Age-related decline in the expression of GDF9 and BMP15 genes in follicle fluid and granulosa cells derived from poor ovarian responders

• Published in: Journal of ovarian research Vol. 14; no. 1; pp. 1 - 10
• Main Authors: Gong, Yan, Li-Ling, Jesse, Xiong, Dongsheng, Wei, Jiajing, Zhong, Taiqing, Tan, Hao
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.01.2021; BioMed Central; BMC
• Subjects: Age; Blood; BMP15 gene; Bone morphogenetic proteins; E coli; Embryo transfer; Embryos; Enzyme-linked immunosorbent assay; Enzymes; Follicles; Folliculogenesis; GDF9 gene; Genes; Genetic research; Gonadotropin-releasing hormone; Granulosa cells; Growth differentiation factor 9; Growth factors; Implantation; In vitro fertilization; Infertility; Miscarriage; mRNA; Oocytes; Ovaries; Ovulation; Patients; Pharmaceuticals; Polymerase chain reaction; Poor ovarian response; Pregnancy; Proteins; RNA; Vagina; Western blotting; Beijing China; United States > US; China; Germany; In vitro fertilization; Poor ovarian response; GDF9 gene; BMP15 gene; Age

Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) genes play important roles in folliculogenesis. Altered expression of the two have been found among patients with poor ovarian response (POR). In this prospective cohort study, we have determined the expression of the G...