Novel Thogotovirus Associated with Febrile Illness and Death, United States, 2014

• Published in: Emerging infectious diseases Vol. 21; no. 5; pp. 760 - 764
• Main Authors: Kosoy, Olga I., Lambert, Amy J., Hawkinson, Dana J., Pastula, Daniel M., Goldsmith, Cynthia S., Hunt, D. Charles, Staples, J. Erin
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.05.2015; Centers for Disease Control and Prevention
• Subjects: Analysis; Autopsy; Bourbon virus; Cladistic analysis; Expedited; Fatal Outcome; Fever - diagnosis; Fever - drug therapy; Fever - epidemiology; Fever - virology; Genome, Viral; Heartland virus; high-throughput nucleotide sequencing; Humans; Influenza, Human - diagnosis; Influenza, Human - drug therapy; Influenza, Human - epidemiology; Influenza, Human - virology; Kansas - epidemiology; Male; Middle Aged; neutralization tests; Novel; Phylogeny; RNA, Viral; Species Associated with Febrile Illness and Death, United States, 2014; Thogotovirus; Thogotovirus - classification; Thogotovirus - genetics; Thogotovirus - isolation & purification; Thogotovirus - ultrastructure; viruses; Kansas; Heartland virus; Bourbon virus; viruses; death; United States; Kansas; high-throughput nucleotide sequencing; neutralization tests; Thogotovirus; febrile illness

A previously healthy man from eastern Kansas, USA, sought medical care in late spring because of a history of tick bite, fever, and fatigue. The patient had thrombocytopenia and leukopenia and was given doxycycline for a presumed tickborne illness. His condition did not improve. Multiorgan failure d...