Mitochondria-targeted ratiometric fluorescent probe for real time monitoring of pH in living cells

Pyridinium functioned 7-hydroxy coumarin was presented as the first mitochondria-targeted ratiometric fluorescent probe CP for real time monitoring pH in living cells. Compared with commercially available mitochondrial trackers, CP possesses high specificity to mitochondria in living cells as well a...

Full description

Saved in:

Bibliographic Details
Published in	Biomaterials Vol. 53; pp. 669 - 678
Main Authors	Wu, Ming-Yu, Li, Kun, Liu, Yan-Hong, Yu, Kang-Kang, Xie, Yong-Mei, Zhou, Xue-Dong, Yu, Xiao-Qi
Format	Journal Article
Language	English
Published	Netherlands Elsevier Ltd 01.06.2015
Subjects	7-Hydroxy coumarin acidification Advanced Basic Science apoptosis biocompatibility Cells (biology) Cellular confocal microscopy coumarin Dentistry Fluorescence fluorescent dyes Fluorescent Dyes - chemistry HeLa Cells Humans Hydrogen-Ion Concentration mitochondria Mitochondria - chemistry Mitochondria-targeted Monitoring Monitors pH probe Ratiometric Real time Spectrometry, Fluorescence Spectrophotometry, Ultraviolet stress response Surgical implants 7-Hydroxy coumarin Mitochondria-targeted Real time Ratiometric pH probe
Online Access	Get full text

Cover

Loading…

Abstract	Pyridinium functioned 7-hydroxy coumarin was presented as the first mitochondria-targeted ratiometric fluorescent probe CP for real time monitoring pH in living cells. Compared with commercially available mitochondrial trackers, CP possesses high specificity to mitochondria in living cells as well as good biocompatibility. Meanwhile, CP displays excellent pH sensitivity and anti-interference capability. Confocal image experiments confirm that CP can monitor mitochondrial pH changes associated with the mitochondrial acidification, cellular apoptosis and stress response efficiently in real time.
AbstractList	Abstract Pyridinium functioned 7-hydroxy coumarin was presented as the first mitochondria-targeted ratiometric fluorescent probe CP for real time monitoring pH in living cells. Compared with commercially available mitochondrial trackers, CP possesses high specificity to mitochondria in living cells as well as good biocompatibility. Meanwhile, CP displays excellent pH sensitivity and anti-interference capability. Confocal image experiments confirm that CP can monitor mitochondrial pH changes associated with the mitochondrial acidification, cellular apoptosis and stress response efficiently in real time. Pyridinium functioned 7-hydroxy coumarin was presented as the first mitochondria-targeted ratiometric fluorescent probe CP for real time monitoring pH in living cells. Compared with commercially available mitochondrial trackers, CP possesses high specificity to mitochondria in living cells as well as good biocompatibility. Meanwhile, CP displays excellent pH sensitivity and anti-interference capability. Confocal image experiments confirm that CP can monitor mitochondrial pH changes associated with the mitochondrial acidification, cellular apoptosis and stress response efficiently in real time. Pyridinium functioned 7-hydroxy coumarin was presented as the first mitochondria-targeted ratiometric fluorescent probe CP for real time monitoring pH in living cells. Compared with commercially available mitochondrial trackers, CP possesses high specificity to mitochondria in living cells as well as good biocompatibility. Meanwhile, CP displays excellent pH sensitivity and anti-interference capability. Confocal image experiments confirm that CP can monitor mitochondrial pH changes associated with the mitochondrial acidification, cellular apoptosis and stress response efficiently in real time.Pyridinium functioned 7-hydroxy coumarin was presented as the first mitochondria-targeted ratiometric fluorescent probe CP for real time monitoring pH in living cells. Compared with commercially available mitochondrial trackers, CP possesses high specificity to mitochondria in living cells as well as good biocompatibility. Meanwhile, CP displays excellent pH sensitivity and anti-interference capability. Confocal image experiments confirm that CP can monitor mitochondrial pH changes associated with the mitochondrial acidification, cellular apoptosis and stress response efficiently in real time.
Author	Zhou, Xue-Dong Yu, Xiao-Qi Li, Kun Yu, Kang-Kang Xie, Yong-Mei Wu, Ming-Yu Liu, Yan-Hong
Author_xml	– sequence: 1 givenname: Ming-Yu surname: Wu fullname: Wu, Ming-Yu organization: Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu 610064, PR China – sequence: 2 givenname: Kun surname: Li fullname: Li, Kun email: kli@scu.edu.cn organization: Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu 610064, PR China – sequence: 3 givenname: Yan-Hong surname: Liu fullname: Liu, Yan-Hong organization: Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu 610064, PR China – sequence: 4 givenname: Kang-Kang surname: Yu fullname: Yu, Kang-Kang organization: Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu 610064, PR China – sequence: 5 givenname: Yong-Mei surname: Xie fullname: Xie, Yong-Mei organization: State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China – sequence: 6 givenname: Xue-Dong surname: Zhou fullname: Zhou, Xue-Dong email: zhouxd@scu.edu.cn organization: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China – sequence: 7 givenname: Xiao-Qi surname: Yu fullname: Yu, Xiao-Qi email: xqyu@scu.edu.cn organization: Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu 610064, PR China
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25890762$$D View this record in MEDLINE/PubMed
BookMark	eNqNklFv1SAcxYmZcXfTr2CIT760Ai3Q-mDUbTqTGR_UZwL038m1hSvQJfv20txpzBKz-0RIzvlxwjkn6MgHDwi9oKSmhIpX29q4MOsM0ekp1YxQXhNWU9o8Qhvaya7iPeFHaENoy6peUHaMTlLaknInLXuCjhnveiIF2yDz2eVgfwQ_FFiVdbyGDAOOOpcnIEdn8TgtIUKy4DPexWAAjyHiCHrC2c2A5-ALIzp_jcOId5fYeTy5m_VuYZrSU_R4LDnh2d15ir5_uPh2dlldffn46ezdVWUF73MlhOVNS0nPba9Hpg3vh64hDQUJHdcMxq5tiWiNGU1jWs661lDGdcM4lb2wzSl6ueeWkL8WSFnNLq0JtIewJMXK5zXFRfmDUiolYbKVRBwgLUzKZdc8LBWyFV3PG1akz--ki5lhULvoZh1v1Z9iiuD1XmBjSCnC-FdCiVpXoLbq3xWodQWKMFVWUMxv75mty2ujPkftpsMQ53sElMZuHESVrANvYXARbFZDcIdh3tzD2Ml5Z_X0E24hbcMS_eqhKjFF1Nd1setgKSek9LoC3v8fcGiK3y1DAeY
CitedBy_id	crossref_primary_10_1016_j_dyepig_2016_08_058 crossref_primary_10_1016_j_molstruc_2022_133585 crossref_primary_10_1016_j_biomaterials_2016_05_029 crossref_primary_10_1016_j_talanta_2016_08_051 crossref_primary_10_1021_acs_analchem_6b01010 crossref_primary_10_1039_D3RA08269E crossref_primary_10_1016_j_bios_2016_10_090 crossref_primary_10_1016_j_snb_2021_129962 crossref_primary_10_1021_acssensors_0c02372 crossref_primary_10_1246_bcsj_20200157 crossref_primary_10_1016_j_snb_2021_130953 crossref_primary_10_1016_j_talanta_2018_09_026 crossref_primary_10_1039_D1CS00645B crossref_primary_10_1039_C8NJ01895B crossref_primary_10_1016_j_bios_2020_112791 crossref_primary_10_1016_j_snb_2022_132732 crossref_primary_10_1016_j_snb_2021_130397 crossref_primary_10_1016_j_snb_2019_127653 crossref_primary_10_1039_C6TB00433D crossref_primary_10_1021_acs_analchem_6b04417 crossref_primary_10_1039_C9CC07775H crossref_primary_10_1002_anie_201510721 crossref_primary_10_1016_j_aca_2020_03_040 crossref_primary_10_1039_C9CC02511A crossref_primary_10_1016_j_bios_2017_03_041 crossref_primary_10_1016_j_ijbiomac_2024_136165 crossref_primary_10_1021_acschembio_7b00647 crossref_primary_10_1002_bio_4312 crossref_primary_10_1039_C5CC07118F crossref_primary_10_1016_j_saa_2021_120554 crossref_primary_10_1039_D0CS00913J crossref_primary_10_1016_j_talanta_2019_03_066 crossref_primary_10_1039_D3SC03732K crossref_primary_10_1039_C6AN01942K crossref_primary_10_1021_acs_analchem_9b04709 crossref_primary_10_1016_j_talanta_2024_126171 crossref_primary_10_1007_s44211_022_00156_w crossref_primary_10_1016_j_foodchem_2021_130964 crossref_primary_10_1158_0008_5472_CAN_22_3398 crossref_primary_10_1039_D0AN01240H crossref_primary_10_1016_j_snb_2015_06_087 crossref_primary_10_1021_acs_joc_6b00034 crossref_primary_10_1002_asia_202001350 crossref_primary_10_1016_j_ijbiomac_2019_03_118 crossref_primary_10_1016_j_talanta_2024_126213 crossref_primary_10_1039_C9TB02551K crossref_primary_10_1021_acs_chemrev_9b00145 crossref_primary_10_1016_j_snb_2016_04_053 crossref_primary_10_1021_acs_chemrev_3c00573 crossref_primary_10_1016_j_dyepig_2024_112210 crossref_primary_10_1039_C8CC01031E crossref_primary_10_1039_D4CS00502C crossref_primary_10_1016_j_snb_2018_04_092 crossref_primary_10_1039_C7RA12920C crossref_primary_10_1039_C7DT00633K crossref_primary_10_1039_C9NR00093C crossref_primary_10_1088_2053_1591_ab6dac crossref_primary_10_1016_j_biomaterials_2015_11_047 crossref_primary_10_1021_acs_analchem_7b02164 crossref_primary_10_1039_D0DT02434A crossref_primary_10_1039_C8RA09770D crossref_primary_10_1021_acs_analchem_3c00171 crossref_primary_10_1016_j_inoche_2017_09_019 crossref_primary_10_1021_acsomega_4c07303 crossref_primary_10_1016_j_dyepig_2021_109625 crossref_primary_10_1021_acs_analchem_8b01345 crossref_primary_10_1021_acsomega_0c02621 crossref_primary_10_1039_C8PY01518J crossref_primary_10_1038_srep23061 crossref_primary_10_1021_acs_analchem_9b02782 crossref_primary_10_1039_C9DT03453F crossref_primary_10_1016_j_dyepig_2019_107610 crossref_primary_10_1039_D0TB01669A crossref_primary_10_1021_acsami_6b06331 crossref_primary_10_1002_cptc_202300212 crossref_primary_10_1016_j_snb_2020_128661 crossref_primary_10_1039_C9AY00473D crossref_primary_10_1021_acs_analchem_1c03075 crossref_primary_10_1039_D0TB01253J crossref_primary_10_1002_asia_202300308 crossref_primary_10_1016_j_snb_2017_06_065 crossref_primary_10_1021_acs_analchem_2c00574 crossref_primary_10_1039_C5TB02073E crossref_primary_10_1016_j_talanta_2019_120279 crossref_primary_10_1039_D0AN01141J crossref_primary_10_1016_j_saa_2024_124846 crossref_primary_10_1039_C6TB02524B crossref_primary_10_1021_acssensors_5b00165 crossref_primary_10_1039_C9CC03679B crossref_primary_10_1039_C9NR06347A crossref_primary_10_1016_j_snb_2023_133471 crossref_primary_10_1016_j_dyepig_2017_11_047 crossref_primary_10_1039_C9TB00043G crossref_primary_10_1002_bkcs_10888 crossref_primary_10_1021_acs_analchem_0c02298 crossref_primary_10_1021_acs_analchem_9b01861 crossref_primary_10_1039_C8AN01371C crossref_primary_10_1016_j_talanta_2024_126654 crossref_primary_10_1039_C8CC00299A crossref_primary_10_1039_D3AN00960B crossref_primary_10_1039_C9AN00422J crossref_primary_10_1021_acs_analchem_6b02398 crossref_primary_10_1016_j_cej_2021_133750 crossref_primary_10_1016_j_biomaterials_2020_120059 crossref_primary_10_1021_acs_analchem_7b03154 crossref_primary_10_1021_cbmi_3c00070 crossref_primary_10_1016_j_trac_2020_116092 crossref_primary_10_1016_j_cej_2022_140189 crossref_primary_10_1016_j_bbadis_2020_165808 crossref_primary_10_1002_chem_201905810 crossref_primary_10_1016_j_snb_2023_134255 crossref_primary_10_1021_acs_analchem_9b04065 crossref_primary_10_1039_D0SC00757A crossref_primary_10_1002_ange_201510721 crossref_primary_10_1016_j_aca_2023_341558 crossref_primary_10_1016_j_snb_2018_07_059 crossref_primary_10_1016_j_snb_2024_136912 crossref_primary_10_1021_acsami_0c15364 crossref_primary_10_1039_C9TB02302J crossref_primary_10_1021_acs_biomac_5b01394 crossref_primary_10_1016_j_saa_2021_120031 crossref_primary_10_1039_C7NJ01277B crossref_primary_10_1016_j_dyepig_2016_05_025 crossref_primary_10_1039_C9CC05759E crossref_primary_10_1016_j_dyepig_2016_12_052 crossref_primary_10_1016_j_dyepig_2022_110940 crossref_primary_10_3390_s18124407 crossref_primary_10_1021_acs_analchem_2c02177 crossref_primary_10_3390_molecules26072088 crossref_primary_10_1016_j_optmat_2019_03_001 crossref_primary_10_1016_j_tet_2024_133886 crossref_primary_10_1021_acsabm_9b00061 crossref_primary_10_1007_s10895_016_1861_9 crossref_primary_10_1021_acs_analchem_1c00264 crossref_primary_10_1039_D1NJ03933D crossref_primary_10_1039_D0TB02181D crossref_primary_10_1021_acsami_8b02206 crossref_primary_10_1039_C6CS00719H crossref_primary_10_1016_j_ab_2021_114545 crossref_primary_10_1246_cl_171073 crossref_primary_10_1016_j_dyepig_2018_05_051 crossref_primary_10_1016_j_saa_2022_121769 crossref_primary_10_1016_j_snb_2022_131656 crossref_primary_10_1016_j_dyepig_2016_12_043 crossref_primary_10_1002_bio_3043 crossref_primary_10_1021_acsabm_0c01546 crossref_primary_10_1016_j_bmc_2017_02_061 crossref_primary_10_1016_j_saa_2019_117435 crossref_primary_10_1002_adfm_201902240
Cites_doi	10.1016/j.abb.2007.03.034 10.1021/ja2004158 10.1039/an9608500587 10.1002/cbic.200900185 10.1016/j.ceca.2006.08.016 10.1002/anie.201301894 10.1039/C4CC02673J 10.1073/pnas.95.12.6803 10.1039/c2ra21995f 10.1074/jbc.274.41.29294 10.1039/c1an15042a 10.1083/jcb.91.3.227s 10.1002/anie.201202533 10.1039/C3CC46468G 10.1021/ja065759a 10.1039/c2cc33648k 10.1515/hsz-2012-0119 10.1039/C2OB26911B 10.1016/j.bbrc.2004.11.105 10.1161/CIRCRESAHA.112.265819 10.1021/ja506301n 10.1021/ac402409m 10.1038/nrm3028 10.1038/nmeth.1663 10.1039/c3cc46143b 10.1111/j.1432-1033.1978.tb12713.x 10.1016/0076-6879(95)60149-X 10.1021/ar700135m 10.1016/S0143416002001872 10.1074/jbc.M306766200 10.1021/ja202902d 10.1021/bi00451a026 10.1073/pnas.0710341105 10.1016/j.ceb.2005.06.011 10.1039/c3tc30759j 10.1152/physrev.1990.70.2.391 10.1021/bi00902a031 10.1016/S0021-9258(18)55235-2 10.1016/j.cbpa.2009.10.014 10.1056/NEJM197112092852402 10.1039/c4cc01390e 10.1016/0005-2728(83)90146-9 10.1016/S0092-8674(00)81728-6 10.1002/anie.201405742 10.1021/ja311688g
ContentType	Journal Article
Copyright	2015 Elsevier Ltd Elsevier Ltd Copyright © 2015 Elsevier Ltd. All rights reserved.
Copyright_xml	– notice: 2015 Elsevier Ltd – notice: Elsevier Ltd – notice: Copyright © 2015 Elsevier Ltd. All rights reserved.
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7QO 8FD FR3 P64 7SR 7TB 7U5 8BQ F28 JG9 L7M 7S9 L.6
DOI	10.1016/j.biomaterials.2015.02.113
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Biotechnology Research Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts Engineered Materials Abstracts Mechanical & Transportation Engineering Abstracts Solid State and Superconductivity Abstracts METADEX ANTE: Abstracts in New Technology & Engineering Materials Research Database Advanced Technologies Database with Aerospace AGRICOLA AGRICOLA - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic Engineering Research Database Biotechnology Research Abstracts Technology Research Database Biotechnology and BioEngineering Abstracts Materials Research Database Engineered Materials Abstracts Mechanical & Transportation Engineering Abstracts Solid State and Superconductivity Abstracts Advanced Technologies Database with Aerospace ANTE: Abstracts in New Technology & Engineering METADEX AGRICOLA AGRICOLA - Academic
DatabaseTitleList	MEDLINE Materials Research Database MEDLINE - Academic AGRICOLA Engineering Research Database
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine Engineering Dentistry
EISSN	1878-5905
EndPage	678
ExternalDocumentID	25890762 10_1016_j_biomaterials_2015_02_113 S0142961215002513 1_s2_0_S0142961215002513
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- --K --M .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 23N 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM 9JN AABNK AABXZ AAEDT AAEDW AAEPC AAHBH AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXUO AAYWO ABFNM ABGSF ABJNI ABMAC ABNUV ABUDA ABWVN ABXDB ABXRA ACDAQ ACGFS ACIUM ACNNM ACRLP ACRPL ACVFH ADBBV ADCNI ADEWK ADEZE ADMUD ADNMO ADTZH ADUVX AEBSH AECPX AEHWI AEIPS AEKER AENEX AEUPX AEVXI AEZYN AFFNX AFJKZ AFPUW AFRHN AFRZQ AFTJW AFXIZ AGCQF AGHFR AGQPQ AGRDE AGUBO AGYEJ AHHHB AHJVU AHPOS AI. AIEXJ AIGII AIIUN AIKHN AITUG AJUYK AKBMS AKRWK AKURH AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU APXCP ASPBG AVWKF AXJTR AZFZN BJAXD BKOJK BLXMC CS3 DU5 EBS EFJIC EFKBS EJD ENUVR EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMK HMO HVGLF HZ~ IHE J1W JJJVA KOM M24 M41 MAGPM MO0 N9A O-L O9- OAUVE OB- OM. OZT P-8 P-9 P2P PC. Q38 R2- RNS ROL RPZ SAE SCC SDF SDG SDP SES SEW SMS SPC SPCBC SSG SSM SST SSU SSZ T5K TN5 VH1 WH7 WUQ XPP XUV Z5R ZMT ~G- AACTN AAYOK AFCTW AFKWA AJOXV AMFUW PKN RIG AAIAV ABYKQ AJBFU DOVZS EFLBG AAYXX AGRNS BNPGV CITATION SSH CGR CUY CVF ECM EIF NPM 7X8 7QO 8FD FR3 P64 7SR 7TB 7U5 8BQ F28 JG9 L7M 7S9 L.6
ID	FETCH-LOGICAL-c659t-66c5341095c9af2ab59d83031e7e85a2ef844064bbfb3b45284b125a3251796c3
IEDL.DBID	.~1
ISSN	0142-9612 1878-5905
IngestDate	Tue Aug 05 11:17:56 EDT 2025 Thu Jul 10 17:05:47 EDT 2025 Tue Aug 05 10:46:57 EDT 2025 Sun Aug 24 04:14:41 EDT 2025 Mon Jul 21 06:05:33 EDT 2025 Thu Apr 24 22:55:56 EDT 2025 Tue Jul 01 03:47:48 EDT 2025 Fri Feb 23 02:31:35 EST 2024 Sun Feb 23 10:18:56 EST 2025 Tue Aug 26 17:20:08 EDT 2025
IsPeerReviewed	true
IsScholarly	true
Keywords	7-Hydroxy coumarin Mitochondria-targeted Real time Ratiometric pH probe
Language	English
License	Copyright © 2015 Elsevier Ltd. All rights reserved.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c659t-66c5341095c9af2ab59d83031e7e85a2ef844064bbfb3b45284b125a3251796c3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
PMID	25890762
PQID	1674689532
PQPubID	23479
PageCount	10
ParticipantIDs	proquest_miscellaneous_2101328415 proquest_miscellaneous_1770274706 proquest_miscellaneous_1732815783 proquest_miscellaneous_1674689532 pubmed_primary_25890762 crossref_primary_10_1016_j_biomaterials_2015_02_113 crossref_citationtrail_10_1016_j_biomaterials_2015_02_113 elsevier_sciencedirect_doi_10_1016_j_biomaterials_2015_02_113 elsevier_clinicalkeyesjournals_1_s2_0_S0142961215002513 elsevier_clinicalkey_doi_10_1016_j_biomaterials_2015_02_113
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2015-06-01
PublicationDateYYYYMMDD	2015-06-01
PublicationDate_xml	– month: 06 year: 2015 text: 2015-06-01 day: 01
PublicationDecade	2010
PublicationPlace	Netherlands
PublicationPlace_xml	– name: Netherlands
PublicationTitle	Biomaterials
PublicationTitleAlternate	Biomaterials
PublicationYear	2015
Publisher	Elsevier Ltd
Publisher_xml	– name: Elsevier Ltd
References	Neto, Correa, Silva (bib27) 2013; 3 Youle, Narendra (bib45) 2011; 12 Zhao, Li, Yan, Lam, Zhang, Zhao (bib33) 2013; 1 Shi, Li, Ma (bib46) 2012; 51 Hoye, Davoren, Wipe (bib25) 2008; 41 Ueno, Nagano (bib20) 2011; 8 Yang, Lowry, Xu, Escobedo, Sibrian-Vazquez, Wong (bib22) 2008; 105 Hou, Wu, Li, Yang, Yu, Xie (bib36) 2014; 50 McCormack, Halestrap, Denton (bib9) 1990; 70 Abad, Di Benedetto, Magalhaes, Filippin, Pozzan (bib16) 2004; 279 Yamada, Huzel (bib11) 1989; 28 Wu, Li, Li, Hou, Yu (bib21) 2014; 50 Chauhan, Burnett, Aylott (bib38) 2011; 136 Jiang, Fan, Liu, Cao, Qiao, Wang (bib35) 2013; 49 Ernster, Schatz (bib1) 1981; 91 Zhang, Wu, Fan, Li, Jiang, Wang (bib34) 2013; 11 Parker, Rees (bib37) 1960; 85 Li, Xiao, Cheng, Zheng, Huang, Zhang (bib18) 2014; 50 Lee, Park, Yi, Hong, Kim, Kang (bib19) 2014; 36 Nomura, Imai, Koumura, Arai, Nakagawa (bib12) 1999; 274 Ding, Yin (bib14) 2012; 393 Li, Zhang, Li, Liu, Xiao, Zhang (bib32) 2013; 85 Green (bib5) 1998; 94 Kubli, Gustafsson (bib13) 2012; 111 Lee, Han, Lee, Park, Kumar, Kang (bib47) 2013; 52 Nolan, Ryu, Jaworski, Feazell, Sheng, Lippard (bib29) 2006; 128 Moreno-Sanchez (bib10) 1983; 724 Partin, Schubert, Partin (bib15) 1971; 285 Wang, Xiao, Tian, Deng (bib42) 2013; 135 Porcelli, Ghelli, Zanna, Pinton, Rizzuto, Rugolo (bib17) 2005; 326 Crompton, Heid (bib7) 1978; 91 Heytler (bib40) 1963; 2 Hajnoczky, Csordas, Das, Garcia-Perez, Saotome, Sinha Roy (bib4) 2006; 40 Liu, Zhang, Chen, He, Guo (bib30) 2012; 48 Dodani, Leary, Cobine, Winge, Chang (bib31) 2011; 133 Voet, Judith, Charlotte (bib2) 2006 Garlid, Sun, Paucek, Woldegiorgis (bib8) 1995; 260 Dickinson, Srikun, Chang (bib26) 2010; 14 Yousif, Stewart, Kelley (bib28) 2009; 10 Wan, Chen, Shi, Li, Ma (bib23) 2014; 53 Llopis, Mccaffery, Miyawaki, Farquhar, Tsien (bib6) 1998; 95 Martin, Mahlke, Pfanner (bib24) 1991; 266 Kim, Rodriguez-Enriquez, Lemasters (bib44) 2007; 462 Hajnoczky, Csordás, Yi (bib3) 2002; 32 Jensen (bib39) 2005; 17 Tantama, Hung, Yellen (bib41) 2011; 133 Chang, Yuan, Mo, Chung (bib43) 1966; 6 Moreno-Sanchez (10.1016/j.biomaterials.2015.02.113_bib10) 1983; 724 Liu (10.1016/j.biomaterials.2015.02.113_bib30) 2012; 48 Zhao (10.1016/j.biomaterials.2015.02.113_bib33) 2013; 1 Ernster (10.1016/j.biomaterials.2015.02.113_bib1) 1981; 91 Crompton (10.1016/j.biomaterials.2015.02.113_bib7) 1978; 91 Hoye (10.1016/j.biomaterials.2015.02.113_bib25) 2008; 41 Llopis (10.1016/j.biomaterials.2015.02.113_bib6) 1998; 95 Wan (10.1016/j.biomaterials.2015.02.113_bib23) 2014; 53 Zhang (10.1016/j.biomaterials.2015.02.113_bib34) 2013; 11 Chang (10.1016/j.biomaterials.2015.02.113_bib43) 1966; 6 Lee (10.1016/j.biomaterials.2015.02.113_bib19) 2014; 36 Youle (10.1016/j.biomaterials.2015.02.113_bib45) 2011; 12 Heytler (10.1016/j.biomaterials.2015.02.113_bib40) 1963; 2 Yamada (10.1016/j.biomaterials.2015.02.113_bib11) 1989; 28 Partin (10.1016/j.biomaterials.2015.02.113_bib15) 1971; 285 Li (10.1016/j.biomaterials.2015.02.113_bib32) 2013; 85 Chauhan (10.1016/j.biomaterials.2015.02.113_bib38) 2011; 136 Abad (10.1016/j.biomaterials.2015.02.113_bib16) 2004; 279 Nolan (10.1016/j.biomaterials.2015.02.113_bib29) 2006; 128 Neto (10.1016/j.biomaterials.2015.02.113_bib27) 2013; 3 Wu (10.1016/j.biomaterials.2015.02.113_bib21) 2014; 50 Yousif (10.1016/j.biomaterials.2015.02.113_bib28) 2009; 10 Hou (10.1016/j.biomaterials.2015.02.113_bib36) 2014; 50 Shi (10.1016/j.biomaterials.2015.02.113_bib46) 2012; 51 Dickinson (10.1016/j.biomaterials.2015.02.113_bib26) 2010; 14 Voet (10.1016/j.biomaterials.2015.02.113_bib2) 2006 Parker (10.1016/j.biomaterials.2015.02.113_bib37) 1960; 85 McCormack (10.1016/j.biomaterials.2015.02.113_bib9) 1990; 70 Lee (10.1016/j.biomaterials.2015.02.113_bib47) 2013; 52 Nomura (10.1016/j.biomaterials.2015.02.113_bib12) 1999; 274 Hajnoczky (10.1016/j.biomaterials.2015.02.113_bib4) 2006; 40 Green (10.1016/j.biomaterials.2015.02.113_bib5) 1998; 94 Kim (10.1016/j.biomaterials.2015.02.113_bib44) 2007; 462 Wang (10.1016/j.biomaterials.2015.02.113_bib42) 2013; 135 Yang (10.1016/j.biomaterials.2015.02.113_bib22) 2008; 105 Dodani (10.1016/j.biomaterials.2015.02.113_bib31) 2011; 133 Porcelli (10.1016/j.biomaterials.2015.02.113_bib17) 2005; 326 Jiang (10.1016/j.biomaterials.2015.02.113_bib35) 2013; 49 Ueno (10.1016/j.biomaterials.2015.02.113_bib20) 2011; 8 Li (10.1016/j.biomaterials.2015.02.113_bib18) 2014; 50 Garlid (10.1016/j.biomaterials.2015.02.113_bib8) 1995; 260 Hajnoczky (10.1016/j.biomaterials.2015.02.113_bib3) 2002; 32 Martin (10.1016/j.biomaterials.2015.02.113_bib24) 1991; 266 Kubli (10.1016/j.biomaterials.2015.02.113_bib13) 2012; 111 Ding (10.1016/j.biomaterials.2015.02.113_bib14) 2012; 393 Jensen (10.1016/j.biomaterials.2015.02.113_bib39) 2005; 17 Tantama (10.1016/j.biomaterials.2015.02.113_bib41) 2011; 133
References_xml	– volume: 95 start-page: 6803 year: 1998 end-page: 6808 ident: bib6 article-title: Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins publication-title: Proc Natl Acad Sci U S A – volume: 462 start-page: 245 year: 2007 end-page: 253 ident: bib44 article-title: Selective degradation of mitochondria by mitophagy publication-title: Arch Biochem Biophys – volume: 17 start-page: 384 year: 2005 end-page: 388 ident: bib39 article-title: Control of mitochondrial shape publication-title: Curr Opin Cell Biol – volume: 41 start-page: 87 year: 2008 end-page: 97 ident: bib25 article-title: Targeting mitochondria publication-title: Acc Chem Res – volume: 50 start-page: 7184 year: 2014 end-page: 7187 ident: bib18 article-title: A near-infrared-emitting fluorescent probe for monitoring mitochondrial pH publication-title: Chem Commun – volume: 14 start-page: 50 year: 2010 end-page: 56 ident: bib26 article-title: Mitochondrial-targeted fluorescent probes for reactive oxygen species publication-title: Curr Opin Chem Biol – volume: 724 start-page: 278 year: 1983 end-page: 285 ident: bib10 article-title: Inhibition of oxidative phosphorylation by a Ca publication-title: Biochim Biophys Acta – volume: 128 start-page: 15517 year: 2006 end-page: 15528 ident: bib29 article-title: Zinspy sensors with enhanced dynamic range for imaging neuronal cell zinc uptake and mobilization publication-title: J Am Chem Soc – volume: 2 start-page: 357 year: 1963 end-page: 361 ident: bib40 article-title: Uncoupling of oxidative phosphorylation by carbonyl cyanide phenylhydrazones. I. Some characteristics of m-Cl-CCP action on mitochondria and chloroplasts publication-title: Biochemistry – volume: 48 start-page: 8365 year: 2012 end-page: 8367 ident: bib30 article-title: An excitation ratiometric Zn publication-title: Chem Commun – volume: 32 start-page: 363 year: 2002 end-page: 377 ident: bib3 article-title: Old players in a new role: mitochondria-associated membranes, VDAC, and ryanodine receptors as contributors to calcium signal propagation from endoplasmic reticulum to the mitochondria publication-title: Cell Calcium – volume: 91 start-page: 227 year: 1981 end-page: 255 ident: bib1 article-title: Mitochondria: a historical review publication-title: J Cell Biol – volume: 40 start-page: 553 year: 2006 end-page: 560 ident: bib4 article-title: Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca publication-title: Cell Calcium – volume: 260 start-page: 331 year: 1995 end-page: 348 ident: bib8 article-title: Mitochondrial cation transport systems publication-title: Methods Enzymol – volume: 28 start-page: 9714 year: 1989 end-page: 9718 ident: bib11 article-title: Calcium-binding ATPase inhibitor protein of bovine heart mitochondria. Role in ATP synthesis and effect of Ca publication-title: Biochemistry – volume: 36 start-page: 14136 year: 2014 end-page: 14142 ident: bib19 article-title: Mitochondria-immobilized pH-sensitive off–on fluorescent probe publication-title: J Am Soc Chem – volume: 52 start-page: 6206 year: 2013 end-page: 6209 ident: bib47 article-title: Two-color probe to monitor a wide range of pH values sin cells publication-title: Angew Chem Int Ed – volume: 85 start-page: 587 year: 1960 end-page: 600 ident: bib37 article-title: Correction of fluorescence spectra and measurement of fluorescence quantum efficiency publication-title: Analyst – volume: 111 start-page: 1208 year: 2012 end-page: 1221 ident: bib13 article-title: Mitochondria and mitophagy: the yin and yang of cell death control publication-title: Circ Res – volume: 279 start-page: 11521 year: 2004 end-page: 11529 ident: bib16 article-title: Mitochondrial pH monitored by a new engineered green fluorescent protein mutant publication-title: J Biol Chem – volume: 50 start-page: 183 year: 2014 end-page: 185 ident: bib21 article-title: A water-soluble near-infrared probe for colorimetric and ratiometric sensing of SO publication-title: Chem Commun – volume: 51 start-page: 6432 year: 2012 end-page: 6435 ident: bib46 article-title: A tunable ratiometric pH sensor based on carbon nanodots for the quantitative measurement of the intracellular pH of whole cells publication-title: Angew Chem Int Ed – volume: 133 start-page: 10034 year: 2011 end-page: 10037 ident: bib41 article-title: Imaging intracellular pH in live cells with a genetically encoded red fluorescent protein sensor publication-title: J Am Chem Soc – volume: 50 start-page: 8640 year: 2014 end-page: 8643 ident: bib36 article-title: Mitochondria-targeted colorimetric and fluorescent probes for hypochlorite and their applications for in vivo imaging publication-title: Chem Commun – volume: 274 start-page: 29294 year: 1999 end-page: 29302 ident: bib12 article-title: Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway publication-title: J Biol Chem – volume: 12 start-page: 9 year: 2011 end-page: 14 ident: bib45 article-title: Mechanisms of mitophagy publication-title: Nat Mol Cell Biol – volume: 91 start-page: 599 year: 1978 end-page: 608 ident: bib7 publication-title: Eur J Biochem – volume: 326 start-page: 799 year: 2005 end-page: 804 ident: bib17 article-title: pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant publication-title: Biochem Biophys Res Commun – volume: 266 start-page: 18051 year: 1991 end-page: 18057 ident: bib24 article-title: Role of an energized inner membrane in mitochondrial protein import. Delta psi drives the movement of presequences publication-title: J Biol Chem – volume: 136 start-page: 1799 year: 2011 end-page: 1801 ident: bib38 article-title: Dual-fluorophore ratiometric pH nanosensor with tuneable pKa and extended dynamic range publication-title: Analyst – volume: 133 start-page: 8606 year: 2011 end-page: 8616 ident: bib31 article-title: A targetable fluorescent sensor reveals that copper-deficient SCO1 and SCO2 patient cells prioritize mitochondrial copper homeostasis publication-title: J Am Chem Soc – volume: 49 start-page: 10620 year: 2013 end-page: 10622 ident: bib35 article-title: A near-infrared dye based on BODIPY for tracking morphology changes in mitochondria publication-title: Chem Commun – volume: 105 start-page: 8829 year: 2008 end-page: 8834 ident: bib22 article-title: Seminaphthofluorones are a family of water-soluble, low molecular weight, NIR-emitting fluorophores publication-title: Proc Natl Acad Sci U S A – volume: 285 start-page: 1339 year: 1971 end-page: 1343 ident: bib15 article-title: Mitochondrial ultrastructure in Reye's syndrome (encephalopathy and fatty degeneration of the viscera) publication-title: N Engl J Med – volume: 53 start-page: 10916 year: 2014 end-page: 10920 ident: bib23 article-title: Lysosomal pH rise during heat shock monitored by a lysosome-targeting near-infrared ratiometric fluorescent probe publication-title: Angew Chem Int Ed – volume: 6 start-page: 103 year: 1966 end-page: 109 ident: bib43 article-title: The effect of Chloroquine and emetine on tissue respiration and oxidative phosphorylation of liver mitochondria in rats publication-title: Acta Bioch Bioph Sin – volume: 3 start-page: 5291 year: 2013 end-page: 5301 ident: bib27 publication-title: RSC Adv – volume: 94 start-page: 695 year: 1998 end-page: 698 ident: bib5 article-title: Apoptotic pathways: the roads to ruin publication-title: Cell – year: 2006 ident: bib2 article-title: Fundamentals of Biochemistry – volume: 85 start-page: 9877 year: 2013 end-page: 9881 ident: bib32 article-title: Mitochondria-targeted reaction-based two-photon fluorescent probe for imaging of superoxide anion in live cells and in vivo publication-title: Anal Chem – volume: 70 start-page: 391 year: 1990 end-page: 425 ident: bib9 article-title: Role of calcium ions in regulation of mammalian intramitochondrial metabolism publication-title: Physiol Rev – volume: 11 start-page: 555 year: 2013 end-page: 558 ident: bib34 article-title: A BODIPY-based fluorescent dye for mitochondria in living cells, with low cytotoxicity and high photostability publication-title: Org Biomol Chem – volume: 135 start-page: 2903 year: 2013 end-page: 2906 ident: bib42 article-title: Activatable rotor for quantifying lysosomal viscosity in living cells publication-title: J Am Chem Soc – volume: 393 start-page: 547 year: 2012 end-page: 564 ident: bib14 article-title: Mitophagy: mechanisms, pathophysiological roles, and analysis publication-title: Biol Chem – volume: 8 start-page: 642 year: 2011 end-page: 645 ident: bib20 article-title: Fluorescent probes for sensing and imaging publication-title: Nat Methods – volume: 10 start-page: 1939 year: 2009 end-page: 1950 ident: bib28 article-title: Targeting mitochondria with organelle-specific compounds: strategies and applications publication-title: ChemBioChem – volume: 1 start-page: 4640 year: 2013 end-page: 4646 ident: bib33 article-title: A tetraphenylethene-substituted pyridinium salt with multiple functionalities: synthesis, stimuli-responsive emission, optical waveguide and specific mitochondrion imaging publication-title: J Mater Chem C – volume: 462 start-page: 245 year: 2007 ident: 10.1016/j.biomaterials.2015.02.113_bib44 article-title: Selective degradation of mitochondria by mitophagy publication-title: Arch Biochem Biophys doi: 10.1016/j.abb.2007.03.034 – volume: 133 start-page: 8606 year: 2011 ident: 10.1016/j.biomaterials.2015.02.113_bib31 article-title: A targetable fluorescent sensor reveals that copper-deficient SCO1 and SCO2 patient cells prioritize mitochondrial copper homeostasis publication-title: J Am Chem Soc doi: 10.1021/ja2004158 – volume: 85 start-page: 587 year: 1960 ident: 10.1016/j.biomaterials.2015.02.113_bib37 article-title: Correction of fluorescence spectra and measurement of fluorescence quantum efficiency publication-title: Analyst doi: 10.1039/an9608500587 – volume: 10 start-page: 1939 year: 2009 ident: 10.1016/j.biomaterials.2015.02.113_bib28 article-title: Targeting mitochondria with organelle-specific compounds: strategies and applications publication-title: ChemBioChem doi: 10.1002/cbic.200900185 – volume: 40 start-page: 553 year: 2006 ident: 10.1016/j.biomaterials.2015.02.113_bib4 article-title: Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis publication-title: Cell Calcium doi: 10.1016/j.ceca.2006.08.016 – volume: 52 start-page: 6206 year: 2013 ident: 10.1016/j.biomaterials.2015.02.113_bib47 article-title: Two-color probe to monitor a wide range of pH values sin cells publication-title: Angew Chem Int Ed doi: 10.1002/anie.201301894 – volume: 50 start-page: 8640 year: 2014 ident: 10.1016/j.biomaterials.2015.02.113_bib36 article-title: Mitochondria-targeted colorimetric and fluorescent probes for hypochlorite and their applications for in vivo imaging publication-title: Chem Commun doi: 10.1039/C4CC02673J – volume: 95 start-page: 6803 year: 1998 ident: 10.1016/j.biomaterials.2015.02.113_bib6 article-title: Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.95.12.6803 – volume: 3 start-page: 5291 year: 2013 ident: 10.1016/j.biomaterials.2015.02.113_bib27 publication-title: RSC Adv doi: 10.1039/c2ra21995f – volume: 274 start-page: 29294 year: 1999 ident: 10.1016/j.biomaterials.2015.02.113_bib12 article-title: Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway publication-title: J Biol Chem doi: 10.1074/jbc.274.41.29294 – volume: 136 start-page: 1799 year: 2011 ident: 10.1016/j.biomaterials.2015.02.113_bib38 article-title: Dual-fluorophore ratiometric pH nanosensor with tuneable pKa and extended dynamic range publication-title: Analyst doi: 10.1039/c1an15042a – volume: 91 start-page: 227 year: 1981 ident: 10.1016/j.biomaterials.2015.02.113_bib1 article-title: Mitochondria: a historical review publication-title: J Cell Biol doi: 10.1083/jcb.91.3.227s – volume: 51 start-page: 6432 year: 2012 ident: 10.1016/j.biomaterials.2015.02.113_bib46 article-title: A tunable ratiometric pH sensor based on carbon nanodots for the quantitative measurement of the intracellular pH of whole cells publication-title: Angew Chem Int Ed doi: 10.1002/anie.201202533 – volume: 50 start-page: 183 year: 2014 ident: 10.1016/j.biomaterials.2015.02.113_bib21 article-title: A water-soluble near-infrared probe for colorimetric and ratiometric sensing of SO2 derivatives in living cells publication-title: Chem Commun doi: 10.1039/C3CC46468G – volume: 128 start-page: 15517 year: 2006 ident: 10.1016/j.biomaterials.2015.02.113_bib29 article-title: Zinspy sensors with enhanced dynamic range for imaging neuronal cell zinc uptake and mobilization publication-title: J Am Chem Soc doi: 10.1021/ja065759a – volume: 48 start-page: 8365 year: 2012 ident: 10.1016/j.biomaterials.2015.02.113_bib30 article-title: An excitation ratiometric Zn2+ sensor with mitochondria-targetability for monitoring of mitochondrial Zn2+ release upon different stimulations publication-title: Chem Commun doi: 10.1039/c2cc33648k – volume: 393 start-page: 547 year: 2012 ident: 10.1016/j.biomaterials.2015.02.113_bib14 article-title: Mitophagy: mechanisms, pathophysiological roles, and analysis publication-title: Biol Chem doi: 10.1515/hsz-2012-0119 – volume: 11 start-page: 555 year: 2013 ident: 10.1016/j.biomaterials.2015.02.113_bib34 article-title: A BODIPY-based fluorescent dye for mitochondria in living cells, with low cytotoxicity and high photostability publication-title: Org Biomol Chem doi: 10.1039/C2OB26911B – volume: 326 start-page: 799 year: 2005 ident: 10.1016/j.biomaterials.2015.02.113_bib17 article-title: pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2004.11.105 – volume: 111 start-page: 1208 year: 2012 ident: 10.1016/j.biomaterials.2015.02.113_bib13 article-title: Mitochondria and mitophagy: the yin and yang of cell death control publication-title: Circ Res doi: 10.1161/CIRCRESAHA.112.265819 – volume: 36 start-page: 14136 year: 2014 ident: 10.1016/j.biomaterials.2015.02.113_bib19 article-title: Mitochondria-immobilized pH-sensitive off–on fluorescent probe publication-title: J Am Soc Chem doi: 10.1021/ja506301n – volume: 85 start-page: 9877 year: 2013 ident: 10.1016/j.biomaterials.2015.02.113_bib32 article-title: Mitochondria-targeted reaction-based two-photon fluorescent probe for imaging of superoxide anion in live cells and in vivo publication-title: Anal Chem doi: 10.1021/ac402409m – volume: 12 start-page: 9 year: 2011 ident: 10.1016/j.biomaterials.2015.02.113_bib45 article-title: Mechanisms of mitophagy publication-title: Nat Mol Cell Biol doi: 10.1038/nrm3028 – volume: 8 start-page: 642 year: 2011 ident: 10.1016/j.biomaterials.2015.02.113_bib20 article-title: Fluorescent probes for sensing and imaging publication-title: Nat Methods doi: 10.1038/nmeth.1663 – volume: 49 start-page: 10620 year: 2013 ident: 10.1016/j.biomaterials.2015.02.113_bib35 article-title: A near-infrared dye based on BODIPY for tracking morphology changes in mitochondria publication-title: Chem Commun doi: 10.1039/c3cc46143b – volume: 91 start-page: 599 year: 1978 ident: 10.1016/j.biomaterials.2015.02.113_bib7 publication-title: Eur J Biochem doi: 10.1111/j.1432-1033.1978.tb12713.x – volume: 260 start-page: 331 year: 1995 ident: 10.1016/j.biomaterials.2015.02.113_bib8 article-title: Mitochondrial cation transport systems publication-title: Methods Enzymol doi: 10.1016/0076-6879(95)60149-X – volume: 41 start-page: 87 year: 2008 ident: 10.1016/j.biomaterials.2015.02.113_bib25 article-title: Targeting mitochondria publication-title: Acc Chem Res doi: 10.1021/ar700135m – volume: 32 start-page: 363 year: 2002 ident: 10.1016/j.biomaterials.2015.02.113_bib3 article-title: Old players in a new role: mitochondria-associated membranes, VDAC, and ryanodine receptors as contributors to calcium signal propagation from endoplasmic reticulum to the mitochondria publication-title: Cell Calcium doi: 10.1016/S0143416002001872 – volume: 279 start-page: 11521 year: 2004 ident: 10.1016/j.biomaterials.2015.02.113_bib16 article-title: Mitochondrial pH monitored by a new engineered green fluorescent protein mutant publication-title: J Biol Chem doi: 10.1074/jbc.M306766200 – volume: 133 start-page: 10034 year: 2011 ident: 10.1016/j.biomaterials.2015.02.113_bib41 article-title: Imaging intracellular pH in live cells with a genetically encoded red fluorescent protein sensor publication-title: J Am Chem Soc doi: 10.1021/ja202902d – volume: 28 start-page: 9714 year: 1989 ident: 10.1016/j.biomaterials.2015.02.113_bib11 article-title: Calcium-binding ATPase inhibitor protein of bovine heart mitochondria. Role in ATP synthesis and effect of Ca2+ publication-title: Biochemistry doi: 10.1021/bi00451a026 – volume: 105 start-page: 8829 year: 2008 ident: 10.1016/j.biomaterials.2015.02.113_bib22 article-title: Seminaphthofluorones are a family of water-soluble, low molecular weight, NIR-emitting fluorophores publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0710341105 – volume: 17 start-page: 384 year: 2005 ident: 10.1016/j.biomaterials.2015.02.113_bib39 article-title: Control of mitochondrial shape publication-title: Curr Opin Cell Biol doi: 10.1016/j.ceb.2005.06.011 – volume: 1 start-page: 4640 year: 2013 ident: 10.1016/j.biomaterials.2015.02.113_bib33 article-title: A tetraphenylethene-substituted pyridinium salt with multiple functionalities: synthesis, stimuli-responsive emission, optical waveguide and specific mitochondrion imaging publication-title: J Mater Chem C doi: 10.1039/c3tc30759j – volume: 70 start-page: 391 year: 1990 ident: 10.1016/j.biomaterials.2015.02.113_bib9 article-title: Role of calcium ions in regulation of mammalian intramitochondrial metabolism publication-title: Physiol Rev doi: 10.1152/physrev.1990.70.2.391 – volume: 2 start-page: 357 year: 1963 ident: 10.1016/j.biomaterials.2015.02.113_bib40 article-title: Uncoupling of oxidative phosphorylation by carbonyl cyanide phenylhydrazones. I. Some characteristics of m-Cl-CCP action on mitochondria and chloroplasts publication-title: Biochemistry doi: 10.1021/bi00902a031 – volume: 266 start-page: 18051 year: 1991 ident: 10.1016/j.biomaterials.2015.02.113_bib24 article-title: Role of an energized inner membrane in mitochondrial protein import. Delta psi drives the movement of presequences publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)55235-2 – volume: 14 start-page: 50 year: 2010 ident: 10.1016/j.biomaterials.2015.02.113_bib26 article-title: Mitochondrial-targeted fluorescent probes for reactive oxygen species publication-title: Curr Opin Chem Biol doi: 10.1016/j.cbpa.2009.10.014 – volume: 285 start-page: 1339 year: 1971 ident: 10.1016/j.biomaterials.2015.02.113_bib15 article-title: Mitochondrial ultrastructure in Reye's syndrome (encephalopathy and fatty degeneration of the viscera) publication-title: N Engl J Med doi: 10.1056/NEJM197112092852402 – volume: 50 start-page: 7184 year: 2014 ident: 10.1016/j.biomaterials.2015.02.113_bib18 article-title: A near-infrared-emitting fluorescent probe for monitoring mitochondrial pH publication-title: Chem Commun doi: 10.1039/c4cc01390e – year: 2006 ident: 10.1016/j.biomaterials.2015.02.113_bib2 – volume: 724 start-page: 278 year: 1983 ident: 10.1016/j.biomaterials.2015.02.113_bib10 article-title: Inhibition of oxidative phosphorylation by a Ca2+-induced diminution of the adenine nucleotide translocator publication-title: Biochim Biophys Acta doi: 10.1016/0005-2728(83)90146-9 – volume: 94 start-page: 695 year: 1998 ident: 10.1016/j.biomaterials.2015.02.113_bib5 article-title: Apoptotic pathways: the roads to ruin publication-title: Cell doi: 10.1016/S0092-8674(00)81728-6 – volume: 53 start-page: 10916 year: 2014 ident: 10.1016/j.biomaterials.2015.02.113_bib23 article-title: Lysosomal pH rise during heat shock monitored by a lysosome-targeting near-infrared ratiometric fluorescent probe publication-title: Angew Chem Int Ed doi: 10.1002/anie.201405742 – volume: 135 start-page: 2903 year: 2013 ident: 10.1016/j.biomaterials.2015.02.113_bib42 article-title: Activatable rotor for quantifying lysosomal viscosity in living cells publication-title: J Am Chem Soc doi: 10.1021/ja311688g – volume: 6 start-page: 103 year: 1966 ident: 10.1016/j.biomaterials.2015.02.113_bib43 article-title: The effect of Chloroquine and emetine on tissue respiration and oxidative phosphorylation of liver mitochondria in rats publication-title: Acta Bioch Bioph Sin
SSID	ssj0014042
Score	2.5355952
Snippet	Pyridinium functioned 7-hydroxy coumarin was presented as the first mitochondria-targeted ratiometric fluorescent probe CP for real time monitoring pH in... Abstract Pyridinium functioned 7-hydroxy coumarin was presented as the first mitochondria-targeted ratiometric fluorescent probe CP for real time monitoring pH...
SourceID	proquest pubmed crossref elsevier
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	669
SubjectTerms	7-Hydroxy coumarin acidification Advanced Basic Science apoptosis biocompatibility Cells (biology) Cellular confocal microscopy coumarin Dentistry Fluorescence fluorescent dyes Fluorescent Dyes - chemistry HeLa Cells Humans Hydrogen-Ion Concentration mitochondria Mitochondria - chemistry Mitochondria-targeted Monitoring Monitors pH probe Ratiometric Real time Spectrometry, Fluorescence Spectrophotometry, Ultraviolet stress response Surgical implants
Title	Mitochondria-targeted ratiometric fluorescent probe for real time monitoring of pH in living cells
URI	https://www.clinicalkey.com/#!/content/1-s2.0-S0142961215002513 https://www.clinicalkey.es/playcontent/1-s2.0-S0142961215002513 https://dx.doi.org/10.1016/j.biomaterials.2015.02.113 https://www.ncbi.nlm.nih.gov/pubmed/25890762 https://www.proquest.com/docview/1674689532 https://www.proquest.com/docview/1732815783 https://www.proquest.com/docview/1770274706 https://www.proquest.com/docview/2101328415
Volume	53
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3Na9swFBelg7EdxtZ9NN1WNNhVi_VlW4wdSlnJNtLTCr0JS5YgI3VCk1z3t_c9yQ4dW0pgxwQ92db7-ll--j1CPvIiqti0nMlGS6Z44VltBGcitMq1RviYzq1NL8vJlfp-ra8PyPlwFgbLKvvYn2N6itb9P-N-NcfL2WyMZUnCIAGWTkAZGT-VqtDKP_3elnkge4zIZYyC4eiBeDTVeOER92adVY1lXhr5OzmXu5LULhCaktHFc_KsR5H0LN_oC3IQuiPy9B634BF5PO2_mr8kbgpuC2Gua-EWWK79Di1Nur_BjlqexvlmcZuZnSj2mAkUwCwFQDmn2H2e3iTXx5npItLlhM46Op_hZgTFrf_VK3J18fXn-YT1vRWYL7VZs7L0GhIYACxvmigap01bQzrjoQq1bkSItYJcr5yLTjqlIYs5wEKNTBRnpZevyWG36MIxoUYF45yrfQQw4zXM5XVwSpkqwOuPiCNihsW0vicex_4XcztUmP2y9xVhURG2EPByIkdEbmWXmX5jL6nPg87scMAUQqKFLLGXdPUv6bDqvXtluV0JW9i_LHBEvmwl_zDiva_8YTAwC16O-mu6sNjAFctKlbXRUjwwBnmXOETgh-apqrQPUZS7xwiO399qQHYj8iZb-Xbtha5NAfnz5D-f9C15gr9yzd07cri-3YT3gO7W7jS57yl5dPbtx-TyDkfCUPs
linkProvider	Elsevier
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VIvE4ICgUlqeR4Bg2duwkFuoBAdWWdntqpd5M7DjSom121ewKceFP8QeZcZJVEWy1Euo1yTjJzOSbz_F4BuANjytZFSWPkkIlkeSxi3IteCR8KW2phavCvrXxcTo6lV_O1NkW_Or3wlBaZYf9LaYHtO6ODDttDueTyZDSkoSmAlgqEOW-g_Wh__Ed523N3sEnNPJbIfY_n3wcRV1rgcilSi-iNHUK8Rv5hdNFJQqrdJkjmnOf-VwVwle5xFAnra1sYqVCELdIBYokVPhKXYLj3oCbEuGC2ia8-7nKK6FyNaLNmxQRPV5f6TQkldGe-mLR-hbllSkqGMp5si4qrmO9Ifrt34d7HW1lH1rNPIAtX-_A3UvFDHfg1rhbpn8Idow4gbhal_gIUZts7ksWnO2cWng5Vk2Xs4u2lBSjpjaeIXtmyGCnjNrds_OANTQym1VsPmKTmk0n9PeD0VpD8whOr0Xju7Bdz2r_BJiWXltrc1che3IKx3LKWyl15nG-JaoB6F6ZxnWVzqnhxtT0KW3fzGVDGDKEiQXOhpIBJCvZeVvvYyOp973NTL-jFTHYYFjaSDr7l7RvOjhpDDeNMLH5y-UHsLeS_OOr2fjOr3sHMwgrZL-i9rMl3jHNZJprlYgrrqFCTxwh_6pxsiz8-IjT9dcITgt-OVLJATxuvXyle6FyHWPAfvqfb_oKbo9Oxkfm6OD48BncoTNtwt9z2F5cLP0LpJYL-zJ8ygy-Xjd2_Aa5uorn
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mitochondria-targeted+ratiometric+fluorescent+probe+for+real+time+monitoring+of+pH+in+living+cells&rft.jtitle=Biomaterials&rft.au=Wu%2C+Ming-Yu&rft.au=Li%2C+Kun&rft.au=Liu%2C+Yan-Hong&rft.au=Yu%2C+Kang-Kang&rft.date=2015-06-01&rft.pub=Elsevier+Ltd&rft.issn=0142-9612&rft.eissn=1878-5905&rft.volume=53&rft.spage=669&rft.epage=678&rft_id=info:doi/10.1016%2Fj.biomaterials.2015.02.113&rft.externalDocID=S0142961215002513
thumbnail_m	http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F01429612%2FS0142961215X0010X%2Fcov150h.gif