Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study

• Published in: The Lancet (British edition) Vol. 383; no. 9918; pp. 714 - 721
• Main Authors: Chen, HaiYing, Yuan, Hui, Gao, Rongbao, Zhang, Jinxiang, Wang, Dayan, Xiong, Ying, Fan, GuoYin, Yang, Fan, Li, Xiaodan, Zhou, Jianfang, Zou, Shumei, Yang, Lei, Chen, Tao, Dong, Libo, Bo, Hong, Zhao, Xiang, Zhang, Ye, Lan, Yu, Bai, Tian, Dong, Jie, Li, Qun, Wang, ShiWen, Zhang, YanPing, Li, Hui, Gong, Tian, Shi, Yong, Ni, Xiansheng, Li, Jianxiong, Zhou, Jun, Fan, Jiyi, Wu, Jingwen, Zhou, Xianfeng, Hu, Maohong, Wan, Jianguo, Yang, WeiZhong, Li, DeXin, Wu, Guizhen, Feng, ZiJian, Gao, George F, Wang, Yu, Jin, Qi, Liu, Mingbin, Shu, Yuelong
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 22.02.2014; Elsevier; Elsevier Limited
• Subjects: Aged; Animals; Antiviral Agents - pharmacology; Avian flu; Bacterial infections; Binding sites; Biological and medical sciences; Blood; Cardiovascular disease; China; Commerce; Data collection; DNA, Viral - analysis; Drug resistance; Epidemiology; Exo-a-sialidase; Fatal Outcome; Fatalities; Female; General aspects; Genes; Genomes; Glutamate receptors; Glutamic acid; Glutamic Acid - metabolism; Hemagglutinins; Hospitals; Humans; Illnesses; Infections; Infectious diseases; Influenza; Influenza A; Influenza A virus - classification; Influenza A virus - drug effects; Influenza A virus - genetics; Influenza A Virus, H9N2 Subtype - isolation & purification; Influenza in Birds - virology; Influenza virus; Influenza, Human - diagnosis; Influenza, Human - drug therapy; Influenza, Human - virology; Internal Medicine; Leukocytes; Lysine; Lysine - metabolism; Medical laboratories; Medical sciences; Miscellaneous; Mortality; Multiple Organ Failure - virology; Mutation; Neuraminidase - antagonists & inhibitors; Pandemics; Patients; Phylogeny; Pneumonia; Poultry - virology; Proteins; Public health; Public health. Hygiene; Public health. Hygiene-occupational medicine; Research projects; Residues; Reverse Transcriptase Polymerase Chain Reaction; Review boards; RNA Replicase - metabolism; Sequence analysis; Sequence Analysis, DNA; Sputum; Surveillance; Trachea - virology; Viral Proteins - metabolism; Viruses; China; United States > US; Germany; China, People's Rep; Orthomyxoviridae; Epidemiology; Fatal course; Infection; Virus; Avian influenza; Medicine; Symptomatology; Influenzavirus A; Influenza A virus; Viral disease; Influenza A; Public health

Human infections with different avian influenza viruses—eg, H5N1, H9N2, and H7N9—have raised concerns about pandemic potential worldwide. We report the first human infection with a novel reassortant avian influenza A H10N8 virus. We obtained and analysed clinical, epidemiological, and virological da...