Brief communication: Vitamin D serum levels in American tegumentary leishmaniasis from an endemic area in Northeast Brazil

The pathogenesis of cutaneous and mucosal leishmaniasis is associated with different immune responses. Vitamin D may modulate the immune system. Here we evaluate the association of vitamin D levels with the severity of the clinical forms of cutaneous and mucosal leishmaniasis. We conducted an observ...

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Published in	The Brazilian journal of infectious diseases Vol. 27; no. 1; p. 102720
Main Authors	Figueiredo, Lorena Pinheiro, Cerqueira-Silva, Thiago, Magalhães, Andréa, Lago, Ednaldo Lima, Lessa, Marcus Miranda
Format	Journal Article
Language	English
Published	Brazil Elsevier España, S.L.U 01.01.2023 Contexto Elsevier Brazilian Society of Infectious Diseases
Subjects	Alfacalcidol Brazil - epidemiology Brief Communication Calcifediol Communication Cross-Sectional Studies Cutaneous leishmaniasis Development and progression Health aspects Humans Immune response INFECTIOUS DISEASES Leishmaniasis Leishmaniasis, Cutaneous Leishmaniasis, Cutaneous - epidemiology Leishmaniasis, Cutaneous - pathology Measurement Mucocutaneous leishmaniasis Risk factors United States Vitamin D Vitamin D Deficiency - epidemiology Brazil United States Cutaneous leishmaniasis Mucocutaneous leishmaniasis Leishmaniasis Vitamin D
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Abstract	The pathogenesis of cutaneous and mucosal leishmaniasis is associated with different immune responses. Vitamin D may modulate the immune system. Here we evaluate the association of vitamin D levels with the severity of the clinical forms of cutaneous and mucosal leishmaniasis. We conducted an observational study evaluating the association between vitamin D levels, disease severity and therapeutic response in patients with cutaneous and mucosal leishmaniasis. Additionally, we conducted a cross-sectional study to compare vitamin D levels in patients with leishmaniasis and healthy subjects. Hypovitaminosis D was defined as a serum level of 25 (OH) D < 30 ng/mL. In patients with leishmaniasis, vitamin D serum levels were 38.5 ± 11.54 ng/mL, and 37.5 ± 10.43 ng/mL in healthy subjects The prevalence of hypovitaminosis D was 23.3% and 20.0%, respectively (p = 0.72). There was no correlation between vitamin D serum levels, disease severity, and healing time in the mucosal leishmaniasis group. Vitamin D levels are not associated with neither susceptibility nor severity of tegumentary leishmaniasis.
AbstractList	The pathogenesis of cutaneous and mucosal leishmaniasis is associated with different immune responses. Vitamin D may modulate the immune system. Here we evaluate the association of vitamin D levels with the severity of the clinical forms of cutaneous and mucosal leishmaniasis. We conducted an observational study evaluating the association between vitamin D levels, disease severity and therapeutic response in patients with cutaneous and mucosal leishmaniasis. Additionally, we conducted a cross-sectional study to compare vitamin D levels in patients with leishmaniasis and healthy subjects. Hypovitaminosis D was defined as a serum level of 25 (OH) D < 30 ng/mL. In patients with leishmaniasis, vitamin D serum levels were 38.5 ± 11.54 ng/mL, and 37.5 ± 10.43 ng/mL in healthy subjects The prevalence of hypovitaminosis D was 23.3% and 20.0%, respectively (p = 0.72). There was no correlation between vitamin D serum levels, disease severity, and healing time in the mucosal leishmaniasis group. Vitamin D levels are not associated with neither susceptibility nor severity of tegumentary leishmaniasis. Abstract Introduction The pathogenesis of cutaneous and mucosal leishmaniasis is associated with different immune responses. Vitamin D may modulate the immune system. Here we evaluate the association of vitamin D levels with the severity of the clinical forms of cutaneous and mucosal leishmaniasis. Methods We conducted an observational study evaluating the association between vitamin D levels, disease severity and therapeutic response in patients with cutaneous and mucosal leishmaniasis. Additionally, we conducted a cross-sectional study to compare vitamin D levels in patients with leishmaniasis and healthy subjects. Hypovitaminosis D was defined as a serum level of 25 (OH) D < 30 ng/mL. Results In patients with leishmaniasis, vitamin D serum levels were 38.5 ± 11.54 ng/mL, and 37.5 ± 10.43 ng/mL in healthy subjects The prevalence of hypovitaminosis D was 23.3% and 20.0%, respectively (p = 0.72). There was no correlation between vitamin D serum levels, disease severity, and healing time in the mucosal leishmaniasis group. Conclusion Vitamin D levels are not associated with neither susceptibility nor severity of tegumentary leishmaniasis. Introduction: The pathogenesis of cutaneous and mucosal leishmaniasis is associated with different immune responses. Vitamin D may modulate the immune system. Here we evaluate the association of vitamin D levels with the severity of the clinical forms of cutaneous and mucosal leishmaniasis. Methods: We conducted an observational study evaluating the association between vitamin D levels, disease severity and therapeutic response in patients with cutaneous and mucosal leishmaniasis. Additionally, we conducted a cross-sectional study to compare vitamin D levels in patients with leishmaniasis and healthy subjects. Hypovitaminosis D was defined as a serum level of 25 (OH) D < 30 ng/mL. Results: In patients with leishmaniasis, vitamin D serum levels were 38.5 ± 11.54 ng/mL, and 37.5 ± 10.43 ng/mL in healthy subjects The prevalence of hypovitaminosis D was 23.3% and 20.0%, respectively (p = 0.72). There was no correlation between vitamin D serum levels, disease severity, and healing time in the mucosal leishmaniasis group. Conclusion: Vitamin D levels are not associated with neither susceptibility nor severity of tegumentary leishmaniasis. Introduction: The pathogenesis of cutaneous and mucosal leishmaniasis is associated with different immune responses. Vitamin D may modulate the immune system. Here we evaluate the association of vitamin D levels with the severity of the clinical forms of cutaneous and mucosal leishmaniasis. Methods: We conducted an observational study evaluating the association between vitamin D levels, disease severity and therapeutic response in patients with cutaneous and mucosal leishmaniasis. Additionally, we conducted a cross-sectional study to compare vitamin D levels in patients with leishmaniasis and healthy subjects. Hypovitaminosis D was defined as a serum level of 25 (OH) D < 30 ng/mL. Results: In patients with leishmaniasis, vitamin D serum levels were 38.5 [+ or -] 11.54 ng/mL, and 37.5 [+ or -] 10.43 ng/mL in healthy subjects The prevalence of hypovitaminosis D was 23.3% and 20.0%, respectively (p = 0.72). There was no correlation between vitamin D serum levels, disease severity, and healing time in the mucosal leishmaniasis group. Conclusion: Vitamin D levels are not associated with neither susceptibility nor severity of tegumentary leishmaniasis. The pathogenesis of cutaneous and mucosal leishmaniasis is associated with different immune responses. Vitamin D may modulate the immune system. Here we evaluate the association of vitamin D levels with the severity of the clinical forms of cutaneous and mucosal leishmaniasis.INTRODUCTIONThe pathogenesis of cutaneous and mucosal leishmaniasis is associated with different immune responses. Vitamin D may modulate the immune system. Here we evaluate the association of vitamin D levels with the severity of the clinical forms of cutaneous and mucosal leishmaniasis.We conducted an observational study evaluating the association between vitamin D levels, disease severity and therapeutic response in patients with cutaneous and mucosal leishmaniasis. Additionally, we conducted a cross-sectional study to compare vitamin D levels in patients with leishmaniasis and healthy subjects. Hypovitaminosis D was defined as a serum level of 25 (OH) D < 30 ng/mL.METHODSWe conducted an observational study evaluating the association between vitamin D levels, disease severity and therapeutic response in patients with cutaneous and mucosal leishmaniasis. Additionally, we conducted a cross-sectional study to compare vitamin D levels in patients with leishmaniasis and healthy subjects. Hypovitaminosis D was defined as a serum level of 25 (OH) D < 30 ng/mL.In patients with leishmaniasis, vitamin D serum levels were 38.5 ± 11.54 ng/mL, and 37.5 ± 10.43 ng/mL in healthy subjects The prevalence of hypovitaminosis D was 23.3% and 20.0%, respectively (p = 0.72). There was no correlation between vitamin D serum levels, disease severity, and healing time in the mucosal leishmaniasis group.RESULTSIn patients with leishmaniasis, vitamin D serum levels were 38.5 ± 11.54 ng/mL, and 37.5 ± 10.43 ng/mL in healthy subjects The prevalence of hypovitaminosis D was 23.3% and 20.0%, respectively (p = 0.72). There was no correlation between vitamin D serum levels, disease severity, and healing time in the mucosal leishmaniasis group.Vitamin D levels are not associated with neither susceptibility nor severity of tegumentary leishmaniasis.CONCLUSIONVitamin D levels are not associated with neither susceptibility nor severity of tegumentary leishmaniasis.
ArticleNumber	102720
Audience	Academic
Author	Lessa, Marcus Miranda Cerqueira-Silva, Thiago Magalhães, Andréa Figueiredo, Lorena Pinheiro Lago, Ednaldo Lima
AuthorAffiliation	Universidade Federal da Bahia
AuthorAffiliation_xml	– name: Universidade Federal da Bahia
Author_xml	– sequence: 1 givenname: Lorena Pinheiro orcidid: 0000-0002-2327-670X surname: Figueiredo fullname: Figueiredo, Lorena Pinheiro email: imuno@ufba.br organization: Universidade Federal da Bahia, Programa de Pós-Graduação em Ciências da Saúde, Salvador, BA, Brazil – sequence: 2 givenname: Thiago orcidid: 0000-0003-4534-2509 surname: Cerqueira-Silva fullname: Cerqueira-Silva, Thiago organization: Universidade Federal da Bahia, Programa de Pós-Graduação em Ciências da Saúde, Salvador, BA, Brazil – sequence: 3 givenname: Andréa surname: Magalhães fullname: Magalhães, Andréa organization: Universidade Federal da Bahia, Serviço de Imunologia do Hospital Universitário Professor Edgard Santos, Salvador, BA, Brazil – sequence: 4 givenname: Ednaldo Lima orcidid: 0000-0003-2231-197X surname: Lago fullname: Lago, Ednaldo Lima organization: Universidade Federal da Bahia, Serviço de Imunologia do Hospital Universitário Professor Edgard Santos, Salvador, BA, Brazil – sequence: 5 givenname: Marcus Miranda orcidid: 0000-0002-5003-0828 surname: Lessa fullname: Lessa, Marcus Miranda organization: Universidade Federal da Bahia, Serviço de Imunologia do Hospital Universitário Professor Edgard Santos, Salvador, BA, Brazil
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Cites_doi	10.1155/2012/134645 10.1016/j.exppara.2013.05.009 10.1186/s13098-016-0188-7 10.1128/IAI.02404-14 10.2174/1874192401509010040 10.1172/JCI111465 10.4049/jimmunol.167.9.4974 10.1016/j.trstmh.2012.03.007 10.4049/jimmunol.173.5.2909 10.1016/j.imlet.2005.06.004 10.1590/1414-431x20177185 10.1096/fj.06-7261com
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Keywords	Cutaneous leishmaniasis Mucocutaneous leishmaniasis Leishmaniasis Vitamin D
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publication-title: Open Cardiovasc Med J – volume: 125 start-page: 1704S issue: 6 Suppl year: 1995 end-page: 1708S article-title: Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functions publication-title: J Nutr – volume: 83 start-page: 898 year: 2015 end-page: 906 article-title: Protective and pathological functions of CD8+ T cells in Leishmania braziliensis infection publication-title: Infect Immun – volume: 51 start-page: 7185 year: 2018 article-title: Correlation between serum 25-hydroxyvitamin D levels and carotid intima-media thickness in a Brazilian population descended from African slaves publication-title: Braz J Med Biol Res – volume: 2012 start-page: 134645 year: 2012 article-title: The role of vitamin D and vitamin D receptor in immunity to leishmania major infection publication-title: J Parasitol Res – volume: 8 start-page: 77 year: 2016 article-title: Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus publication-title: Diabet Metabolic Syn – volume: 134 start-page: 413 year: 2013 end-page: 421 article-title: Effect of 1,25(OH)2D3 on BALB/c mice infected with Leishmania mexicana publication-title: Exp Parasitol – volume: 106 start-page: 376 year: 2012 end-page: 381 article-title: A proposed new clinical staging system for patients with mucosal leishmaniasis publication-title: Trans R Soc Trop Med Hyg – volume: 167 start-page: 4974 year: 2001 end-page: 4980 article-title: 1alpha, 25- dihydroxyvitamin D3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells publication-title: J Immunol – volume: 21 start-page: 3208 year: 2007 end-page: 3218 article-title: Vitamin D receptor signaling contributes to susceptibility to infection with Leishmania major publication-title: FASEB J
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Snippet	The pathogenesis of cutaneous and mucosal leishmaniasis is associated with different immune responses. Vitamin D may modulate the immune system. Here we... Introduction: The pathogenesis of cutaneous and mucosal leishmaniasis is associated with different immune responses. Vitamin D may modulate the immune system.... Abstract Introduction The pathogenesis of cutaneous and mucosal leishmaniasis is associated with different immune responses. Vitamin D may modulate the immune...
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SubjectTerms	Alfacalcidol Brazil - epidemiology Brief Communication Calcifediol Communication Cross-Sectional Studies Cutaneous leishmaniasis Development and progression Health aspects Humans Immune response INFECTIOUS DISEASES Leishmaniasis Leishmaniasis, Cutaneous Leishmaniasis, Cutaneous - epidemiology Leishmaniasis, Cutaneous - pathology Measurement Mucocutaneous leishmaniasis Risk factors United States Vitamin D Vitamin D Deficiency - epidemiology
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Title	Brief communication: Vitamin D serum levels in American tegumentary leishmaniasis from an endemic area in Northeast Brazil
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