Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study

Human infections with different avian influenza viruses—eg, H5N1, H9N2, and H7N9—have raised concerns about pandemic potential worldwide. We report the first human infection with a novel reassortant avian influenza A H10N8 virus. We obtained and analysed clinical, epidemiological, and virological da...

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Published inThe Lancet (British edition) Vol. 383; no. 9918; pp. 714 - 721
Main Authors Chen, HaiYing, Yuan, Hui, Gao, Rongbao, Zhang, Jinxiang, Wang, Dayan, Xiong, Ying, Fan, GuoYin, Yang, Fan, Li, Xiaodan, Zhou, Jianfang, Zou, Shumei, Yang, Lei, Chen, Tao, Dong, Libo, Bo, Hong, Zhao, Xiang, Zhang, Ye, Lan, Yu, Bai, Tian, Dong, Jie, Li, Qun, Wang, ShiWen, Zhang, YanPing, Li, Hui, Gong, Tian, Shi, Yong, Ni, Xiansheng, Li, Jianxiong, Zhou, Jun, Fan, Jiyi, Wu, Jingwen, Zhou, Xianfeng, Hu, Maohong, Wan, Jianguo, Yang, WeiZhong, Li, DeXin, Wu, Guizhen, Feng, ZiJian, Gao, George F, Wang, Yu, Jin, Qi, Liu, Mingbin, Shu, Yuelong
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Ltd 22.02.2014
Elsevier
Elsevier Limited
Subjects
Aged
Animals
Antiviral Agents - pharmacology
Avian flu
Bacterial infections
Binding sites
Biological and medical sciences
Blood
Cardiovascular disease
China
Commerce
Data collection
DNA, Viral - analysis
Drug resistance
Epidemiology
Exo-a-sialidase
Fatal Outcome
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Female
General aspects
Genes
Genomes
Glutamate receptors
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Glutamic Acid - metabolism
Hemagglutinins
Hospitals
Humans
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Infections
Infectious diseases
Influenza
Influenza A
Influenza A virus - classification
Influenza A virus - drug effects
Influenza A virus - genetics
Influenza A Virus, H9N2 Subtype - isolation & purification
Influenza in Birds - virology
Influenza virus
Influenza, Human - diagnosis
Influenza, Human - drug therapy
Influenza, Human - virology
Internal Medicine
Leukocytes
Lysine
Lysine - metabolism
Medical laboratories
Medical sciences
Miscellaneous
Mortality
Multiple Organ Failure - virology
Mutation
Neuraminidase - antagonists & inhibitors
Pandemics
Patients
Phylogeny
Pneumonia
Poultry - virology
Proteins
Public health
Public health. Hygiene
Public health. Hygiene-occupational medicine
Research projects
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Reverse Transcriptase Polymerase Chain Reaction
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RNA Replicase - metabolism
Sequence analysis
Sequence Analysis, DNA
Sputum
Surveillance
Trachea - virology
Viral Proteins - metabolism
Viruses
China
United States > US
Germany
China, People's Rep
Orthomyxoviridae
Epidemiology
Fatal course
Infection
Virus
Avian influenza
Medicine
Symptomatology
Influenzavirus A
Influenza A virus
Viral disease
Influenza A
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Abstract Human infections with different avian influenza viruses—eg, H5N1, H9N2, and H7N9—have raised concerns about pandemic potential worldwide. We report the first human infection with a novel reassortant avian influenza A H10N8 virus. We obtained and analysed clinical, epidemiological, and virological data from a patient from Nanchang City, China. Tracheal aspirate specimens were tested for influenza virus and other possible pathogens by RT-PCR, viral culture, and sequence analyses. A maximum likelihood phylogenetic tree was constructed. A woman aged 73 years presented with fever and was admitted to hospital on Nov 30, 2013. She developed multiple organ failure and died 9 days after illness onset. A novel reassortant avian influenza A H10N8 virus was isolated from the tracheal aspirate specimen obtained from the patient 7 days after onset of illness. Sequence analyses revealed that all the genes of the virus were of avian origin, with six internal genes from avian influenza A H9N2 viruses. The aminoacid motif GlnSerGly at residues 226–228 of the haemagglutinin protein indicated avian-like receptor binding preference. A mixture of glutamic acid and lysine at residue 627 in PB2 protein—which is associated with mammalian adaptation—was detected in the original tracheal aspirate samples. The virus was sensitive to neuraminidase inhibitors. Sputum and blood cultures and deep sequencing analysis indicated no co-infection with bacteria or fungi. Epidemiological investigation established that the patient had visited a live poultry market 4 days before illness onset. The novel reassortant H10N8 virus obtained is distinct from previously reported H10N8 viruses. The virus caused human infection and could have been associated with the death of a patient. Emergency Research Project on human infection with avian influenza H7N9 virus, the National Basic Research Program of China, and the National Mega-projects for Infectious Diseases.
AbstractList Human infections with different avian influenza viruses--eg, H5N1, H9N2, and H7N9--have raised concerns about pandemic potential worldwide. We report the first human infection with a novel reassortant avian influenza A H10N8 virus.BACKGROUNDHuman infections with different avian influenza viruses--eg, H5N1, H9N2, and H7N9--have raised concerns about pandemic potential worldwide. We report the first human infection with a novel reassortant avian influenza A H10N8 virus.We obtained and analysed clinical, epidemiological, and virological data from a patient from Nanchang City, China. Tracheal aspirate specimens were tested for influenza virus and other possible pathogens by RT-PCR, viral culture, and sequence analyses. A maximum likelihood phylogenetic tree was constructed.METHODSWe obtained and analysed clinical, epidemiological, and virological data from a patient from Nanchang City, China. Tracheal aspirate specimens were tested for influenza virus and other possible pathogens by RT-PCR, viral culture, and sequence analyses. A maximum likelihood phylogenetic tree was constructed.A woman aged 73 years presented with fever and was admitted to hospital on Nov 30, 2013. She developed multiple organ failure and died 9 days after illness onset. A novel reassortant avian influenza A H10N8 virus was isolated from the tracheal aspirate specimen obtained from the patient 7 days after onset of illness. Sequence analyses revealed that all the genes of the virus were of avian origin, with six internal genes from avian influenza A H9N2 viruses. The aminoacid motif GlnSerGly at residues 226-228 of the haemagglutinin protein indicated avian-like receptor binding preference. A mixture of glutamic acid and lysine at residue 627 in PB2 protein--which is associated with mammalian adaptation--was detected in the original tracheal aspirate samples. The virus was sensitive to neuraminidase inhibitors. Sputum and blood cultures and deep sequencing analysis indicated no co-infection with bacteria or fungi. Epidemiological investigation established that the patient had visited a live poultry market 4 days before illness onset.FINDINGSA woman aged 73 years presented with fever and was admitted to hospital on Nov 30, 2013. She developed multiple organ failure and died 9 days after illness onset. A novel reassortant avian influenza A H10N8 virus was isolated from the tracheal aspirate specimen obtained from the patient 7 days after onset of illness. Sequence analyses revealed that all the genes of the virus were of avian origin, with six internal genes from avian influenza A H9N2 viruses. The aminoacid motif GlnSerGly at residues 226-228 of the haemagglutinin protein indicated avian-like receptor binding preference. A mixture of glutamic acid and lysine at residue 627 in PB2 protein--which is associated with mammalian adaptation--was detected in the original tracheal aspirate samples. The virus was sensitive to neuraminidase inhibitors. Sputum and blood cultures and deep sequencing analysis indicated no co-infection with bacteria or fungi. Epidemiological investigation established that the patient had visited a live poultry market 4 days before illness onset.The novel reassortant H10N8 virus obtained is distinct from previously reported H10N8 viruses. The virus caused human infection and could have been associated with the death of a patient.INTERPRETATIONThe novel reassortant H10N8 virus obtained is distinct from previously reported H10N8 viruses. The virus caused human infection and could have been associated with the death of a patient.Emergency Research Project on human infection with avian influenza H7N9 virus, the National Basic Research Program of China, and the National Mega-projects for Infectious Diseases.FUNDINGEmergency Research Project on human infection with avian influenza H7N9 virus, the National Basic Research Program of China, and the National Mega-projects for Infectious Diseases.
Human infections with different avian influenza viruses--eg, H5N1, H9N2, and H7N9--have raised concerns about pandemic potential worldwide. We report the first human infection with a novel reassortant avian influenza A H10N8 virus. We obtained and analysed clinical, epidemiological, and virological data from a patient from Nanchang City, China. Tracheal aspirate specimens were tested for influenza virus and other possible pathogens by RT-PCR, viral culture, and sequence analyses. A maximum likelihood phylogenetic tree was constructed. A woman aged 73 years presented with fever and was admitted to hospital on Nov 30, 2013. She developed multiple organ failure and died 9 days after illness onset. A novel reassortant avian influenza A H10N8 virus was isolated from the tracheal aspirate specimen obtained from the patient 7 days after onset of illness. Sequence analyses revealed that all the genes of the virus were of avian origin, with six internal genes from avian influenza A H9N2 viruses. The aminoacid motif GlnSerGly at residues 226-228 of the haemagglutinin protein indicated avian-like receptor binding preference. A mixture of glutamic acid and lysine at residue 627 in PB2 protein--which is associated with mammalian adaptation--was detected in the original tracheal aspirate samples. The virus was sensitive to neuraminidase inhibitors. Sputum and blood cultures and deep sequencing analysis indicated no co-infection with bacteria or fungi. Epidemiological investigation established that the patient had visited a live poultry market 4 days before illness onset. The novel reassortant H10N8 virus obtained is distinct from previously reported H10N8 viruses. The virus caused human infection and could have been associated with the death of a patient. Emergency Research Project on human infection with avian influenza H7N9 virus, the National Basic Research Program of China, and the National Mega-projects for Infectious Diseases.
Human infections with different avian influenza viruses--eg, H5N1, H9N2, and H7N9--have raised concerns about pandemic potential worldwide. We report the first human infection with a novel reassortant avian influenza A H10N8 virus. Methods We obtained and analysed clinical, epidemiological, and virological data from a patient from Nanchang City, China. Tracheal aspirate specimens were tested for influenza virus and other possible pathogens by RT-PCR, viral culture, and sequence analyses. A maximum likelihood phylogenetic tree was constructed. Findings A woman aged 73 years presented with fever and was admitted to hospital on Nov 30, 2013. She developed multiple organ failure and died 9 days after illness onset. A novel reassortant avian influenza A H10N8 virus was isolated from the tracheal aspirate specimen obtained from the patient 7 days after onset of illness. Sequence analyses revealed that all the genes of the virus were of avian origin, with six internal genes from avian influenza A H9N2 viruses. The aminoacid motif GlnSerGly at residues 226-228 of the haemagglutinin protein indicated avian-like receptor binding preference. A mixture of glutamic acid and lysine at residue 627 in PB2 protein--which is associated with mammalian adaptation--was detected in the original tracheal aspirate samples. The virus was sensitive to neuraminidase inhibitors. Sputum and blood cultures and deep sequencing analysis indicated no co-infection with bacteria or fungi. Epidemiological investigation established that the patient had visited a live poultry market 4 days before illness onset. Interpretation The novel reassortant H10N8 virus obtained is distinct from previously reported H10N8 viruses. The virus caused human infection and could have been associated with the death of a patient. Funding Emergency Research Project on human infection with avian influenza H7N9 virus, the National Basic Research Program of China, and the National Mega-projects for Infectious Diseases.
Summary Background Human infections with different avian influenza viruses—eg, H5N1, H9N2, and H7N9—have raised concerns about pandemic potential worldwide. We report the first human infection with a novel reassortant avian influenza A H10N8 virus. Methods We obtained and analysed clinical, epidemiological, and virological data from a patient from Nanchang City, China. Tracheal aspirate specimens were tested for influenza virus and other possible pathogens by RT-PCR, viral culture, and sequence analyses. A maximum likelihood phylogenetic tree was constructed. Findings A woman aged 73 years presented with fever and was admitted to hospital on Nov 30, 2013. She developed multiple organ failure and died 9 days after illness onset. A novel reassortant avian influenza A H10N8 virus was isolated from the tracheal aspirate specimen obtained from the patient 7 days after onset of illness. Sequence analyses revealed that all the genes of the virus were of avian origin, with six internal genes from avian influenza A H9N2 viruses. The aminoacid motif GlnSerGly at residues 226–228 of the haemagglutinin protein indicated avian-like receptor binding preference. A mixture of glutamic acid and lysine at residue 627 in PB2 protein—which is associated with mammalian adaptation—was detected in the original tracheal aspirate samples. The virus was sensitive to neuraminidase inhibitors. Sputum and blood cultures and deep sequencing analysis indicated no co-infection with bacteria or fungi. Epidemiological investigation established that the patient had visited a live poultry market 4 days before illness onset. Interpretation The novel reassortant H10N8 virus obtained is distinct from previously reported H10N8 viruses. The virus caused human infection and could have been associated with the death of a patient. Funding Emergency Research Project on human infection with avian influenza H7N9 virus, the National Basic Research Program of China, and the National Mega-projects for Infectious Diseases.
Background Human infections with different avian influenza viruses-eg, H5N1, H9N2, and H7N9-have raised concerns about pandemic potential worldwide. We report the first human infection with a novel reassortant avian influenza A H10N8 virus. Methods We obtained and analysed clinical, epidemiological, and virological data from a patient from Nanchang City, China. Tracheal aspirate specimens were tested for influenza virus and other possible pathogens by RT-PCR, viral culture, and sequence analyses. A maximum likelihood phylogenetic tree was constructed. Findings A woman aged 73 years presented with fever and was admitted to hospital on Nov 30, 2013. She developed multiple organ failure and died 9 days after illness onset. A novel reassortant avian influenza A H10N8 virus was isolated from the tracheal aspirate specimen obtained from the patient 7 days after onset of illness. Sequence analyses revealed that all the genes of the virus were of avian origin, with six internal genes from avian influenza A H9N2 viruses. The aminoacid motif GlnSerGly at residues 226-228 of the haemagglutinin protein indicated avian-like receptor binding preference. A mixture of glutamic acid and lysine at residue 627 in PB2 protein-which is associated with mammalian adaptation-was detected in the original tracheal aspirate samples. The virus was sensitive to neuraminidase inhibitors. Sputum and blood cultures and deep sequencing analysis indicated no co-infection with bacteria or fungi. Epidemiological investigation established that the patient had visited a live poultry market 4 days before illness onset. Interpretation The novel reassortant H10N8 virus obtained is distinct from previously reported H10N8 viruses. The virus caused human infection and could have been associated with the death of a patient. Funding Emergency Research Project on human infection with avian influenza H7N9 virus, the National Basic Research Program of China, and the National Mega-projects for Infectious Diseases.
Author Bai, Tian
Zhou, Jun
Jin, Qi
Li, Xiaodan
Chen, Tao
Li, DeXin
Dong, Libo
Wang, Dayan
Zhang, Jinxiang
Zhang, Ye
Chen, HaiYing
Zhang, YanPing
Zhou, Xianfeng
Xiong, Ying
Bo, Hong
Gong, Tian
Zhou, Jianfang
Yang, WeiZhong
Ni, Xiansheng
Hu, Maohong
Wang, Yu
Gao, Rongbao
Wang, ShiWen
Fan, Jiyi
Fan, GuoYin
Gao, George F
Liu, Mingbin
Li, Hui
Lan, Yu
Shi, Yong
Dong, Jie
Yang, Lei
Wu, Guizhen
Yang, Fan
Zou, Shumei
Feng, ZiJian
Zhao, Xiang
Li, Qun
Li, Jianxiong
Wu, Jingwen
Yuan, Hui
Wan, Jianguo
Shu, Yuelong
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  givenname: HaiYing
  surname: Chen
  fullname: Chen, HaiYing
  organization: Nanchang City Disease Control and Prevention, Nanchang, China
– sequence: 2
  givenname: Hui
  surname: Yuan
  fullname: Yuan, Hui
  organization: Jiangxi Provincial Disease Control and Prevention, Nanchang, China
– sequence: 3
  givenname: Rongbao
  surname: Gao
  fullname: Gao, Rongbao
  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China
– sequence: 4
  givenname: Jinxiang
  surname: Zhang
  fullname: Zhang, Jinxiang
  organization: The First Hospital of Nanchang, Nanchang, China
– sequence: 5
  givenname: Dayan
  surname: Wang
  fullname: Wang, Dayan
  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China
– sequence: 6
  givenname: Ying
  surname: Xiong
  fullname: Xiong, Ying
  organization: Jiangxi Provincial Disease Control and Prevention, Nanchang, China
– sequence: 7
  givenname: GuoYin
  surname: Fan
  fullname: Fan, GuoYin
  organization: Nanchang City Disease Control and Prevention, Nanchang, China
– sequence: 8
  givenname: Fan
  surname: Yang
  fullname: Yang, Fan
  organization: MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
– sequence: 9
  givenname: Xiaodan
  surname: Li
  fullname: Li, Xiaodan
  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China
– sequence: 10
  givenname: Jianfang
  surname: Zhou
  fullname: Zhou, Jianfang
  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China
– sequence: 11
  givenname: Shumei
  surname: Zou
  fullname: Zou, Shumei
  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China
– sequence: 12
  givenname: Lei
  surname: Yang
  fullname: Yang, Lei
  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China
– sequence: 13
  givenname: Tao
  surname: Chen
  fullname: Chen, Tao
  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China
– sequence: 14
  givenname: Libo
  surname: Dong
  fullname: Dong, Libo
  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China
– sequence: 15
  givenname: Hong
  surname: Bo
  fullname: Bo, Hong
  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China
– sequence: 16
  givenname: Xiang
  surname: Zhao
  fullname: Zhao, Xiang
  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China
– sequence: 17
  givenname: Ye
  surname: Zhang
  fullname: Zhang, Ye
  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China
– sequence: 18
  givenname: Yu
  surname: Lan
  fullname: Lan, Yu
  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China
– sequence: 19
  givenname: Tian
  surname: Bai
  fullname: Bai, Tian
  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China
– sequence: 20
  givenname: Jie
  surname: Dong
  fullname: Dong, Jie
  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China
– sequence: 21
  givenname: Qun
  surname: Li
  fullname: Li, Qun
  organization: Chinese Center for Disease Control and Prevention, Beijing, China
– sequence: 22
  givenname: ShiWen
  surname: Wang
  fullname: Wang, ShiWen
  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China
– sequence: 23
  givenname: YanPing
  surname: Zhang
  fullname: Zhang, YanPing
  organization: Chinese Center for Disease Control and Prevention, Beijing, China
– sequence: 24
  givenname: Hui
  surname: Li
  fullname: Li, Hui
  organization: Nanchang City Disease Control and Prevention, Nanchang, China
– sequence: 25
  givenname: Tian
  surname: Gong
  fullname: Gong, Tian
  organization: Jiangxi Provincial Disease Control and Prevention, Nanchang, China
– sequence: 26
  givenname: Yong
  surname: Shi
  fullname: Shi, Yong
  organization: Jiangxi Provincial Disease Control and Prevention, Nanchang, China
– sequence: 27
  givenname: Xiansheng
  surname: Ni
  fullname: Ni, Xiansheng
  organization: Nanchang City Disease Control and Prevention, Nanchang, China
– sequence: 28
  givenname: Jianxiong
  surname: Li
  fullname: Li, Jianxiong
  organization: Jiangxi Provincial Disease Control and Prevention, Nanchang, China
– sequence: 29
  givenname: Jun
  surname: Zhou
  fullname: Zhou, Jun
  organization: Jiangxi Provincial Disease Control and Prevention, Nanchang, China
– sequence: 30
  givenname: Jiyi
  surname: Fan
  fullname: Fan, Jiyi
  organization: Donghu District Center for Disease Control and Prevention, Nanchang, China
– sequence: 31
  givenname: Jingwen
  surname: Wu
  fullname: Wu, Jingwen
  organization: Nanchang City Disease Control and Prevention, Nanchang, China
– sequence: 32
  givenname: Xianfeng
  surname: Zhou
  fullname: Zhou, Xianfeng
  organization: Nanchang City Disease Control and Prevention, Nanchang, China
– sequence: 33
  givenname: Maohong
  surname: Hu
  fullname: Hu, Maohong
  organization: Nanchang City Disease Control and Prevention, Nanchang, China
– sequence: 34
  givenname: Jianguo
  surname: Wan
  fullname: Wan, Jianguo
  organization: The First Hospital of Nanchang, Nanchang, China
– sequence: 35
  givenname: WeiZhong
  surname: Yang
  fullname: Yang, WeiZhong
  organization: Chinese Center for Disease Control and Prevention, Beijing, China
– sequence: 36
  givenname: DeXin
  surname: Li
  fullname: Li, DeXin
  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China
– sequence: 37
  givenname: Guizhen
  surname: Wu
  fullname: Wu, Guizhen
  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China
– sequence: 38
  givenname: ZiJian
  surname: Feng
  fullname: Feng, ZiJian
  organization: Chinese Center for Disease Control and Prevention, Beijing, China
– sequence: 39
  givenname: George F
  surname: Gao
  fullname: Gao, George F
  organization: Chinese Center for Disease Control and Prevention, Beijing, China
– sequence: 40
  givenname: Yu
  surname: Wang
  fullname: Wang, Yu
  organization: Chinese Center for Disease Control and Prevention, Beijing, China
– sequence: 41
  givenname: Qi
  surname: Jin
  fullname: Jin, Qi
  organization: MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
– sequence: 42
  givenname: Mingbin
  surname: Liu
  fullname: Liu, Mingbin
  organization: Nanchang City Disease Control and Prevention, Nanchang, China
– sequence: 43
  givenname: Yuelong
  surname: Shu
  fullname: Shu, Yuelong
  email: yshu@cnic.org.cn
  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28175156$$DView record in Pascal Francis
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Issue 9918
Keywords Orthomyxoviridae
Epidemiology
Fatal course
Infection
Virus
Avian influenza
Medicine
Symptomatology
Influenzavirus A
Influenza A virus
Viral disease
Influenza A
Public health
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Copyright © 2014 Elsevier Ltd. All rights reserved.
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24812294 - Clin Infect Dis. 2014 Sep 1;59(5):748-50
24508318 - Lancet. 2014 Feb 22;383(9918):676-7
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Snippet Human infections with different avian influenza viruses—eg, H5N1, H9N2, and H7N9—have raised concerns about pandemic potential worldwide. We report the first...
Summary Background Human infections with different avian influenza viruses—eg, H5N1, H9N2, and H7N9—have raised concerns about pandemic potential worldwide. We...
Human infections with different avian influenza viruses--eg, H5N1, H9N2, and H7N9--have raised concerns about pandemic potential worldwide. We report the first...
Background Human infections with different avian influenza viruses-eg, H5N1, H9N2, and H7N9-have raised concerns about pandemic potential worldwide. We report...
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SubjectTerms Aged
Animals
Antiviral Agents - pharmacology
Avian flu
Bacterial infections
Binding sites
Biological and medical sciences
Blood
Cardiovascular disease
China
Commerce
Data collection
DNA, Viral - analysis
Drug resistance
Epidemiology
Exo-a-sialidase
Fatal Outcome
Fatalities
Female
General aspects
Genes
Genomes
Glutamate receptors
Glutamic acid
Glutamic Acid - metabolism
Hemagglutinins
Hospitals
Humans
Illnesses
Infections
Infectious diseases
Influenza
Influenza A
Influenza A virus - classification
Influenza A virus - drug effects
Influenza A virus - genetics
Influenza A Virus, H9N2 Subtype - isolation & purification
Influenza in Birds - virology
Influenza virus
Influenza, Human - diagnosis
Influenza, Human - drug therapy
Influenza, Human - virology
Internal Medicine
Leukocytes
Lysine
Lysine - metabolism
Medical laboratories
Medical sciences
Miscellaneous
Mortality
Multiple Organ Failure - virology
Mutation
Neuraminidase - antagonists & inhibitors
Pandemics
Patients
Phylogeny
Pneumonia
Poultry - virology
Proteins
Public health
Public health. Hygiene
Public health. Hygiene-occupational medicine
Research projects
Residues
Reverse Transcriptase Polymerase Chain Reaction
Review boards
RNA Replicase - metabolism
Sequence analysis
Sequence Analysis, DNA
Sputum
Surveillance
Trachea - virology
Viral Proteins - metabolism
Viruses
Title Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study
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Volume 383
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