Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a Mediterranean allergic population

• Published in: Journal of allergy and clinical immunology Vol. 124; no. 4; pp. 771 - 778.e5
• Main Authors: Krause, Susanne, Reese, Gerald, Randow, Stefanie, Zennaro, Danila, Quaratino, Donato, Palazzo, Paola, Ciardiello, Maria Antonietta, Petersen, Arnd, Becker, Wolf-Meinhard, Mari, Adriano
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.10.2009; Elsevier; Elsevier Limited
• Subjects: 2S Albumins, Plant - immunology; 2S Albumins, Plant - metabolism; Adolescent; Adult; Aged; allergen; Allergens - immunology; Allergens - metabolism; Allergic diseases; Allergies; Allergy and Immunology; Antigens, Plant - immunology; Antigens, Plant - metabolism; Ara h 9; Arachis - immunology; Arachis hypogaea; Biological and medical sciences; Carrier Proteins - immunology; Carrier Proteins - isolation & purification; Carrier Proteins - metabolism; Chemical bonds; Child; Cross Reactions - immunology; Digestive allergic diseases; Female; Food; Food allergies; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Glycoproteins - immunology; Glycoproteins - metabolism; Humans; Immunoglobulin E - blood; Immunopathology; isoform; lipid transfer protein; Male; Medical sciences; Middle Aged; peanut allergy; Peanut Hypersensitivity - immunology; Peanut Hypersensitivity - metabolism; Peanuts; Plant Proteins - immunology; Plant Proteins - metabolism; Protein Isoforms - immunology; Protein Isoforms - metabolism; Proteins; Prunus; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Seed Storage Proteins - immunology; Seed Storage Proteins - metabolism; Young Adult; peanut allergy; allergen; IUIS; Ara h 9; rAra h 9; SPHIAa; nAra h 9; LTP; lipid transfer protein; isoform; ISAC; Recombinant Ara h 9; Immuno solid-phase allergen chip; International Union of Immunological Societies; Single point highest inhibition achievable assay; Natural Ara h 9; Human; Food allergy; Peanut; Immunopathology; Molecular form; Immunology; Lipid transfer protein; Digestive diseases; Groundnut; Allergen

Nonspecific lipid transfer proteins (LTPs) represent potent pollen and food allergens. However, the allergenic properties of peanut LTP have not been studied. To identify LTP in peanut extract using sera from subjects with peanut allergy and Pru p 3–sensitized subjects from Southern Europe, clone an...