The Functional DRD3 Ser9Gly Polymorphism (rs6280) Is Pleiotropic, Affecting Reward as Well as Movement

• Published in: PloS one Vol. 8; no. 1; p. e54108
• Main Authors: Savitz, Jonathan, Hodgkinson, Colin A., Martin-Soelch, Chantal, Shen, Pei-Hong, Szczepanik, Joanna, Nugent, Allison, Herscovitch, Peter, Grace, Anthony A., Goldman, David, Drevets, Wayne C.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.01.2013; Public Library of Science (PLoS)
• Subjects: Abnormalities; Addictions; Adult; Age Factors; Alcoholism; Alleles; Anhedonia; Anxiety; Basal Ganglia - diagnostic imaging; Basal Ganglia - metabolism; Basal Ganglia - physiopathology; Biology; Brain research; Case-Control Studies; Caudate Nucleus - diagnostic imaging; Caudate Nucleus - metabolism; Caudate Nucleus - physiopathology; Cell receptors; Cocaine; Depressive Disorder, Major - genetics; Depressive Disorder, Major - metabolism; Depressive Disorder, Major - physiopathology; Depressive Disorder, Major - psychology; Dopamine; Dopamine D2 Receptor Antagonists; Dopamine D2 receptors; Dopamine D3 receptors; Dopaminergic mechanisms; Female; Gambling; Gambling - psychology; Gene mutation; Genetic aspects; Genetics; Glycine; Health aspects; Hedonic response; Humans; Intracellular signalling; Laboratories; Male; Medical imaging; Medicine; Mental depression; Mental disorders; Middle Aged; Missense mutation; Mood; Motivation; Mutation; Neostriatum; Neurosciences; Polymorphism; Polymorphism, Genetic; Positron emission; Positron emission tomography; Psychiatry; Psychological aspects; Psychosis; Raclopride; Raclopride - pharmacology; Receptors, Dopamine D2 - metabolism; Receptors, Dopamine D3 - antagonists & inhibitors; Receptors, Dopamine D3 - metabolism; Regression analysis; Reinforcement; Reward; Rewards (Psychology); Schizophrenia; Sensorimotor system; Sex Factors; Social and Behavioral Sciences; Studies; Tomography; United States > US; Maryland; Oklahoma

Abnormalities of motivation and behavior in the context of reward are a fundamental component of addiction and mood disorders. Here we test the effect of a functional missense mutation in the dopamine 3 receptor (DRD3) gene (ser9gly, rs6280) on reward-associated dopamine (DA) release in the striatum...