Liquid biopsy for detecting epidermal growth factor receptor mutation among patients with non-small cell lung cancer treated with afatinib: a multicenter prospective study

• Published in: BMC cancer Vol. 22; no. 1; pp. 1 - 11
• Main Authors: Fujii, Hiroaki, Nagakura, Hideyuki, Kobayashi, Nobuaki, Kubo, Sousuke, Tanaka, Katsushi, Watanabe, Keisuke, Horita, Nobuyuki, Hara, Yu, Nishikawa, Masanori, Miura, Kenji, Koizumi, Harumi, Ito, Yu, Tsubakihara, Motofumi, Miyazawa, Naoki, Kudo, Makoto, Shinkai, Masaharu, Kaneko, Takeshi
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 04.10.2022; BioMed Central; BMC
• Subjects: Adrenal glands; Analysis; Antimitotic agents; Antineoplastic agents; Biopsy; Cancer therapies; Care and treatment; Cell-free deoxyribonucleic acid; Diagnosis; Disease; Dosage and administration; Enzyme inhibitors; Epidermal growth factor; Epidermal growth factor receptor; Epidermal growth factor receptors; Gene mutations; Health aspects; Liquid biopsy; Lung cancer; Lung cancer, Non-small cell; Lungs; Metastases; Metastasis; Mutation; Non-small cell lung cancer; Non-small cell lung carcinoma; Patients; Prevention; Protein-tyrosine kinase; Risk factors; Second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors; Small cell lung carcinoma; Survival analysis; Tumors; Japan; United States > US

Background This study aimed to determine the effectiveness of liquid biopsy in detecting epidermal growth factor receptor (EGFR) mutations at diagnosis, disease progression, and intermediate stages. Methods This prospective, multicenter, observational study included 30 patients with non-small cell l...