Dietary fructose-induced gut dysbiosis promotes mouse hippocampal neuroinflammation: a benefit of short-chain fatty acids - Li, Jian-Mei; Yu, Rong; Zhang, Li-Ping; Wen, Shi-Yu; Wang, Shui-Juan; Zhang, Xiao-Yang; Xu, Qiang; Kong, Ling-Dong (Microbiome, 2019)
Keywords: Analysis; Animal behavior; Animals; Antibiotics; Bacteria; Carcinoma; Cognitive ability; Colon; Colon cancer; Colorectal cancer; Dextran; Dextrans; Diet; Dietary fiber; Dietary supplements; Digestive system; Doublecortin protein; Dysbacteriosis; Dysbiosis - chemically induced; Emotional behavior; Explants; Fatty acids; Fatty Acids, Volatile - administration & dosage; Fructose; Fructose - adverse effects; Gastrointestinal Microbiome; Gastrointestinal tract; Genetic aspects; Gliosis; Gut dysbiosis; Health aspects; Hippocampus; Hippocampus - drug effects; Hippocampus - pathology; Histamine; Homeostasis; House mouse; Inflammasomes; Inflammation; Inflammation - chemically induced; Inflammatory bowel disease; Intestinal microflora; Intestinal Mucosa - drug effects; Intestinal Mucosa - microbiology; Intestine; Male; Metabolites; Metronidazole; Mice; Mice, Inbred C57BL; Microbiota; Microbiota (Symbiotic organisms); Monosaccharides; Neomycin; Nervous system diseases; Neurodegenerative diseases; Neuroimmunomodulation - drug effects; Neuroinflammation; Neuronal loss; Neurons; Newborn infants; NLRP6 inflammasome; Oxidative stress; Peroxisome proliferator-activated receptors; Pioglitazone; Pioglitazone - administration & dosage; Polysaccharides; Pyrin protein; Short-chain fatty acids; siRNA; Tumor necrosis factor-TNF; Short-chain fatty acids; Neuroinflammation; Neuronal loss; Gut dysbiosis; NLRP6 inflammasome