Direct implantation of hair-follicle-associated pluripotent (HAP) stem cells repairs intracerebral hemorrhage and reduces neuroinflammation in mouse model

• Published in: PloS one Vol. 18; no. 1; p. e0280304
• Main Authors: Obara, Koya, Shirai, Kyoumi, Hamada, Yuko, Arakawa, Nobuko, Hasegawa, Ayami, Takaoka, Nanako, Aki, Ryoichi, Hoffman, Robert M., Amoh, Yasuyuki
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.01.2023; Public Library of Science (PLoS)
• Subjects: Anesthesia; Animal models; Animals; Astrocytes; Autografts; Biology and Life Sciences; Brain; Brain damage; Care and treatment; Cell Differentiation; Cerebral Hemorrhage - metabolism; Cerebral Hemorrhage - therapy; Disease Models, Animal; Edema; Embryo cells; Engineering and Technology; Follicles; Function analysis; Gene expression; Glial cells; Hair; Hair Follicle; Hair follicles; Health aspects; Hemorrhage; Implantation; Inflammation; Interleukin 10; Intracerebral hemorrhage; Medical research; Medicine and Health Sciences; Metastases; Mice; Mice, Inbred C57BL; Mice, Nude; Microglia; Microscopy; Monoclonal antibodies; Neuroinflammatory Diseases; Neuronal-glial interactions; Neurons; Oligodendrocytes; Peripheral nerves; Pluripotency; Pluripotent Stem Cells - metabolism; Proteins; Research and Analysis Methods; Sensorimotor system; Spinal cord injuries; Stem cell transplantation; Stem cells; Sutures; Therapeutics, Experimental; Transforming growth factor-b1; Transplantation; Tumors; Japan; United States > US; Temecula California; Germany

Intracerebral hemorrhage (ICH) is a leading cause of mortality with ineffective treatment. Hair-follicle-associated pluripotent (HAP) stem cells can differentiate into neurons, glial cells and many other types of cells. HAP stem cells have been shown to repair peripheral-nerve and spinal-cord injury...