse transcription PCR. Among 102 patients, median Ct of 31.0 for the upstream of the E gene target for 41 (40%) patients who died was significantly lower than the median of 33.0 for 61 survivors (p=0.0087). In multivariable regression analyses, risk factors for death were age>60 years), underlying illness, and decreasing Ct for each 1-point decrease in Ct). Results were similar for a composite severe outcome (death and/or intensive care unit admission). More data are needed to determine whether modulation of virus load by therapeutic agents affects clinical outcomes. |
| Audience | Professional Academic |
| Author | Shabouni, Omaima Tomczyk, Sara M. Oboho, Ikwo K. Wolff, Bernard Feikin, Daniel R. Qutub, Mohammed Alraddadi, Basem Watson, John T. Curns, Aaron Madani, Tariq A. |
| Author_xml | – sequence: 1 givenname: Daniel R. surname: Feikin fullname: Feikin, Daniel R. – sequence: 2 givenname: Basem surname: Alraddadi fullname: Alraddadi, Basem – sequence: 3 givenname: Mohammed surname: Qutub fullname: Qutub, Mohammed – sequence: 4 givenname: Omaima surname: Shabouni fullname: Shabouni, Omaima – sequence: 5 givenname: Aaron surname: Curns fullname: Curns, Aaron – sequence: 6 givenname: Ikwo K. surname: Oboho fullname: Oboho, Ikwo K. – sequence: 7 givenname: Sara M. surname: Tomczyk fullname: Tomczyk, Sara M. – sequence: 8 givenname: Bernard surname: Wolff fullname: Wolff, Bernard – sequence: 9 givenname: John T. surname: Watson fullname: Watson, John T. – sequence: 10 givenname: Tariq A. surname: Madani fullname: Madani, Tariq A. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26488195$$D View this record in MEDLINE/PubMed |
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| Keywords | Saudi Arabia Middle East respiratory syndrome coronavirus zoonoses viruses MERS-CoV virus load |
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| Snippet | Middle East respiratory syndrome coronavirus (MERS-CoV) causes a spectrum of illness. We evaluated whether cycle threshold (Ct) values (which are inversely... More data are needed to determine whether modulation of virus load by therapeutic agents affects clinical outcomes. Middle East respiratory syndrome... |
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| SubjectTerms | Adolescent Adult Aged Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014 Child Coronavirus - genetics Coronavirus - immunology Coronavirus Infections - epidemiology Coronavirus Infections - immunology Coronavirus Infections - mortality Coronavirus Infections - virology Expedited Female Humans Male Measurement Medical research Medicine, Experimental MERS-CoV Middle Aged Middle East respiratory syndrome coronavirus Prognosis Saudi Arabia Saudi Arabia - epidemiology Viremia virus load viruses zoonoses |
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| Title | Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014 |
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