Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics

• Published in: The EMBO journal Vol. 29; no. 11; pp. 1889 - 1902
• Main Authors: Rust, Marco B, Gurniak, Christine B, Renner, Marianne, Vara, Hugo, Morando, Laura, Görlich, Andreas, Sassoè-Pognetto, Marco, Banchaabouchi, Mumna Al, Giustetto, Maurizio, Triller, Antoine, Choquet, Daniel, Witke, Walter
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 02.06.2010; Nature Publishing Group UK; Blackwell Publishing Ltd; Nature Publishing Group
• Subjects: actin cytoskeleton; Actin Depolymerizing Factors - metabolism; Actins - metabolism; Actins - physiology; Animals; Binding sites; Carrier Proteins - metabolism; Cell Membrane - metabolism; Cofilin 1 - metabolism; Cytoskeleton - metabolism; Dendritic Spines - metabolism; Dendritic Spines - physiology; EMBO05; EMBO27; Learning; Long-Term Potentiation - physiology; Memory; Mice; Mice, Transgenic; Microfilament Proteins - metabolism; Molecular biology; Neurology; neuronal physiology; Neuronal Plasticity - physiology; Neurons; Physiology; Proteins; Receptors, AMPA - metabolism; Spine; synaptic plasticity; actin cytoskeleton; neuronal physiology; synaptic plasticity

Neuronal plasticity is an important process for learning, memory and complex behaviour. Rapid remodelling of the actin cytoskeleton in the postsynaptic compartment is thought to have an important function for synaptic plasticity. However, the actin‐binding proteins involved and the molecular mechani...