Hepatitis E Virus Genotype 3 in Wild Rats, United States

The role of rodents in the epidemiology of zoonotic hepatitis E virus (HEV) infection has been a subject of considerable debate. Seroprevalence studies suggest widespread HEV infection in commensal Rattus spp. rats, but experimental transmission has been largely unsuccessful and recovery of zoonotic...

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Published inEmerging infectious diseases Vol. 18; no. 8; pp. 1268 - 1273
Main Authors Lack, Justin B., Volk, Kylie, Van Den Bussche, Ronald A.
Format Journal Article
LanguageEnglish
Published United States U.S. National Center for Infectious Diseases 01.08.2012
Centers for Disease Control and Prevention
Subjects
Animals
Animals, Wild - virology
Disease transmission
Epidemiology
Genetic aspects
Genetic transcription
Genotype
genotype 3
Hepatitis E
Hepatitis E - epidemiology
Hepatitis E - veterinary
Hepatitis E - virology
hepatitis E virus
Hepatitis E virus - classification
Hepatitis E virus - genetics
Hepatitis E virus - isolation & purification
Infection
Liver - virology
Medical research
Medicine, Experimental
Phylogeny
rats
Rats - virology
Reverse Transcriptase Polymerase Chain Reaction
RNA
RNA, Viral - genetics
Sequence Analysis, DNA
United States - epidemiology
viral RNA
viruses
Zoonoses - virology
zoonosis
United States
California
Online AccessGet full text

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Abstract The role of rodents in the epidemiology of zoonotic hepatitis E virus (HEV) infection has been a subject of considerable debate. Seroprevalence studies suggest widespread HEV infection in commensal Rattus spp. rats, but experimental transmission has been largely unsuccessful and recovery of zoonotic genotype 3 HEV RNA from wild Rattus spp. rats has never been confirmed. We surveyed R. rattus and R. norvegicus rats from across the United States and several international populations by using a hemi-nested reverse transcription PCR approach. We isolated HEV RNA in liver tissues from 35 of 446 rats examined. All but 1 of these isolates was relegated to the zoonotic HEV genotype 3, and the remaining sequence represented the recently discovered rat genotype from the United States and Germany. HEV-positive rats were detected in urban and remote localities. Genetic analyses suggest all HEV genotype 3 isolates obtained from wild Rattus spp. rats were closely related.
AbstractList Rodents infected with this virus may be a serious threat to public health. The role of rodents in the epidemiology of zoonotic hepatitis E virus (HEV) infection has been a subject of considerable debate. Seroprevalence studies suggest widespread HEV infection in commensal Rattus spp. rats, but experimental transmission has been largely unsuccessful and recovery of zoonotic genotype 3 HEV RNA from wild Rattus spp. rats has never been confirmed. We surveyed R. rattus and R. norvegicus rats from across the United States and several international populations by using a hemi-nested reverse transcription PCR approach. We isolated HEV RNA in liver tissues from 35 of 446 rats examined. All but 1 of these isolates was relegated to the zoonotic HEV genotype 3, and the remaining sequence represented the recently discovered rat genotype from the United States and Germany. HEV-positive rats were detected in urban and remote localities. Genetic analyses suggest all HEV genotype 3 isolates obtained from wild Rattus spp. rats were closely related.
The role of rodents in the epidemiology of zoonotic hepatitis E virus (HEV) infection has been a subject of considerable debate. Seroprevalence studies suggest widespread HEV infection in commensal Rattus spp. rats, but experimental transmission has been largely unsuccessful and recovery of zoonotic genotype 3 HEV RNA from wild Rattus spp. rats has never been confirmed. We surveyed R. rattus and R. norvegicus rats from across the United States and several international populations by using a hemi-nested reverse transcription PCR approach. We isolated HEV RNA in liver tissues from 35 of 446 rats examined. All but 1 of these isolates was relegated to the zoonotic HEV genotype 3, and the remaining sequence represented the recently discovered rat genotype from the United States and Germany. HEV-positive rats were detected in urban and remote localities. Genetic analyses suggest all HEV genotype 3 isolates obtained from wild Rattus spp. rats were closely related.The role of rodents in the epidemiology of zoonotic hepatitis E virus (HEV) infection has been a subject of considerable debate. Seroprevalence studies suggest widespread HEV infection in commensal Rattus spp. rats, but experimental transmission has been largely unsuccessful and recovery of zoonotic genotype 3 HEV RNA from wild Rattus spp. rats has never been confirmed. We surveyed R. rattus and R. norvegicus rats from across the United States and several international populations by using a hemi-nested reverse transcription PCR approach. We isolated HEV RNA in liver tissues from 35 of 446 rats examined. All but 1 of these isolates was relegated to the zoonotic HEV genotype 3, and the remaining sequence represented the recently discovered rat genotype from the United States and Germany. HEV-positive rats were detected in urban and remote localities. Genetic analyses suggest all HEV genotype 3 isolates obtained from wild Rattus spp. rats were closely related.
The role of rodents in the epidemiology of zoonotic hepatitis E virus (HEV) infection has been a subject of considerable debate. Seroprevalence studies suggest widespread HEV infection in commensal Rattus spp. rats, but experimental transmission has been largely unsuccessful and recovery of zoonotic genotype 3 HEV RNA from wild Rattus spp. rats has never been confirmed. We surveyed R. rattus and R. norvegicus rats from across the United States and several international populations by using a hemi-nested reverse transcription PCR approach. We isolated HEV RNA in liver tissues from 35 of 446 rats examined. All but 1 of these isolates was relegated to the zoonotic HEV genotype 3, and the remaining sequence represented the recently discovered rat genotype from the United States and Germany. HEV-positive rats were detected in urban and remote localities. Genetic analyses suggest all HEV genotype 3 isolates obtained from wild Rattus spp. rats were closely related.
Audience Professional
Academic
Author Van Den Bussche, Ronald A.
Volk, Kylie
Lack, Justin B.
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  surname: Van Den Bussche
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Snippet The role of rodents in the epidemiology of zoonotic hepatitis E virus (HEV) infection has been a subject of considerable debate. Seroprevalence studies suggest...
Rodents infected with this virus may be a serious threat to public health. The role of rodents in the epidemiology of zoonotic hepatitis E virus (HEV)...
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SubjectTerms Animals
Animals, Wild - virology
Disease transmission
Epidemiology
Genetic aspects
Genetic transcription
Genotype
genotype 3
Hepatitis E
Hepatitis E - epidemiology
Hepatitis E - veterinary
Hepatitis E - virology
hepatitis E virus
Hepatitis E virus - classification
Hepatitis E virus - genetics
Hepatitis E virus - isolation & purification
Infection
Liver - virology
Medical research
Medicine, Experimental
Phylogeny
rats
Rats - virology
Reverse Transcriptase Polymerase Chain Reaction
RNA
RNA, Viral - genetics
Sequence Analysis, DNA
United States - epidemiology
viral RNA
viruses
Zoonoses - virology
zoonosis
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Title Hepatitis E Virus Genotype 3 in Wild Rats, United States
URI https://www.ncbi.nlm.nih.gov/pubmed/22840202
https://www.proquest.com/docview/1030349245
https://pubmed.ncbi.nlm.nih.gov/PMC3414038
https://doaj.org/article/edde998d504a4e75820da62e7983724b
Volume 18
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