Global and Local Architecture of the Mammalian microRNA–Transcription Factor Regulatory Network

• Published in: PLoS computational biology Vol. 3; no. 7; p. e131
• Main Authors: Shalgi, Reut, Lieber, Daniel, Oren, Moshe, Pilpel, Yitzhak
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.07.2007; Public Library of Science (PLoS)
• Subjects: Algorithms; Animals; Base Sequence; Binding Sites; Computational Biology; Conserved Sequence; Feedback, Physiological; Gene expression; Gene Expression - physiology; Gene Expression Profiling; Gene Expression Regulation - genetics; Gene Regulatory Networks; Genes, Regulator - genetics; Genetics; Genetics and Genomics; Genomes; Homo (Human); Humans; Mammals; Mammals - genetics; MicroRNAs - analysis; MicroRNAs - metabolism; Promoter Regions, Genetic; Proteins; Signal Transduction - genetics; Transcription Factors - analysis; Transcription Factors - metabolism; Promoter Regions, Genetic; Gene Expression; Signal Transduction; Humans; Gene Expression Regulation; Gene Expression Profiling; Gene Regulatory Networks; Mammals; Feedback, Physiological; Algorithms; Animals; Base Sequence; MicroRNAs; Genes, Regulator; Conserved Sequence; Transcription Factors; Binding Sites

microRNAs (miRs) are small RNAs that regulate gene expression at the posttranscriptional level. It is anticipated that, in combination with transcription factors (TFs), they span a regulatory network that controls thousands of mammalian genes. Here we set out to uncover local and global architectura...