Distinguishing Zika and Dengue Viruses through Simple Clinical Assessment, Singapore

• Published in: Emerging infectious diseases Vol. 24; no. 8; pp. 1565 - 1568
• Main Authors: Yan, Gabriel, Pang, Long, Cook, Alex R, Ho, Hanley J, Win, Mar Soe, Khoo, Ai Leng, Wong, Joshua G X, Lee, Chun Kiat, Yan, Benedict, Jureen, Roland, Ho, Siew Seen, Lye, David C, Tambyah, Paul A, Leo, Yee Sin, Fisher, Dale, Oon, Jolene, Bagdasarian, Natasha, Chow, Angela, Smitasin, Nares, Chai, Louis Yi Ann
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.08.2018; Centers for Disease Control and Prevention
• Subjects: Adult; Aedes - virology; Aged; Animals; Case-Control Studies; Cohort Studies; Conjunctivitis; Conjunctivitis, Viral - diagnosis; Conjunctivitis, Viral - physiopathology; Conjunctivitis, Viral - virology; Dengue - diagnosis; Dengue - physiopathology; Dengue - transmission; Dengue - virology; Dengue Virus; Diagnosis, Differential; Dispatch; Distinguishing Zika and Dengue Viruses through Simple Clinical Assessment, Singapore; Female; Fever - diagnosis; Fever - physiopathology; Fever - virology; Health aspects; Health care industry; Humans; Infection; Leukocyte Count; Male; Medical research; Middle Aged; Mosquito Vectors - virology; Myalgia - diagnosis; Myalgia - physiopathology; Myalgia - virology; Platelet Count; platelets; ROC Curve; Singapore; Southeast Asia; viruses; Zika Virus; Zika Virus Infection - diagnosis; Zika Virus Infection - physiopathology; Zika Virus Infection - transmission; Zika Virus Infection - virology; Singapore; Southeast Asia; Southeast Asia; viruses; Singapore; dengue virus; zoonoses; Zika virus; conjunctivitis; platelets
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid2408.171883

Dengue virus and Zika virus coexist in tropical regions in Asia where healthcare resources are limited; differentiating the 2 viruses is challenging. We showed in a case-control discovery cohort, and replicated in a validation cohort, that the diagnostic indices of conjunctivitis, platelet count, and monocyte count reliably distinguished between these viruses.