SPIO-conjugated, doxorubicin-loaded microbubbles for concurrent MRI and focused-ultrasound enhanced brain-tumor drug delivery

• Published in: Biomaterials Vol. 34; no. 14; pp. 3706 - 3715
• Main Authors: Fan, Ching-Hsiang, Ting, Chien-Yu, Lin, Han-Jung, Wang, Chung-Hsin, Liu, Hao-Li, Yen, Tzu-Chen, Yeh, Chih-Kuang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.05.2013
• Subjects: acoustic properties; Advanced Basic Science; Animals; Blood-brain barrier; Brain Neoplasms - diagnosis; Brain Neoplasms - drug therapy; Cell Line, Tumor; Chemical compounds; Contrast agents; Dentistry; Deposition; doxorubicin; Doxorubicin - administration & dosage; Doxorubicin - chemistry; Doxorubicin - therapeutic use; Drug delivery systems; Drug Delivery Systems - methods; Ferric Compounds - chemistry; Focused ultrasound; Glioblastoma; image analysis; Imaging; iron oxides; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Microbubbles; nanoparticles; neoplasms; Pharmacology; Rats; Rats, Sprague-Dawley; Superparamagnetic iron oxide; Tumors; ultrasonics; Microbubbles; Focused ultrasound; Blood-brain barrier; Superparamagnetic iron oxide; Glioblastoma

The blood–brain barrier (BBB) can be temporarily and locally opened by focused ultrasound (FUS) in the presence of circulating microbubbles (MBs). Currently, contrast-enhanced magnetic resonance imaging (CE-MRI) is used to monitor contrast agent leakage to verify BBB-opening and infer drug depositio...