Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season

• Published in: Nature Medicine Vol. 26; no. 12; pp. 1929 - 1940
• Main Authors: Andrade, Carolina M, Fleckenstein, Hannah, Thomson-Luque, Richard, Doumbo, Safiatou, Lima, Nathalia F, Anderson, Carrie, Hibbert, Julia, Hopp, Christine S, Tran, Tuan M, Li, Shanping, Niangaly, Moussa, Cisse, Hamidou, Doumtabe, Didier, Skinner, Jeff, Sturdevant, Dan, Ricklefs, Stacy, Virtaneva, Kimmo, Asghar, Muhammad, Homann, Manijeh Vafa, Turner, Louise, Martins, Joana, Allman, Erik L, N'Dri, Marie-Esther, Winkler, Volker, Llinás, Manuel, Lavazec, Catherine, Martens, Craig, Färnert, Anna, Kayentao, Kassoum, Ongoiba, Aissata, Lavstsen, Thomas, Osório, Nuno S, Otto, Thomas D, Recker, Mario, Traore, Boubacar, Crompton, Peter D, Portugal, Silvia
• Format: Journal Article Magazine Article
• Language: English
• Published: United States Nature Publishing Group 01.12.2020
• Subjects: Adolescent; Adult; Analysis; Animals; Asymptomatic; Asymptomatic infection; Asymptomatic Infections - epidemiology; Child; Child, Preschool; Control; Disease transmission; Distribution; Dry season; Endemic Diseases - prevention & control; Endothelium; Erythrocytes; Erythrocytes - parasitology; Female; Genotype; Host-Parasite Interactions - genetics; Host-parasite relationships; Humans; Immune clearance; Immune response; Immune system; Immunology; Infant; Life cycles; Life Sciences; Malaria; Malaria, Falciparum - epidemiology; Malaria, Falciparum - genetics; Malaria, Falciparum - parasitology; Male; Mali - epidemiology; Medicin och hälsovetenskap; Microbiology and Parasitology; Middle Aged; Mosquitoes; Parasites; Parasitology; Physiological aspects; Plasmodium falciparum; Plasmodium falciparum - genetics; Plasmodium falciparum - pathogenicity; Rainy season; Seasonal variations (Diseases); Seasons; Spleen; Statistics; Transcription; Vector-borne diseases; Vectors; Virulence; Water availability; Young Adult; Mali

The dry season is a major challenge for Plasmodium falciparum parasites in many malaria endemic regions, where water availability limits mosquito vectors to only part of the year. How P. falciparum bridges two transmission seasons months apart, without being cleared by the human host or compromising...