A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens - Tan, Joshua; Pieper, Kathrin; Piccoli, Luca; Abdi, Abdirahman; Foglierini, Mathilde; Geiger, Roger; Maria Tully, Claire; Jarrossay, David; Maina Ndungu, Francis; Wambua, Juliana; Bejon, Philip; Silacci Fregni, Chiara; et al. (Nature (London), 2016)
Keywords: 631/250/2152/2153/1291; 631/250/255/1629; Amino Acid Sequence; Amino acids; Antibodies, Monoclonal - chemistry; Antibodies, Monoclonal - genetics; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - therapeutic use; Antibody Specificity; Antigen-antibody reactions; Antigenic Variation - immunology; Antigens; Antigens, Protozoan - immunology; B-Lymphocytes - cytology; B-Lymphocytes - immunology; Chromosomes; Clone Cells - cytology; Clone Cells - immunology; Collagen - immunology; Collagen - metabolism; Conserved Sequence - immunology; Deoxyribonucleic acid; DNA; DNA Transposable Elements - genetics; DNA Transposable Elements - immunology; Epitopes, B-Lymphocyte - chemistry; Epitopes, B-Lymphocyte - immunology; Erythrocytes; Erythrocytes - immunology; Erythrocytes - metabolism; Erythrocytes - parasitology; Genes; Genetic aspects; Genetic variation; Host-parasite relationships; Humanities and Social Sciences; Humans; Immunoglobulins; Kenya; letter; Malaria; Malaria - immunology; Malaria - parasitology; Malaria Vaccines - chemistry; Malaria Vaccines - immunology; Membrane Proteins - chemistry; Membrane Proteins - immunology; Molecular Sequence Data; Monoclonal antibodies; multidisciplinary; Mutagenesis, Insertional - genetics; Mutation; Observations; Plasmodium falciparum - immunology; Protein Structure, Tertiary - genetics; Protozoan Proteins - chemistry; Protozoan Proteins - immunology; Receptors, Immunologic - chemistry; Receptors, Immunologic - genetics; Receptors, Immunologic - immunology; Receptors, Immunologic - metabolism; Science; Vaccines; Vector-borne diseases; Kenya