Green tea polyphenol epigallocatechin-3-gallate (EGCG) as adjuvant in cancer therapy

• Published in: Clinical nutrition (Edinburgh, Scotland) Vol. 32; no. 6; pp. 894 - 903
• Main Authors: Lecumberri, Elena, Dupertuis, Yves Marc, Miralbell, Raymond, Pichard, Claude
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.12.2013; Elsevier
• Subjects: Adjuvant; adverse effects; analogs & derivatives; Animals; antineoplastic agents; Antineoplastic Agents - pharmacology; antioxidant activity; Apoptosis; Apoptosis - drug effects; Biological and medical sciences; Cancer therapy; Catechin; Catechin - analogs & derivatives; Catechin - pharmacology; Cell Cycle; Cell Cycle - drug effects; chemistry; chemotherapy; Chemotherapy, Adjuvant; drug effects; drug therapy; Epigallocatechin-3-gallate; Feeding. Feeding behavior; flavanols; Fundamental and applied biological sciences. Psychology; Gastroenterology and Hepatology; Green tea; Humans; Medical sciences; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Neoplasms; Neoplasms - drug therapy; Neovascularization, Pathologic; Neovascularization, Pathologic - drug therapy; pharmacology; Polyphenols; Polyphenols - pharmacology; radiotherapy; Side effects; synergism; Tea; Tea - chemistry; Tumors; Vertebrates: anatomy and physiology, studies on body, several organs or systems; IL; TSA; HBMEC; EGCG; Epigallocatechin-3-gallate; DNROL; DNR; IR; DOX; CP; Side effects; Cancer therapy; ROS; Adjuvant; ATO; HRPC; Green tea; HNE; 5-FU; arsenic trioxide; trichostatin A; hormone refractory prostate cancer; daunorubicinol; reactive oxygen species; doxorubicin; human brain microvascular endothelial cells; cisplatin; interleukin; hydroxynonenal; daunorubicin; 5-fluorouracil; ionizing radiation; Polyphenol; Adjuvant treatment; Phenols; Metabolic diseases; Malignant tumor; Cancer

Green tea catechins, especially epigallocatechin-3-gallate (EGCG), have been associated with cancer prevention and treatment. This has resulted in an increased number of studies evaluating the effects derived from the use of this compound in combination with chemo/radiotherapy. This review aims at c...