Mechanisms and rejuvenation strategies for aged hematopoietic stem cells

• Published in: Journal of hematology and oncology Vol. 13; no. 1; pp. 31 - 16
• Main Authors: Li, Xia, Zeng, Xiangjun, Xu, Yulin, Wang, Binsheng, Zhao, Yanmin, Lai, Xiaoyu, Qian, Pengxu, Huang, He
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.04.2020; BioMed Central; BMC
• Subjects: Age; Aging; Analysis; Animals; B cells; Bias; Bone marrow; Cell cycle; Cell Self Renewal; Cellular Senescence; Cyclin-dependent kinases; Deoxyribonucleic acid; DNA; DNA damage; DNA repair; Epigenesis, Genetic; Epigenetic inheritance; Epigenetics; Gene expression; Genomes; Hematology; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Hematopoietic stem cells; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - metabolism; Homing behavior; Humans; Kinases; Molecular modelling; Mutation; Oncology; Proteins; Rejuvenation; Review; Reviews; Signal Transduction; Single-cell sequencing; Stem cell research; Stem cell transplantation; Stem cells; Transplants & implants; Canada; Aging; Epigenetics; Single-cell sequencing; Hematopoietic stem cells; Rejuvenation

Hematopoietic stem cell (HSC) aging, which is accompanied by reduced self-renewal ability, impaired homing, myeloid-biased differentiation, and other defects in hematopoietic reconstitution function, is a hot topic in stem cell research. Although the number of HSCs increases with age in both mice an...