Resistance to anti-EGFR therapies in metastatic colorectal cancer: underlying mechanisms and reversal strategies - Zhou, Jing; Ji, Qing; Li, Qi (Journal of experimental & clinical cancer research, 2021)
Keywords: Analysis; Animals; Anti-epidermal growth factor receptor targeted therapies; Antimitotic agents; Antineoplastic agents; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Cancer; Cancer therapies; Care and treatment; Cell growth; Clinical Decision-Making; Clinical Trials as Topic; Colorectal cancer; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - etiology; Colorectal Neoplasms - metabolism; Cytotoxicity; Development and progression; Disease Management; Drug Development; Drug resistance; Drug Resistance, Neoplasm - drug effects; Efficiency; Energy Metabolism - drug effects; Epidermal growth factor; ErbB Receptors - antagonists & inhibitors; ErbB Receptors - genetics; ErbB Receptors - metabolism; Feedback; Gene Amplification; Gene mutations; Genetic aspects; Health aspects; Humans; Insulin-like growth factors; Kinases; Ligands; Medical prognosis; Melanoma; Metabolism; Metastasis; Metastatic colorectal cancer; Microsatellite Instability; Molecular Targeted Therapy - adverse effects; Molecular Targeted Therapy - methods; Monoclonal antibodies; Mutation; Neovascularization, Pathologic - drug therapy; Neovascularization, Pathologic - etiology; Neovascularization, Pathologic - metabolism; Phosphorylation; Protein Binding; Protein Kinase Inhibitors - pharmacology; Protein Kinase Inhibitors - therapeutic use; Proteins; Reversal strategies; Review; Signal Transduction - drug effects; Treatment Outcome; Tumor Microenvironment - drug effects; Tumors; Vascular endothelial growth factor; Reversal strategies; Anti-epidermal growth factor receptor targeted therapies; Drug resistance; Metastatic colorectal cancer