Estrogen induction of telomerase activity through regulation of the mitogen-activated protein kinase (MAPK) dependent pathway in human endometrial cancer cells

• Published in: PloS one Vol. 8; no. 2; p. e55730
• Main Authors: Zhou, Chunxiao, Steplowski, Tara A, Dickens, Hallum K, Malloy, Kimberly M, Gehrig, Paola A, Boggess, John F, Bae-Jump, Victoria L
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.02.2013; Public Library of Science (PLoS)
• Subjects: 17β-Estradiol; Biology; Butadienes - pharmacology; Cancer; Cancer cells; Carcinogenesis; Carcinogens; Cell Line, Tumor; Cloning; Deoxyribonucleic acid; DNA; Endometrial cancer; Endometrial Neoplasms - genetics; Endometrial Neoplasms - metabolism; Endometrium; Enzyme Activation - drug effects; Estradiol; Estradiol - pharmacology; Estrogen receptors; Estrogens; Estrogens - pharmacology; Exposure; Extracellular signal-regulated kinase; Female; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Gynecology; Hormones; Humans; Infection; Kinases; Luciferase; MAP kinase; Medicine; Menstruation; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - metabolism; Mitogen-Activated Protein Kinases - metabolism; Mitogens; Nitriles - pharmacology; Obstetrics; Oncology; Phenols (Class of compounds); Phosphorylation; Promoter Regions, Genetic; Protein kinase; Protein kinases; Proteins; Regulatory sequences; RNA; RNA Interference; RNA, Messenger - genetics; RNA, Messenger - metabolism; Sex hormones; Signal Transduction - drug effects; siRNA; Telomerase; Telomerase - genetics; Telomerase - metabolism; Telomerase reverse transcriptase; Transcription factors; Transfection; Uterine cancer; North Carolina; United States > US

Given that prolonged exposure to estrogen and increased telomerase activity are associated with endometrial carcinogenesis, our objective was to evaluate the interaction between the MAPK pathway and estrogen induction of telomerase activity in endometrial cancer cells. Estradiol (E2) induced telomer...