The translation of non-canonical open reading frames controls mucosal immunity

• Published in: Nature (London) Vol. 564; no. 7736; pp. 434 - 438
• Main Authors: Jackson, Ruaidhrí, Kroehling, Lina, Khitun, Alexandra, Bailis, Will, Jarret, Abigail, York, Autumn G., Khan, Omair M., Brewer, J. Richard, Skadow, Mathias H., Duizer, Coco, Harman, Christian C. D., Chang, Lelina, Bielecki, Piotr, Solis, Angel G., Steach, Holly R., Slavoff, Sarah, Flavell, Richard A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2018; Nature Publishing Group
• Subjects: 38; 38/39; 38/91; 631/208/726; 631/250/347; 631/337/574; 64; 64/60; 82/58; Animals; Annotations; B cells; Bacterial diseases; Bacterial infections; Bacterial Infections - genetics; Bacterial Infections - immunology; Bacterial Infections - metabolism; Bacterial Infections - microbiology; Bioinformatics; Codons; Colitis; Colitis - genetics; Colitis - immunology; Colitis - metabolism; Gene expression; Genes; Genomes; Genomics; Humanities and Social Sciences; Immune response; Immune system; Immunity; Immunity, Mucosal - drug effects; Immunity, Mucosal - genetics; Infection; Infections; Inflammation; Inflammatory bowel disease; Interleukin-12 - biosynthesis; Letter; Lipopolysaccharides - pharmacology; Macrophages; Macrophages - immunology; Macrophages - metabolism; Methionine; Mice; Mucosal immunity; Mucous membrane; multidisciplinary; Non-coding RNA; Open reading frames; Open Reading Frames - genetics; Peptides; Physiological aspects; Protein Biosynthesis - drug effects; Protein Biosynthesis - genetics; Proteins; Resveratrol; Ribonucleic acid; Ribosomes; Ribosomes - drug effects; Ribosomes - metabolism; RNA; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Salmonella; Salmonella typhimurium - immunology; Science; Science (multidisciplinary); Transcriptome - drug effects; Transcriptome - genetics; Translation

The annotation of the mammalian protein-coding genome is incomplete. Arbitrary size restriction of open reading frames (ORFs) and the absolute requirement for a methionine codon as the sole initiator of translation have constrained the identification of potentially important transcripts with non-can...