Congruent microbiome signatures in fibrosis-prone autoimmune diseases: IgG4-related disease and systemic sclerosis

• Published in: Genome medicine Vol. 13; no. 1; pp. 35 - 14
• Main Authors: Plichta, Damian R., Somani, Juhi, Pichaud, Matthieu, Wallace, Zachary S., Fernandes, Ana D., Perugino, Cory A., Lähdesmäki, Harri, Stone, John H., Vlamakis, Hera, Chung, Daniel C., Khanna, Dinesh, Pillai, Shiv, Xavier, Ramnik J.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.02.2021; BioMed Central; BMC
• Subjects: Analysis; Antibiotics; Antigens; Arthritis; Autoimmune diseases; Autoimmunity; B cells; Bacteroidetes - physiology; Care and treatment; Case-Control Studies; CD4 antigen; Clostridium; Cohort Studies; Colonization; Connective tissue; Cytotoxicity; Deoxyribonucleic acid; Development and progression; Digestive system; Disease; DNA; DNA sequencing; Extracellular matrix; Extracellular Matrix - metabolism; Fibronectin; Fibronectin-binding protein; Fibronectins; Fibrosis; Firmicutes - physiology; Gastrointestinal diseases; Gastrointestinal Microbiome; Gene set enrichment analysis; Genes; Genetic testing; Gut microbiome; Helper cells; Homocysteine; Humans; Hydroxyproline; IgG4-RD; Immune system; Immunoglobulin G; Immunoglobulin G4; Immunoglobulin G4-Related Disease - microbiology; Immunoglobulins; Inflammation; Inflammatory bowel diseases; Intestinal microflora; Intestine; Lymphocytes; Lymphocytes T; Metagenomics; Mevalonate pathway; Mevalonic acid; Microbiomes; Microbiota; Mucosa; Multiple sclerosis; Pathogenesis; Patients; Protein binding; Proteins; Rare diseases; Rheumatoid arthritis; Rheumatoid factor; Scleroderma; Scleroderma (Disease); Scleroderma, Systemic - microbiology; Signal Transduction; Species; Species Specificity; Systemic scleroderma; Systemic sclerosis; T cells; Autoimmunity; Gut microbiome; Systemic sclerosis; IgG4-RD

Immunoglobulin G4-related disease (IgG4-RD) and systemic sclerosis (SSc) are rare autoimmune diseases characterized by the presence of CD4+ cytotoxic T cells in the blood as well as inflammation and fibrosis in various organs, but they have no established etiologies. Similar to other autoimmune dise...