MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis

• Published in: Cell reports (Cambridge) Vol. 17; no. 2; pp. 469 - 483
• Main Authors: Vasconcelos, Francisca F., Sessa, Alessandro, Laranjeira, Cátia, Raposo, Alexandre A.S.F., Teixeira, Vera, Hagey, Daniel W., Tomaz, Diogo M., Muhr, Jonas, Broccoli, Vania, Castro, Diogo S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.10.2016; Cell Press; Elsevier
• Subjects: Animals; Ascl1; Basic Helix-Loop-Helix Transcription Factors - genetics; Cell Differentiation - genetics; DNA-Binding Proteins - genetics; Gene Expression Regulation, Developmental; Hes1; Inhibitor of Differentiation Proteins - genetics; Mice; MyT1; Neural Stem Cells - cytology; Neural Stem Cells - metabolism; neurogenesis; Neurogenesis - genetics; Neurons - metabolism; Notch signaling; Rbpj; Receptor, Notch1 - genetics; SOXB1 Transcription Factors - genetics; Stem Cells - cytology; Stem Cells - metabolism; transcription; Transcription Factor HES-1 - genetics; Transcription Factors - genetics; Vertebrates - genetics; Vertebrates - growth & development; transcription; Notch signaling; neurogenesis; Hes1; Rbpj; MyT1; Ascl1

The generation of neurons from neural stem cells requires large-scale changes in gene expression that are controlled to a large extent by proneural transcription factors, such as Ascl1. While recent studies have characterized the differentiation genes activated by proneural factors, less is known on...