SPIO-conjugated, doxorubicin-loaded microbubbles for concurrent MRI and focused-ultrasound enhanced brain-tumor drug delivery - Fan, Ching-Hsiang; Ting, Chien-Yu; Lin, Han-Jung; Wang, Chung-Hsin; Liu, Hao-Li; Yen, Tzu-Chen; Yeh, Chih-Kuang (Biomaterials, 2013)
Keywords: acoustic properties; Advanced Basic Science; Animals; Blood-brain barrier; Brain Neoplasms - diagnosis; Brain Neoplasms - drug therapy; Cell Line, Tumor; Chemical compounds; Contrast agents; Dentistry; Deposition; doxorubicin; Doxorubicin - administration & dosage; Doxorubicin - chemistry; Doxorubicin - therapeutic use; Drug delivery systems; Drug Delivery Systems - methods; Ferric Compounds - chemistry; Focused ultrasound; Glioblastoma; image analysis; Imaging; iron oxides; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Microbubbles; nanoparticles; neoplasms; Pharmacology; Rats; Rats, Sprague-Dawley; Superparamagnetic iron oxide; Tumors; ultrasonics; Microbubbles; Focused ultrasound; Blood-brain barrier; Superparamagnetic iron oxide; Glioblastoma