Cleavage-Activation of Respiratory Viruses – Half a Century of History from Sendai Virus to SARS-CoV-2

• Published in: Japanese Journal of Infectious Diseases Vol. 77; no. 1; pp. 1 - 6
• Main Author: Takeda, Makoto
• Format: Journal Article
• Language: English
• Published: Japan National Institute of Infectious Diseases 31.01.2024; Japan Science and Technology Agency
• Subjects: Animals; Avian flu; Cleavage; Coronaviruses; COVID-19; Furin; Furin - metabolism; Hemagglutinins; Humans; Influenza; Membrane fusion; Membrane Fusion Proteins; Membranes; Newcastle disease; Pandemics; Peptide Hydrolases - metabolism; protease; Proteins; Respiratory diseases; SARS-CoV-2; SARS-CoV-2 - genetics; Sendai virus; Sendai virus - genetics; Sendai virus - metabolism; Severe acute respiratory syndrome coronavirus 2; Spike protein; TMPRSS2; Viral diseases; Virulence; Virus Internalization; Viruses; protease; TMPRSS2; SARS-CoV-2; cleavage; Sendai virus

Many viruses require the cleavage-activation of membrane fusion proteins by host proteases in the course of infection. This knowledge is based on historical studies of Sendai virus in the 1970s. From the 1970s to the 1990s, avian influenza virus and Newcastle disease virus were studied, showing a cl...