Atomoxetine Attenuates Dextroamphetamine Effects in Humans

• Published in: The American journal of drug and alcohol abuse Vol. 35; no. 6; pp. 412 - 416
• Main Authors: Sofuoglu, Mehmet, Poling, James, Hill, Kevin, Kosten, Thomas
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 15.12.2009; Taylor & Francis; Taylor & Francis Ltd
• Subjects: Addiction; Adrenergic Uptake Inhibitors - pharmacology; Adult; Affect - drug effects; Amphetamines; Atomoxetine; Atomoxetine Hydrochloride; Blood Pressure; Blood Pressure - drug effects; Central Nervous System Stimulants - antagonists & inhibitors; Central Nervous System Stimulants - pharmacology; Cortisol; dextroamphetamine; Dextroamphetamine - antagonists & inhibitors; Dextroamphetamine - pharmacology; Dextroamphetamines; Drug Abuse; Drug addiction; Drug Interactions; Female; Heart Rate - drug effects; Humans; Hydrocortisone - blood; Male; Methamphetamine; norepinephrine; Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors; Propylamines - pharmacology; Selfreport; Side effects; Stimulants; Studies; Treatment Methods; Volunteers

Background: Although preclinical studies support the contribution of the noradrenergic system activation in mediating the acute effects of amphetamines, these findings have not been followed up in clinical studies. Objectives: To examine the effects of atomoxetine, a norepinephrine transporter inhib...