Novel Thogotovirus Associated with Febrile Illness and Death, United States, 2014
A previously healthy man from eastern Kansas, USA, sought medical care in late spring because of a history of tick bite, fever, and fatigue. The patient had thrombocytopenia and leukopenia and was given doxycycline for a presumed tickborne illness. His condition did not improve. Multiorgan failure d...
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| Published in | Emerging infectious diseases Vol. 21; no. 5; pp. 760 - 764 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
U.S. National Center for Infectious Diseases
01.05.2015
Centers for Disease Control and Prevention |
| Subjects | |
| Online Access | Get full text |
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| Abstract | A previously healthy man from eastern Kansas, USA, sought medical care in late spring because of a history of tick bite, fever, and fatigue. The patient had thrombocytopenia and leukopenia and was given doxycycline for a presumed tickborne illness. His condition did not improve. Multiorgan failure developed, and he died 11 days after illness onset from cardiopulmonary arrest. Molecular and serologic testing results for known tickborne pathogens were negative. However, testing of a specimen for antibodies against Heartland virus by using plaque reduction neutralization indicated the presence of another virus. Next-generation sequencing and phylogenetic analysis identified the virus as a novel member of the genus Thogotovirus. |
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| AbstractList | A previously healthy man from eastern Kansas, USA, sought medical care in late spring because of a history of tick bite, fever, and fatigue. The patient had thrombocytopenia and leukopenia and was given doxycycline for a presumed tickborne illness. His condition did not improve. Multiorgan failure developed, and he died 11 days after illness onset from cardiopulmonary arrest. Molecular and serologic testing results for known tickborne pathogens were negative. However, testing of a specimen for antibodies against Heartland virus by using plaque reduction neutralization indicated the presence of another virus. Next-generation sequencing and phylogenetic analysis identified the virus as a novel member of the genus Thogotovirus.A previously healthy man from eastern Kansas, USA, sought medical care in late spring because of a history of tick bite, fever, and fatigue. The patient had thrombocytopenia and leukopenia and was given doxycycline for a presumed tickborne illness. His condition did not improve. Multiorgan failure developed, and he died 11 days after illness onset from cardiopulmonary arrest. Molecular and serologic testing results for known tickborne pathogens were negative. However, testing of a specimen for antibodies against Heartland virus by using plaque reduction neutralization indicated the presence of another virus. Next-generation sequencing and phylogenetic analysis identified the virus as a novel member of the genus Thogotovirus. A previously healthy man from eastern Kansas, USA, sought medical care in late spring because of a history of tick bite, fever, and fatigue. The patient had thrombocytopenia and leukopenia and was given doxycycline for a presumed tickborne illness. His condition did not improve. Multiorgan failure developed, and he died 11 days after illness onset from cardiopulmonary arrest. Molecular and serologic testing results for known tickborne pathogens were negative. However, testing of a specimen for antibodies against Heartland virus by using plaque reduction neutralization indicated the presence of another virus. Next-generation sequencing and phylogenetic analysis identified the virus as a novel member of the genus Thogotovirus. Bourbon virus is a newly discovered pathogen associated with human illness and death. A previously healthy man from eastern Kansas, USA, sought medical care in late spring because of a history of tick bite, fever, and fatigue. The patient had thrombocytopenia and leukopenia and was given doxycycline for a presumed tickborne illness. His condition did not improve. Multiorgan failure developed, and he died 11 days after illness onset from cardiopulmonary arrest. Molecular and serologic testing results for known tickborne pathogens were negative. However, testing of a specimen for antibodies against Heartland virus by using plaque reduction neutralization indicated the presence of another virus. Next-generation sequencing and phylogenetic analysis identified the virus as a novel member of the genus Thogotovirus . |
| Audience | Professional Academic |
| Author | Hawkinson, Dana J. Hunt, D. Charles Goldsmith, Cynthia S. Staples, J. Erin Pastula, Daniel M. Kosoy, Olga I. Lambert, Amy J. |
| Author_xml | – sequence: 1 givenname: Olga I. surname: Kosoy fullname: Kosoy, Olga I. – sequence: 2 givenname: Amy J. surname: Lambert fullname: Lambert, Amy J. – sequence: 3 givenname: Dana J. surname: Hawkinson fullname: Hawkinson, Dana J. – sequence: 4 givenname: Daniel M. surname: Pastula fullname: Pastula, Daniel M. – sequence: 5 givenname: Cynthia S. surname: Goldsmith fullname: Goldsmith, Cynthia S. – sequence: 6 givenname: D. Charles surname: Hunt fullname: Hunt, D. Charles – sequence: 7 givenname: J. Erin surname: Staples fullname: Staples, J. Erin |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25899080$$D View this record in MEDLINE/PubMed |
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| Keywords | Heartland virus Bourbon virus viruses death United States Kansas high-throughput nucleotide sequencing neutralization tests Thogotovirus febrile illness |
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| Snippet | A previously healthy man from eastern Kansas, USA, sought medical care in late spring because of a history of tick bite, fever, and fatigue. The patient had... Bourbon virus is a newly discovered pathogen associated with human illness and death. A previously healthy man from eastern Kansas, USA, sought medical care in... |
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| SubjectTerms | Analysis Autopsy Bourbon virus Cladistic analysis Expedited Fatal Outcome Fever - diagnosis Fever - drug therapy Fever - epidemiology Fever - virology Genome, Viral Heartland virus high-throughput nucleotide sequencing Humans Influenza, Human - diagnosis Influenza, Human - drug therapy Influenza, Human - epidemiology Influenza, Human - virology Kansas - epidemiology Male Middle Aged neutralization tests Novel Phylogeny RNA, Viral Species Associated with Febrile Illness and Death, United States, 2014 Thogotovirus Thogotovirus - classification Thogotovirus - genetics Thogotovirus - isolation & purification Thogotovirus - ultrastructure viruses |
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| Title | Novel Thogotovirus Associated with Febrile Illness and Death, United States, 2014 |
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