Breast cancer cells induce osteolytic bone lesions in vivo through a reduction in osteoblast activity in mice

• Published in: PloS one Vol. 8; no. 9; p. e68103
• Main Authors: Gregory, Laura S, Choi, Wilson, Burke, Leslie, Clements, Judith A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.09.2013; Public Library of Science (PLoS)
• Subjects: Animals; Apoptosis; Apposition; Biocompatibility; Biomedical materials; Bone (trabecular); Bone cancer; Bone density; Bone growth; Bone lesions; Bone loss; Bone matrix; Bone Neoplasms - pathology; Bone Neoplasms - secondary; Bone resorption; Bones; Breast cancer; Breast Neoplasms - complications; Breast Neoplasms - pathology; Cancellous bone; Cancer; Cancer cells; Cancer metastasis; Cancer therapies; Cancer treatment; Cell Line, Tumor; Dkk1 protein; Female; Gene expression; Homology; Humans; Injection; Lesions; Metastases; Metastasis; Mice; Mice, SCID; Mycoplasma; Noggin protein; Osteoblasts; Osteoblasts - pathology; Osteogenesis; Osteolysis; Pathogenesis; Perforation; Prostate; Quality of life; Reduction; Struts; Studies; Tibia; Womens health; Queensland Australia; Australia

Bone metastases are severely debilitating and have a significant impact on the quality of life of women with metastatic breast cancer. Treatment options are limited and in order to develop more targeted therapies, improved understanding of the complex mechanisms that lead to bone lesion development...