The human gallbladder microbiome is related to the physiological state and the biliary metabolic profile

• Published in: Microbiome Vol. 7; no. 1; pp. 100 - 17
• Main Authors: Molinero, Natalia, Ruiz, Lorena, Milani, Christian, Gutiérrez-Díaz, Isabel, Sánchez, Borja, Mangifesta, Marta, Segura, José, Cambero, Isabel, Campelo, Ana Belén, García-Bernardo, Carmen María, Cabrera, Ana, Rodríguez, José Ignacio, González, Sonia, Rodríguez, Juan Miguel, Ventura, Marco, Delgado, Susana, Margolles, Abelardo
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.07.2019; BioMed Central; BMC
• Subjects: Adult; Aged; Bacteria; Bacteria - classification; Bile; Bile - metabolism; Bile - microbiology; Bile microbiota; Body mass index; Cholelithiasis; Cholesterol; Deoxyribonucleic acid; Diagnostic imaging; DNA; Ecosystems; Enzymes; Female; Gallbladder; Gallbladder - microbiology; Gallbladder - physiology; Gallstones; Gallstones patients; Genes; Genetic research; Genetic testing; Genomes; Humans; Intestine; Lithiasis; Lithiasis - microbiology; Liver; Liver diseases; Liver transplantation; Male; Medical research; Metabolism; Metabolites; Metabolomics; Metagenome; Microbial bile metabolites; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Middle Aged; NMR; Nuclear magnetic resonance; Obesity; Organ donors; Organ transplantation; Physiological aspects; Physiology; Polymerase chain reaction; RNA; RNA, Ribosomal, 16S - genetics; RNA, Ribosomal, 18S - genetics; rRNA 16S; Surgery; Gallstones patients; Microbial bile metabolites; Cholelithiasis; Bile microbiota

The microbial populations of the human intestinal tract and their relationship to specific diseases have been extensively studied during the last decade. However, the characterization of the human bile microbiota as a whole has been hampered by difficulties in accessing biological samples and the la...