Regulation of autophagy by amino acids and MTOR-dependent signal transduction

Amino acids not only participate in intermediary metabolism but also stimulate insulin-mechanistic target of rapamycin (MTOR)-mediated signal transduction which controls the major metabolic pathways. Among these is the pathway of autophagy which takes care of the degradation of long-lived proteins a...

Full description

Saved in:
Bibliographic Details
Published inAmino acids Vol. 47; no. 10; pp. 2037 - 2063
Main Authors Meijer, Alfred J, Lorin, Séverine, Blommaart, Edward F, Codogno, Patrice
Format Journal Article
LanguageEnglish
Published Vienna Springer Vienna 01.10.2015
Springer Nature B.V
Subjects
Amino acids
Amino Acids - metabolism
Analytical Chemistry
Animals
Autophagy
Biochemical Engineering
biochemical pathways
Biochemistry
Biomedical and Life Sciences
Cell survival
cell viability
Control
etiology
Humans
Life Sciences
Metabolic pathways
Metabolism
Neurobiology
Organelles
Pathology
Pathways
proteins
Proteomics
Rapamycin
Redundant
Review
Review Article
Signal Transduction
Stimulation
Survival
TOR protein
TOR Serine-Threonine Kinases - metabolism
Lysosomes
Mitochondria
Rapamycin
Leucine
Glutamine
Online AccessGet full text

Cover

Abstract Amino acids not only participate in intermediary metabolism but also stimulate insulin-mechanistic target of rapamycin (MTOR)-mediated signal transduction which controls the major metabolic pathways. Among these is the pathway of autophagy which takes care of the degradation of long-lived proteins and of the elimination of damaged or functionally redundant organelles. Proper functioning of this process is essential for cell survival. Dysregulation of autophagy has been implicated in the etiology of several pathologies. The history of the studies on the interrelationship between amino acids, MTOR signaling and autophagy is the subject of this review. The mechanisms responsible for the stimulation of MTOR-mediated signaling, and the inhibition of autophagy, by amino acids have been studied intensively in the past but are still not completely clarified. Recent developments in this field are discussed.
AbstractList Amino acids not only participate in intermediary metabolism but also stimulate insulin-mechanistic target of rapamycin (MTOR)-mediated signal transduction which controls the major metabolic pathways. Among these is the pathway of autophagy which takes care of the degradation of long-lived proteins and of the elimination of damaged or functionally redundant organelles. Proper functioning of this process is essential for cell survival. Dysregulation of autophagy has been implicated in the etiology of several pathologies. The history of the studies on the interrelationship between amino acids, MTOR signaling and autophagy is the subject of this review. The mechanisms responsible for the stimulation of MTOR-mediated signaling, and the inhibition of autophagy, by amino acids have been studied intensively in the past but are still not completely clarified. Recent developments in this field are discussed.
Amino acids not only participate in intermediary metabolism but also stimulate insulin-mechanistic target of rapamycin (MTOR)-mediated signal transduction which controls the major metabolic pathways. Among these is the pathway of autophagy which takes care of the degradation of long-lived proteins and of the elimination of damaged or functionally redundant organelles. Proper functioning of this process is essential for cell survival. Dysregulation of autophagy has been implicated in the etiology of several pathologies. The history of the studies on the interrelationship between amino acids, MTOR signaling and autophagy is the subject of this review. The mechanisms responsible for the stimulation of MTOR-mediated signaling, and the inhibition of autophagy, by amino acids have been studied intensively in the past but are still not completely clarified. Recent developments in this field are discussed.Amino acids not only participate in intermediary metabolism but also stimulate insulin-mechanistic target of rapamycin (MTOR)-mediated signal transduction which controls the major metabolic pathways. Among these is the pathway of autophagy which takes care of the degradation of long-lived proteins and of the elimination of damaged or functionally redundant organelles. Proper functioning of this process is essential for cell survival. Dysregulation of autophagy has been implicated in the etiology of several pathologies. The history of the studies on the interrelationship between amino acids, MTOR signaling and autophagy is the subject of this review. The mechanisms responsible for the stimulation of MTOR-mediated signaling, and the inhibition of autophagy, by amino acids have been studied intensively in the past but are still not completely clarified. Recent developments in this field are discussed.
Author Lorin, Séverine
Blommaart, Edward F
Codogno, Patrice
Meijer, Alfred J
Author_xml – sequence: 1
  fullname: Meijer, Alfred J
– sequence: 2
  fullname: Lorin, Séverine
– sequence: 3
  fullname: Blommaart, Edward F
– sequence: 4
  fullname: Codogno, Patrice
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24880909$$D View this record in MEDLINE/PubMed
BookMark eNqNkk1LHTEYhUOx1KvtD-imHejGzdR8J7MpiGhbUASr65BJMmNkbnKbzBTuvzfjaLEurFkkizzncN6PPbATYnAAfETwK4JQHOZyYV5DRGskOKvpG7BClMgao6bZASvYkKamlKFdsJfzLYQIS8TfgV1MpYQNbFbg_NL106BHH0MVu0pPY9zc6H5btdtKr32IlTbe5koHW51fXVzW1m1csC6MVfZ90EM1Jh2yncxs8R687fSQ3YeHdx9cn55cHf-ozy6-_zw-OqsNZ81YU4OcxQITiwwm3KHWsa4lummlsB2DFhvhJOctEwgzDbkUjFpJrJW2g7Aj--Db4ruZ2rWzpsRJelCb5Nc6bVXUXv37E_yN6uMfRZksLcPF4ODBIMXfk8ujWvts3DDo4OKUFYblYEYl_y9aOo-hYGUQr0ARbwiTYg7w5Rl6G6dU-nlPMckIRqRQn57W-bfAx_kVQCyASTHn5Dpl_Hg_zVK2HxSCat4UtWyKKpsy52WKFiV6pnw0f0mDF00ubOhdehL6BdHnRdTpqHSffFbXvzBEHM77CAkjdwPM19M
CitedBy_id crossref_primary_10_1080_15548627_2020_1728095
crossref_primary_10_1038_s41467_021_27426_x
crossref_primary_10_1016_j_canlet_2021_09_010
crossref_primary_10_3389_fnins_2019_01352
crossref_primary_10_1016_j_abb_2020_108594
crossref_primary_10_2174_1389450124666230417104325
crossref_primary_10_1007_s12035_022_02846_y
crossref_primary_10_1007_s11033_023_08641_9
crossref_primary_10_1016_j_bbadis_2022_166400
crossref_primary_10_1016_j_jbc_2021_101003
crossref_primary_10_20900_agmr20200002
crossref_primary_10_1016_j_metabol_2015_11_010
crossref_primary_10_3389_fcell_2020_590192
crossref_primary_10_1016_j_bbrc_2018_11_133
crossref_primary_10_1080_15548627_2021_1968228
crossref_primary_10_1038_ncomms14124
crossref_primary_10_1002_jcp_27523
crossref_primary_10_1080_01635581_2023_2270215
crossref_primary_10_1111_obr_13221
crossref_primary_10_18632_oncotarget_18995
crossref_primary_10_3390_ijms20102524
crossref_primary_10_1017_S0007114516003949
crossref_primary_10_3389_fcell_2023_1127618
crossref_primary_10_1152_japplphysiol_00542_2020
crossref_primary_10_1093_jas_skae257
crossref_primary_10_1016_j_jmb_2020_01_024
crossref_primary_10_1007_s10565_016_9374_5
crossref_primary_10_1016_j_smim_2023_101814
crossref_primary_10_1111_acel_12876
crossref_primary_10_1016_j_neuropharm_2022_109203
crossref_primary_10_1016_j_tice_2025_102832
crossref_primary_10_1093_jee_toz287
crossref_primary_10_1242_dmm_049280
crossref_primary_10_1016_j_yclnex_2020_07_003
crossref_primary_10_3389_fnmol_2017_00170
crossref_primary_10_3389_fonc_2020_599915
crossref_primary_10_18632_oncotarget_25708
crossref_primary_10_1016_j_freeradbiomed_2021_04_025
crossref_primary_10_3390_cells12081156
crossref_primary_10_3390_nu11122923
crossref_primary_10_1186_s12929_021_00715_9
crossref_primary_10_3389_fpls_2020_579875
crossref_primary_10_1080_15384101_2017_1380134
crossref_primary_10_1016_j_ejmech_2024_117180
crossref_primary_10_1038_npjamd_2015_8
crossref_primary_10_1038_ncomms15637
crossref_primary_10_18632_oncotarget_15828
crossref_primary_10_3389_fcimb_2020_00280
crossref_primary_10_3389_fendo_2022_903836
crossref_primary_10_1080_11101849_2022_2031811
crossref_primary_10_3390_ijms25042139
crossref_primary_10_1002_iub_2324
crossref_primary_10_1016_j_bbamcr_2018_12_001
crossref_primary_10_3390_cells8111322
crossref_primary_10_1186_s12885_024_13374_4
crossref_primary_10_1016_j_smim_2023_101838
crossref_primary_10_1038_s41598_020_68607_w
crossref_primary_10_1038_s41598_022_20251_2
crossref_primary_10_3389_fnagi_2017_00173
crossref_primary_10_1089_dna_2014_2755
crossref_primary_10_1016_j_pneurobio_2017_05_001
crossref_primary_10_1158_1541_7786_MCR_22_0843
crossref_primary_10_1080_15548627_2017_1415189
crossref_primary_10_1038_ncb3360
crossref_primary_10_1038_s41392_023_01608_z
crossref_primary_10_1093_cvr_cvx017
crossref_primary_10_1038_ncb3366
crossref_primary_10_1152_ajpcell_00176_2017
crossref_primary_10_1161_ATVBAHA_123_319037
crossref_primary_10_1016_j_theriogenology_2016_09_016
crossref_primary_10_1093_nutrit_nuy037
crossref_primary_10_1126_sciadv_aau5106
crossref_primary_10_1016_j_jplph_2016_10_016
crossref_primary_10_1002_jcp_25672
crossref_primary_10_1007_s00726_022_03203_y
crossref_primary_10_1038_pr_2017_88
crossref_primary_10_3390_metabo12070574
crossref_primary_10_1371_journal_pone_0153587
crossref_primary_10_1038_s41598_019_45500_9
crossref_primary_10_1038_s41574_018_0009_1
crossref_primary_10_1016_j_resmic_2017_04_005
crossref_primary_10_1093_nutrit_nuv052
crossref_primary_10_1038_cdd_2014_171
crossref_primary_10_1007_s00726_016_2352_7
crossref_primary_10_1152_ajpcell_00129_2016
crossref_primary_10_3390_cells8111349
crossref_primary_10_3390_nu8040215
crossref_primary_10_1016_j_ejphar_2023_175903
crossref_primary_10_1016_j_bbrc_2019_10_114
crossref_primary_10_1155_2021_6347792
crossref_primary_10_3390_ijms22020966
crossref_primary_10_1042_BCJ20160822
crossref_primary_10_1007_s10753_020_01324_8
crossref_primary_10_3389_fonc_2020_602661
crossref_primary_10_1093_jas_skae141
crossref_primary_10_2174_1389203720666190125110150
crossref_primary_10_1128_mBio_01651_19
crossref_primary_10_1210_clinem_dgab538
crossref_primary_10_1051_jbio_2016005
crossref_primary_10_1007_s00726_020_02857_w
crossref_primary_10_3390_sym13030455
crossref_primary_10_1080_15548627_2015_1053680
crossref_primary_10_3389_fcell_2019_00179
crossref_primary_10_1080_28347056_2024_2304348
crossref_primary_10_2174_2211556009666191231155927
crossref_primary_10_3389_fnagi_2018_00004
crossref_primary_10_1002_jbt_22552
crossref_primary_10_1007_s00109_021_02117_8
crossref_primary_10_1016_j_cmet_2021_08_018
crossref_primary_10_3389_fnut_2019_00062
crossref_primary_10_1371_journal_pone_0313302
crossref_primary_10_3892_etm_2018_5830
crossref_primary_10_1007_s11357_024_01337_3
crossref_primary_10_31857_S0301179824040052
crossref_primary_10_1021_acs_jafc_8b02145
crossref_primary_10_21769_BioProtoc_2836
Cites_doi 10.1093/nar/gkt563
10.1007/s00726-008-0225-4
10.3803/EnM.2013.28.1.6
10.1016/j.tibs.2010.07.007
10.7554/eLife.00947
10.1074/jbc.M110.133579
10.2337/db10-1246
10.1073/pnas.0912074106
10.1126/science.8385367
10.1016/j.cmet.2008.03.002
10.1101/gad.1199104
10.1038/cr.2012.68
10.1073/pnas.012485299
10.1371/journal.pone.0000690
10.1038/nature11910
10.2174/1874609810801010004
10.1016/j.cell.2013.04.023
10.1128/MCB.21.13.4347-4368.2001
10.1074/jbc.M113.456228
10.1152/ajpendo.00067.2012
10.1074/jbc.273.43.28178
10.1046/j.1432-1033.2002.03074.x
10.1126/science.1204592
10.1016/j.molcel.2012.08.001
10.1083/jcb.201107033
10.1016/S0076-6879(08)03603-3
10.1159/000351979
10.1093/hmg/ddl239
10.1126/science.1207056
10.1046/j.1432-1033.2002.03069.x
10.4161/auto.19469
10.1074/jbc.274.2.1058
10.1111/j.1432-1033.1989.tb14782.x
10.4161/auto.7.10.16660
10.1152/ajpendo.91002.2008
10.1042/bj2870217
10.1016/j.tibs.2013.12.001
10.1042/BJ20061881
10.1073/pnas.0712145105
10.1016/S0014-5793(99)00304-X
10.1161/01.RES.0000261924.76669.36
10.1080/10408360903044068
10.1091/mbc.E11-12-1034
10.1016/j.jnutbio.2012.04.018
10.1128/MCB.01082-08
10.1016/j.semcancer.2013.05.007
10.4161/auto.26058
10.1074/jbc.272.35.21661
10.1016/j.cmet.2014.02.010
10.1016/j.cmet.2011.01.007
10.4161/auto.6.4.11863
10.1038/ncb0808-881
10.1016/j.molcel.2010.01.031
10.1038/ncb2822
10.1016/j.molcel.2013.09.016
10.1073/pnas.1112848109
10.1046/j.1365-2443.2003.00615.x
10.3389/fgene.2012.00177
10.1093/emboj/20.21.5971
10.2353/ajpath.2006.051066
10.1038/nature02866
10.1038/nature12040
10.4161/auto.23323
10.1371/journal.pone.0087161
10.1038/cr.2013.153
10.1007/s10059-013-0138-2
10.1074/jbc.M414499200
10.1016/j.tcb.2013.07.008
10.1038/ncb2536
10.4161/auto.6.8.13092
10.1007/BF01923509
10.1146/annurev-pharmtox-010611-134537
10.1016/j.phrs.2012.09.003
10.1074/jbc.C500169200
10.1074/jbc.M410755200
10.1042/bst0220508
10.1007/s00726-011-0981-4
10.1158/0008-5472.CAN-09-2266
10.1146/annurev.nutr.27.061406.093749
10.4161/cc.22632
10.1016/j.semcancer.2013.06.007
10.1152/ajpendo.00153.2003
10.1042/bj3130697
10.1074/jbc.271.51.32523
10.1111/j.1432-1033.1997.0240a.x
10.1074/jbc.M107694200
10.1016/j.cell.2014.01.024
10.1016/S0014-5793(02)02815-6
10.1042/bj2780887
10.1146/annurev-pharmtox-010611-134717
10.1126/science.1232044
10.1111/j.1748-1716.2006.01542.x
10.1073/pnas.76.7.3169
10.1038/ncb1537
10.4161/auto.23066
10.1016/0014-4827(82)90020-9
10.1085/jgp.201210930
10.4161/auto.27344
10.1038/cdd.2013.174
10.1074/jbc.M807135200
10.1046/j.1365-2958.1999.01538.x
10.2337/diabetes.50.2.353
10.1152/ajpendo.00487.2003
10.1038/cr.2013.168
10.1016/0304-4165(80)90141-5
10.1074/jbc.M900301200
10.1074/jbc.M512792200
10.1016/j.molcel.2008.06.001
10.4161/auto.21544
10.1074/jbc.M111.249631
10.1111/j.1432-1033.1996.00564.x-i2
10.1016/j.molcel.2012.05.043
10.1042/BST20110684
10.1016/j.febslet.2006.04.068
10.1146/annurev-biochem-062209-094414
10.1023/A:1026486801018
10.4161/auto.24083
10.1073/pnas.79.6.1889
10.4161/auto.25573
10.1016/j.gde.2012.12.005
10.1126/science.1066015
10.1042/bj20030826
10.1016/j.bbrc.2014.01.117
10.1016/j.cell.2011.10.026
10.1016/j.cell.2008.11.044
10.1034/j.1600-0854.2002.31204.x
10.1159/000334283
10.1038/ncb2757
10.1089/ars.2013.5410
10.1126/science.1063518
10.1038/288187a0
10.2174/1566524011313040005
10.1091/mbc.E14-01-0021
10.1074/jbc.M900573200
10.1016/j.cell.2010.02.024
10.1006/phrs.1996.0108
10.1006/dbio.2001.0461
10.1083/jcb.35.2.C11
10.1002/recl.19040230504
10.1007/978-1-59745-157-4_5
10.1016/S0076-6879(08)03612-4
10.1038/sj.onc.1209106
10.1016/j.bbapap.2011.06.019
10.1038/cddis.2009.17
10.4161/cc.7.20.6881
10.1113/jphysiol.2013.253203
10.1083/jcb.12.1.198
10.1016/S0092-8674(03)00929-2
10.1038/ncb2152
10.1016/j.bcp.2011.02.015
10.1016/S2213-2600(13)70183-8
10.1038/ncb2849
10.1038/cr.2013.159
10.1111/j.1432-1033.1993.tb18013.x
10.4161/auto.7.1.13697
10.1074/jbc.C100319200
10.1073/pnas.1302455110
10.1089/ars.2013.5359
10.1038/nrm2529
10.1038/nrd3802
10.1073/pnas.73.10.3433
10.1042/bj3510545
10.1128/MCB.01075-12
10.1016/j.molcel.2014.01.016
10.1038/cr.2013.166
10.4161/auto.26863
10.1038/cr.2013.169
10.1016/0378-4274(85)90015-3
10.1042/bj3340261
10.1074/jbc.C200171200
10.1016/j.abb.2011.10.015
10.1016/j.bbrc.2004.11.015
10.1007/BF00583532
10.1038/sj.emboj.7601623
10.1007/s10863-011-9381-4
10.1042/BST0370232
10.1007/s00726-009-0377-x
10.1083/jcb.200803137
10.1016/j.molcel.2006.12.009
10.1083/jcb.78.1.152
10.1016/j.molmed.2012.05.007
10.1016/j.cell.2013.08.044
10.1038/cr.2013.161
10.1016/j.freeradbiomed.2012.07.011
10.3390/ijms14036306
10.1016/j.molcel.2008.03.003
10.1074/jbc.273.7.3963
10.1074/jbc.273.23.14484
10.1083/jcb.201306041
10.1126/science.1196371
10.1124/mol.111.071761
10.1016/j.molcel.2006.03.029
10.1016/j.cell.2005.07.002
10.1152/ajpendo.90645.2008
10.1016/j.cmet.2012.03.015
10.1016/j.cell.2012.12.016
10.1073/pnas.0506925102
10.1083/jcb.113.6.1305
10.1126/science.1157535
10.1038/nature09076
10.1016/j.cellsig.2012.09.020
10.1074/jbc.M603536200
10.1038/ncb1753
10.1074/jbc.274.17.11647
10.1073/pnas.0903316106
10.1098/rsob.130185
10.1083/jcb.201307084
10.1074/jbc.M112.365767
10.1139/y02-078
10.1152/ajpendo.00745.2009
10.1083/jcb.200907014
10.1128/MCB.26.1.63-76.2006
10.1038/cdd.2013.187
10.1111/j.1432-1033.1991.tb15963.x
10.1083/jcb.152.3.519
10.1016/j.cellsig.2013.02.012
10.1042/bj20021266
10.1074/jbc.M306337200
10.1038/nrm2249
10.1016/0014-4827(77)90402-5
10.1016/S1097-2765(00)00028-9
10.1016/j.cell.2012.07.032
10.1042/bj2840633
10.1091/mbc.E08-12-1249
10.1074/jbc.274.2.1092
10.4161/auto.5.1.7207
10.1126/science.1715094
10.1016/j.cmet.2011.06.008
10.1074/jbc.M605488200
10.1016/j.cell.2013.11.049
10.1074/jbc.275.2.992
10.1126/scisignal.2003019
10.1016/j.cell.2012.03.017
10.1016/j.cub.2011.02.007
10.1016/j.cell.2012.02.044
10.1172/JCI1326
10.1074/jbc.M003633200
10.1038/onc.2012.465
10.1074/jbc.M113.528505
10.1016/j.molcel.2011.06.038
10.1111/febs.12486
10.1074/jbc.M205028200
10.1016/j.cell.2007.06.009
10.1016/0014-5793(87)80271-5
10.1016/j.cmet.2007.11.001
10.1111/j.1432-1033.1993.tb18053.x
10.1126/science.1225967
10.1146/annurev-biochem-052709-094552
10.1074/jbc.270.5.2320
10.1002/(SICI)1097-4644(20000501)77:2<234::AID-JCB7>3.0.CO;2-I
10.4161/auto.26864
10.1038/nature07813
10.1038/emboj.2012.32
10.1038/nrm2245
10.1056/NEJMra1205406
10.1038/nrm3735
10.1038/nrm3696
10.1038/ncomms4207
10.1111/jcmm.12257
10.1016/S0021-9258(18)49257-5
10.1016/S0021-9258(19)77670-4
10.1038/ncomms1144
10.4161/auto.19496
10.1152/ajpendo.2000.279.4.E715
10.1016/S0026-895X(25)11054-7
10.1016/S0021-9258(18)63163-1
10.1152/ajpcell.1998.274.1.C206
10.1152/physrev.1989.69.2.315
10.1152/physrev.1983.63.2.547
10.1016/S0021-9258(18)42627-0
10.1074/jbc.M106703200
10.1074/jbc.271.28.16668
10.1093/jn/133.6.2052S
10.1002/bies.201300064
10.1042/0264-6021:3510545
10.1016/S0021-9258(19)40142-7
10.1016/j.devcel.2014.03.017
10.1126/scisignal.2000911
ContentType Journal Article
Copyright The Author(s) 2014
Copyright Springer Nature B.V. Oct 2015
Copyright_xml – notice: The Author(s) 2014
– notice: Copyright Springer Nature B.V. Oct 2015
DBID FBQ
C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7TK
7X7
7XB
88E
8AO
8FE
8FG
8FH
8FI
8FJ
8FK
ABJCF
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
CCPQU
D1I
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
KB.
LK8
M0S
M1P
M7P
PDBOC
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
7X8
7U5
8FD
L7M
7S9
L.6
5PM
DOI 10.1007/s00726-014-1765-4
DatabaseName AGRIS
Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Neurosciences Abstracts
ProQuest Health & Medical Collection (NC LIVE)
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Materials Science & Engineering Collection
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Database
ProQuest Central
Technology Collection
Natural Science Collection
ProQuest One Community College
ProQuest Materials Science Collection
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Materials Science Database (NC LIVE)
ProQuest Biological Science Collection
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
Materials Science Collection
ProQuest Central Premium
ProQuest One Academic
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
Solid State and Superconductivity Abstracts
Technology Research Database
Advanced Technologies Database with Aerospace
AGRICOLA
AGRICOLA - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest Central Student
Technology Collection
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
Materials Science Database
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Materials Science Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Materials Science & Engineering Collection
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
Technology Research Database
Advanced Technologies Database with Aerospace
Solid State and Superconductivity Abstracts
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList ProQuest Central Student
Technology Research Database
MEDLINE

AGRICOLA

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
– sequence: 5
  dbid: FBQ
  name: AGRIS
  url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN
  sourceTypes: Publisher
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
EISSN 1438-2199
EndPage 2063
ExternalDocumentID PMC4580722
3816028191
24880909
10_1007_s00726_014_1765_4
US201600012035
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GroupedDBID ---
-4W
-56
-5G
-BR
-EM
-Y2
-~C
.86
.VR
06C
06D
0R~
0VY
1SB
2.D
203
23M
28-
29~
2J2
2JN
2JY
2KG
2KM
2LR
2P1
2VQ
2~H
30V
3SX
3V.
4.4
406
408
409
40D
40E
53G
5GY
5QI
5VS
67N
67Z
6NX
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
8TC
8UJ
95-
95.
95~
96X
AAAVM
AABHQ
AABYN
AAFGU
AAHNG
AAIAL
AAJKR
AANXM
AANZL
AARHV
AARTL
AATNV
AATVU
AAUYE
AAWCG
AAYFA
AAYIU
AAYQN
AAYTO
ABBBX
ABBXA
ABDZT
ABECU
ABELW
ABFGW
ABFTV
ABHLI
ABHQN
ABJCF
ABJNI
ABJOX
ABKAS
ABKCH
ABKTR
ABMNI
ABMQK
ABNWP
ABPLI
ABPTK
ABQBU
ABSXP
ABTEG
ABTHY
ABTKH
ABTMW
ABULA
ABUWG
ABWNU
ABXPI
ACBMV
ACBRV
ACBXY
ACBYP
ACGFS
ACHSB
ACHXU
ACIGE
ACIPQ
ACIWK
ACKNC
ACMDZ
ACMLO
ACOKC
ACOMO
ACPRK
ACSNA
ACTTH
ACVWB
ACWMK
ADBBV
ADHHG
ADHIR
ADIMF
ADINQ
ADKNI
ADKPE
ADMDM
ADOAH
ADOXG
ADRFC
ADTPH
ADURQ
ADYFF
ADYPR
ADZKW
AEBTG
AEEQQ
AEFIE
AEFTE
AEGAL
AEGNC
AEJHL
AEJRE
AEKMD
AENEX
AEOHA
AEPYU
AESKC
AESTI
AETLH
AEVLU
AEVTX
AEXYK
AFEXP
AFGCZ
AFKRA
AFLOW
AFNRJ
AFQWF
AFWTZ
AFZKB
AGAYW
AGDGC
AGGBP
AGGDS
AGJBK
AGMZJ
AGQMX
AGWIL
AGWZB
AGYKE
AHAVH
AHBYD
AHKAY
AHMBA
AHSBF
AHYZX
AIAKS
AIIXL
AILAN
AIMYW
AITGF
AJBLW
AJDOV
AJRNO
AJZVZ
AKMHD
AKQUC
ALMA_UNASSIGNED_HOLDINGS
ALWAN
AMKLP
AMXSW
AMYLF
AMYQR
AOCGG
AOSHJ
ARMRJ
ASPBG
AVWKF
AXYYD
AZFZN
B-.
BA0
BBNVY
BBWZM
BDATZ
BENPR
BGLVJ
BGNMA
BHPHI
BPHCQ
BVXVI
CAG
CCPQU
COF
CS3
CSCUP
D1I
DDRTE
DL5
DNIVK
DPUIP
EBD
EBLON
EBS
EIOEI
EJD
EMOBN
EN4
EPAXT
ESBYG
F5P
FBQ
FEDTE
FERAY
FFXSO
FIGPU
FINBP
FNLPD
FRRFC
FSGXE
FWDCC
FYUFA
G-Y
G-Z
GGCAI
GGRSB
GJIRD
GNWQR
GQ6
GQ7
GQ8
GXS
HCIFZ
HF~
HG5
HG6
HMCUK
HMJXF
HQYDN
HRMNR
HVGLF
HZ~
I09
IHE
IJ-
IKXTQ
IWAJR
IXC
IXD
IXE
IZIGR
IZQ
I~X
I~Z
J-C
J0Z
JBSCW
JCJTX
JZLTJ
KB.
KDC
KOV
KOW
KPH
LAS
LK8
LLZTM
M1P
M4Y
M7P
MA-
N2Q
NB0
NDZJH
NPVJJ
NQJWS
NU0
O9-
O93
O9G
O9I
O9J
OAM
OVD
P19
P2P
PDBOC
PF0
PQQKQ
PROAC
PSQYO
PT4
PT5
QOK
QOR
QOS
R4E
R89
R9I
RHV
RIG
RNI
RNS
ROL
RPX
RRX
RSV
RZK
S16
S1Z
S26
S27
S28
S3A
S3B
SAP
SBL
SBY
SCLPG
SDH
SDM
SHX
SISQX
SJYHP
SNE
SNPRN
SNX
SOHCF
SOJ
SPISZ
SRMVM
SSLCW
SSXJD
STPWE
SV3
SZN
T13
T16
TEORI
TSG
TSK
TSV
TUC
U2A
U9L
UG4
UKHRP
UNUBA
UOJIU
UTJUX
UZXMN
VC2
VFIZW
W23
W48
W4F
WJK
WK6
WK8
YLTOR
Z45
Z7U
Z7V
Z7W
Z7X
Z81
Z82
Z83
Z87
Z8O
Z8P
Z8Q
Z8U
Z8V
Z8W
Z91
ZMTXR
ZOVNA
~EX
AAHBH
AAJSJ
AAKKN
AAYZH
ABAKF
ABEEZ
ABMOR
ABQSL
ACACY
ACULB
ACZOJ
AEFQL
AFBBN
AFGXO
AGQEE
AGRTI
ALIPV
C24
C6C
GROUPED_DOAJ
H13
AASML
AAYXX
ABDBE
ABFSG
ACSTC
ADHKG
AEZWR
AFHIU
AGQPQ
AHPBZ
AHWEU
AIXLP
AYFIA
CITATION
PHGZM
PHGZT
PJZUB
PPXIY
PQGLB
CGR
CUY
CVF
ECM
EIF
NPM
7TK
7XB
8FK
AZQEC
DWQXO
GNUQQ
K9.
PKEHL
PQEST
PQUKI
PRINS
7X8
7U5
8FD
L7M
7S9
L.6
5PM
ID FETCH-LOGICAL-c659t-4c1ed2723d1c236e1be5fb3a9b87df50d2c7e866b57125a068754d83dd8df00f3
IEDL.DBID 7X7
ISSN 0939-4451
1438-2199
IngestDate Thu Aug 21 18:13:49 EDT 2025
Thu Jul 10 22:00:22 EDT 2025
Mon Jul 21 10:17:36 EDT 2025
Fri Jul 11 10:43:39 EDT 2025
Fri Jul 25 11:06:20 EDT 2025
Thu Apr 03 07:07:35 EDT 2025
Tue Aug 05 12:05:52 EDT 2025
Thu Apr 24 22:52:20 EDT 2025
Fri Feb 21 02:37:15 EST 2025
Wed Dec 27 19:17:42 EST 2023
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 10
Keywords Lysosomes
Mitochondria
Rapamycin
Leucine
Glutamine
Language English
License Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c659t-4c1ed2723d1c236e1be5fb3a9b87df50d2c7e866b57125a068754d83dd8df00f3
Notes http://dx.doi.org/10.1007/s00726-014-1765-4
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
OpenAccessLink https://link.springer.com/10.1007/s00726-014-1765-4
PMID 24880909
PQID 1715853213
PQPubID 1456339
PageCount 27
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_4580722
proquest_miscellaneous_2000025486
proquest_miscellaneous_1762075726
proquest_miscellaneous_1716935872
proquest_journals_1715853213
pubmed_primary_24880909
crossref_citationtrail_10_1007_s00726_014_1765_4
crossref_primary_10_1007_s00726_014_1765_4
springer_journals_10_1007_s00726_014_1765_4
fao_agris_US201600012035
PublicationCentury 2000
PublicationDate 2015-10-01
PublicationDateYYYYMMDD 2015-10-01
PublicationDate_xml – month: 10
  year: 2015
  text: 2015-10-01
  day: 01
PublicationDecade 2010
PublicationPlace Vienna
PublicationPlace_xml – name: Vienna
– name: Austria
PublicationSubtitle The Forum for Amino Acid, Peptide and Protein Research
PublicationTitle Amino acids
PublicationTitleAbbrev Amino Acids
PublicationTitleAlternate Amino Acids
PublicationYear 2015
Publisher Springer Vienna
Springer Nature B.V
Publisher_xml – name: Springer Vienna
– name: Springer Nature B.V
References Holleman (CR90) 1904; 23
Jiang, Mizushima (CR102) 2014; 24
Wirth, Joachim, Tooze (CR264) 2013; 23
Avruch, Long, Ortiz-Vega, Rapley, Papageorgiou, Dai (CR9) 2009; 296
Groenewoud, Zwartkruis (CR71) 2013; 3
Ishida, Nayak, Mindell, Grabe (CR98) 2013; 141
Liang, Shao, Xu, Hennessy, Ding, Larrea, Kondo, Dumont, Gutterman, Walker, Slingerland, Mills (CR146) 2007; 9
Polson, de, Rigden DJ, Reedijk, Urbe, Clague, Tooze (CR198) 2010; 6
Meijer, Codogno (CR170) 2011; 21
Hundal, Taylor (CR94) 2009; 296
Lang, Stehle, Häussinger (CR134) 1989; 413
Scherz-Shouval, Elazar (CR214) 2011; 36
Li, Allen, Kwagh, Doliba, Qin, Najafi, Collins, Matschinsky, Stanley, Smith (CR141) 2006; 281
Menon, Dibble, Talbott, Hoxhaj, Valvezan, Takahashi, Cantley, Manning (CR174) 2014; 156
Stoll, Gerok, Lang, Häussinger (CR239) 1992; 287
Holen, Gordon, Seglen (CR89) 1993; 215
Wauson, Zaganjor, Lee, Guerra, Ghosh, Bookout, Chambers, Jivan, McGlynn, Hutchison, Deberardinis, Cobb (CR259) 2012; 47
Settembre, Di Malta, Polito, Garcia, Vetrini, Erdin, Erdin, Huynh, Medina, Colella, Sardiello, Rubinsztein, Ballabio (CR226) 2011; 332
Jung, Seo, Otto, Kim (CR106) 2011; 7
Mizushima, Komatsu (CR176) 2011; 147
Han, Jeong, Park, Kim, Kwon, Kim, Ha, Ryu, Kim (CR78) 2012; 149
Dong, Qiu, Garcia-Barrio, Anderson, Hinnebusch (CR47) 2000; 6
Eskelinen, Prescott, Cooper, Brachmann, Wang, Tang, Backer, Lucocq (CR59) 2002; 3
Duran, Oppliger, Robitaille, Heiserich, Skendaj, Gottlieb, Hall (CR52) 2012; 47
Fox, Kimball, Jefferson, Lynch (CR66) 1998; 274
Yuan, Russell, Guan (CR275) 2013; 9
Gwinn, Shackelford, Egan, Mihaylova, Mery, Vasquez, Turk, Shaw (CR73) 2008; 30
Meijer, Codogno (CR169) 2009; 46
Arico, Petiot, Bauvy, Dubbelhuis, Meijer, Codogno, Ogier-Denis (CR6) 2001; 276
Hoffmann, Simonsen (CR87) 1989; 69
Christie, Hajduch, Hundal, Proud, Taylor (CR36) 2002; 277
Sun, Chen (CR240) 2008; 7
Oshiro, Rapley, Avruch (CR190) 2013; 289
Hallbrucker, vom Dahl, Lang, Häussinger (CR76) 1991; 197
Kadowaki, Kanazawa (CR107) 2003; 133
Katz, Golden, Wals (CR109) 1976; 73
Zhou, Farah, Sinha, Wu, Singh, Bay, Yang, Yen (CR277) 2014; 9
Duran, Hall (CR50) 2012; 11
Ashford, Porter (CR7) 1962; 12
Jarzyna, Lenarcik, Bryla (CR101) 1997; 35
Simonsen, Tooze (CR234) 2009; 186
Holen, Gordon, Seglen (CR88) 1992; 284
Ao, Zou, Wu (CR5) 2014; 21
B’chir, Maurin, Carraro, Averous, Jousse, Muranishi, Parry, Stepien, Fafournoux, Bruhat (CR16) 2013; 41
Klionsky, Codogno (CR122) 2013; 5
Findlay, Yan, Procter, Mieulet, Lamb (CR65) 2007; 403
Long, Ortiz-Vega, Lin, Avruch (CR148) 2005; 280
Tallóczy, Jiang, Virgin, Leib, Scheuner, Kaufman, Eskelinen, Levine (CR242) 2002; 99
Lorin, Tol, Bauvy, Strijland, Pous, Verhoeven, Codogno, Meijer (CR150) 2013; 9
Mavrakis, Lippincott-Schwartz, Stratakis, Bossis (CR164) 2006; 15
Scherz-Shouval, Shvets, Fass, Shorer, Gil, Elazar (CR215) 2007; 26
Rao, Klein, Bonar, Zielonka, Mizuno, Dickey, Keller, Joseph, Kalyanaraman, Shacter (CR203) 2010; 285
Krause, Bertrand, Hue (CR128) 2002; 269
Seglen, Bohley (CR222) 1992; 48
van Sluijters, Dubbelhuis, Blommaart, Meijer (CR255) 2000; 351
Son, Lyssiotis, Ying, Wang, Hua, Ligorio, Perera, Ferrone, Mullarky, Shyh-Chang, Kang, Fleming, Bardeesy, Asara, Haigis, DePinho, Cantley, Kimmelman (CR236) 2013; 496
Stephan, Yeh, Ramachandran, Deminoff, Herman (CR238) 2009; 106
Andrae, Singh, Ziegler-Skylakakis (CR3) 1985; 28
Li, Zhu, Li, Assa, Jundoria, Xu, Fan, Eissa, Tracey, Sama, Wang (CR142) 2011; 81
Seglen, Gordon, Poli (CR224) 1980; 630
Krause, Bertrand, Maisin, Rosa, Hue (CR129) 2002; 269
Mariño, Niso-Santano, Baehrecke, Kroemer (CR159) 2014; 15
Russell, Yuan, Guan (CR209) 2014; 24
Ge, Melville, Zhang, Schekman (CR68) 2013; 2
Canto, Gerhart-Hines, Feige, Lagouge, Noriega, Milne, Elliott, Puigserver, Auwerx (CR29) 2009; 458
Kim, Kim, Maag, Maxwell, Resnick, Juluri, Chakraborty, Koldobskiy, Cha, Barrow, Snowman, Snyder (CR115) 2011; 13
Cuervo, Wong (CR41) 2014; 24
Feng, He, Yao, Klionsky (CR63) 2014; 24
Farrell, Rusten, Stenmark (CR62) 2013; 280
Pfeifer (CR196) 1978; 78
Ruderman, Xu, Nelson, Cacicedo, Saha, Lan, Ido (CR207) 2010; 298
Natarajan, Meyer, Jackson, Slade, Roberts, Hinnebusch, Marton (CR185) 2001; 21
Yang, Sudderth, Dang, Bachoo, McDonald, Deberardinis (CR271) 2009; 69
Matsui, Takagi, Qu, Abdellatif, Sakoda, Asano, Levine, Sadoshima (CR163) 2007; 100
Sancak, Peterson, Shaul, Lindquist, Thoreen, Bar-Peled, Sabatini (CR211) 2008; 320
Lorin, Hamai, Mehrpour, Codogno (CR149) 2013; 23
Ktistakis, Andrews, Long (CR131) 2011; 7
Blommaart, Krause, Schellens, Vreeling-Sindelarova, Meijer (CR25) 1997; 243
Dann, Thomas (CR43) 2006; 580
Harder, Bunkenborg, Andersen (CR80) 2014; 10
Hermans, Casaer, Clerckx, Güiza, Vanhullebusch, Derde, Meersseman, Derese, Mesotten, Wouters, Van Cromphaut, Debaveye, Gosselink, Gunst, Wilmer, Van den Berghe, Vanhorebeek (CR85) 2013; 1
Bolster, Crozier, Kimball, Jefferson (CR27) 2002; 277
Pfisterer, Mauthe, Codogno, Proikas-Cezanne (CR197) 2011; 80
Iiboshi, Papst, Kawasome, Hosoi, Abraham, Houghton, Terada (CR95) 1999; 274
Fang, Vilella-Bach, Bachmann, Flanigan, Chen (CR61) 2001; 294
Yoon, Du, Backer, Frohman, Chen (CR273) 2011; 195
Sancak, Bar-Peled, Zoncu, Markhard, Nada, Sabatini (CR212) 2010; 141
Roccio, Bos, Zwartkruis (CR205) 2006; 25
Laplante, Sabatini (CR135) 2012; 149
Morales, Pedrozo, Lavandero, Hill (CR178) 2014; 20
Tsun, Bar-Peled, Chantranupong, Zoncu, Wang, Kim, Spooner, Sabatini (CR250) 2013; 52
Puri, Renna, Bento, Moreau, Rubinsztein (CR199) 2013; 154
Lynch, Fox, Vary, Jefferson, Kimball (CR153) 2000; 77
Kim, Guan (CR112) 2011; 80
Hoyer-Hansen, Bastholm, Szyniarowski, Campanella, Szabadkai, Farkas, Bianchi, Fehrenbacher, Elling, Rizzuto, Mathiasen, Jaattela (CR92) 2007; 25
Petiot, Ogier-Denis, Blommaart, Meijer, Codogno (CR193) 2000; 275
CR124
Heitman, Movva, Hall (CR84) 1991; 253
Betz, Stracka, Prescianotto-Baschong, Frieden, Demaurex, Hall (CR19) 2013; 110
Rubinsztein, Codogno, Levine (CR206) 2012; 11
Albracht, Meijer, Rydstrom (CR2) 2011; 43
Klionsky (CR121) 2007; 8
Rahman, Mofarrahi, Kristof, Nkengfac, Harel, Hussain (CR201) 2014; 20
Choi, Ryter, Levine (CR35) 2013; 368
Kimball, Siegfried, Jefferson (CR119) 2004; 279
Lamb, Yoshimori, Tooze (CR133) 2013; 14
Thoreen, Kang, Chang, Liu, Zhang, Gao, Reichling, Sim, Sabatini, Gray (CR247) 2009; 284
Hara, Yonezawa, Weng, Kozlowski, Belham, Avruch (CR79) 1998; 273
Pfeifer (CR195) 1977; 36
Weidberg, Shvets, Elazar (CR261) 2011; 80
Kanazawa, Taneike, Akaishi, Yoshizawa, Furuya, Fujimura, Kadowaki (CR108) 2004; 279
Hinnebusch (CR86) 1997; 272
Li, Ishdorj, Gibson (CR143) 2012; 53
Wei, Pattingre, Sinha, Bassik, Levine (CR260) 2008; 30
Seglen, Gordon (CR223) 1982; 79
Häussinger, Reinehr, Schliess (CR83) 2006; 187
Mortimore, Mondon (CR180) 1970; 245
Inoki, Zhu, Guan (CR96) 2003; 115
Manning, Cantley (CR157) 2007; 129
Kim, Buel, Blenis (CR117) 2013; 35
Dubbelhuis, Meijer (CR48) 2002; 521
Mizushima, Klionsky (CR175) 2007; 27
Chang, Juhasz, Goraksha-Hicks, Arsham, Mallin, Muller, Neufeld (CR33) 2009; 37
Kim, Kundu, Viollet, Guan (CR114) 2011; 13
Rigbolt, Zarei, Sprenger, Becker, Diedrich, Huang, Eiselein, Kristensen, Gretzmeier, Andersen, Zi, Dengjel (CR204) 2014; 10
Tzatsos, Kandror (CR251) 2006; 26
Egan, Shackelford, Mihaylova, Gelino, Kohnz, Mair, Vasquez, Joshi, Gwinn, Taylor, Asara, Fitzpatrick, Dillin, Viollet, Kundu, Hansen, Shaw (CR56) 2011; 331
Häussinger (CR82) 1996; 313
Yan, Mieulet, Burgess, Findlay, Sully, Procter, Goris, Janssens, Morrice, Lamb (CR270) 2010; 37
Mammucari, Milan, Romanello, Masiero, Rudolf, Del Piccolo, Burden, Di Lisi, Sandri, Zhao, Goldberg, Schiaffino, Sandri (CR156) 2007; 6
Wong, Puente, Ganley, Jiang (CR265) 2013; 9
Efeyan, Zoncu, Sabatini (CR54) 2012; 18
Sarbassov, Ali, Sengupta, Sheen, Hsu, Bagley, Markhard, Sabatini (CR213) 2006; 22
Martin, Sutherland (CR161) 2001; 240
Xu, Salloum, Medlin, Saqcena, Yellen, Perrella, Foster (CR269) 2011; 286
Jin, Mao, Jin, Tevzadze, Kauffman, Park, Bridges, Loewith, Saltiel, Klionsky, Weisman (CR103) 2014; 25
Duran, Amanchy, Linares, Joshi, Abu-Baker, Porollo, Hansen, Moscat, Diaz-Meco (CR51) 2011; 44
Fetalvero, Yu, Goetschkes, Liang, Valdez, Gould, Triantafellow, Bergling, Loureiro, Eash, Lin, Porter, Finan, Walsh, Yang, Mao, Murphy (CR64) 2013; 33
Ye, Varamini, Lamming, Sabatini, Baur (CR272) 2012; 3
Settembre, Zoncu, Medina, Vetrini, Erdin, Erdin, Huynh, Ferron, Karsenty, Vellard, Facchinetti, Sabatini, Ballabio (CR227) 2012; 31
Li, Li, Allen, Stanley, Smith (CR144) 2012; 519
Gelino, Hansen (CR69) 2012; 4
Atherton, Smith, Etheridge, Rankin, Rennie (CR8) 2010; 38
Hagiwara, Cornu, Cybulski, Polak, Betz, Trapani, Terracciano, Heim, Ruegg, Hall (CR74) 2012; 15
Fahien, Teller, Macdonald, Fahien (CR60) 1990; 37
Schu, Takegawa, Fry, Stack, Waterfield, Emr (CR219) 1993; 260
Ohsumi (CR189) 2014; 24
Blommaart, Luiken, Blommaart, van Woerkom, Meijer (CR23) 1995; 270
Wiczer, Thomas (CR262) 2012; 5
McAlpine, Williamson, Tooze, Chan (CR165) 2013; 9
Mortimore, Poso, Kadowaki, Wert (CR181) 1987; 262
Thevelein, de Winde (CR246) 1999; 33
Tardito, Chiu, Franchi-Gazzola, Dall’Asta, Comi, Bussolati (CR244) 2012; 42
Hailey, Lippincott-Schwartz (CR75) 2009; 452
Shigemitsu, Tsujishita, Hara, Nanahoshi, Avruch, Yonezawa (CR232) 1999; 274
Tan, Hagen (CR243) 2013; 25
Corradetti, Inoki, Bardeesy, DePinho, Guan (CR39) 2004; 18
Noda, Ohsumi (CR188) 1998; 273
CR42
Duran, Hall (CR49) 2012; 22
Kihara, Noda, Ishihara, Ohsumi (CR111) 2001; 152
Lee, Cao, Mostoslavsky, Lombard, Liu, Bruns, Tsokos, Alt, Finkel (CR139) 2008; 105
Blagosklonny (CR22) 2010; 1
Xu, Kwon, Cruz, Marshall, McDaniel (CR268) 2001; 50
Duran, MacKenzie, Boulahbel, Frezza, Heiserich, Tardito, Bussolati, Rocha, Hall, Gottlieb (CR53) 2013; 32
Chan, Longatti, McKnight, Tooze (CR32) 2009; 29
Bar-Peled, Schweitzer, Zoncu, Sabatini (CR14) 2012; 150
Bolisetty, Jaimes (CR26) 2013; 14
Kimball, Shantz, Horetsky, Jefferson (CR118) 1999; 274
Meley, Bauvy, Houben-Weerts, Dubbelhuis, Helmond, Codogno, Meijer (CR173) 2006; 281
Baquet, Maisin, Hue (CR12) 1991; 278
Hardie (CR81) 2007; 8
Jang, Choi, Min (CR100) 2014; 21
Mates, Segura, Martin-Rufian, Campos-Sandoval, Alonso, Marquez (CR162) 2013; 13
Cheng, Fujita, Yamamoto, Tatematsu, Kakuta, Obara, O
S Lorin (1765_CR149) 2013; 23
JS Stephan (1765_CR238) 2009; 106
C Hallbrucker (1765_CR76) 1991; 197
C Mammucari (1765_CR156) 2007; 6
A Simonsen (1765_CR234) 2009; 186
M Rahman (1765_CR201) 2014; 20
Y Sancak (1765_CR212) 2010; 141
BD Manning (1765_CR157) 2007; 129
RV Duran (1765_CR53) 2013; 32
C Settembre (1765_CR227) 2012; 31
EY Chan (1765_CR32) 2009; 29
SR Kimball (1765_CR118) 1999; 274
N Jaber (1765_CR99) 2012; 109
E Kim (1765_CR113) 2008; 10
L Li (1765_CR143) 2012; 53
U Krause (1765_CR128) 2002; 269
EF Blommaart (1765_CR23) 1995; 270
J Dong (1765_CR47) 2000; 6
CY Tan (1765_CR243) 2013; 25
SP Albracht (1765_CR2) 2011; 43
A Hagiwara (1765_CR74) 2012; 15
J Liang (1765_CR146) 2007; 9
X Wang (1765_CR256) 1998; 334
G Xu (1765_CR267) 1998; 273
PM Wong (1765_CR265) 2013; 9
SG Dann (1765_CR43) 2006; 580
RL Deter (1765_CR46) 1967; 35
DA Sluijters van (1765_CR255) 2000; 351
SG Kim (1765_CR117) 2013; 35
RC Russell (1765_CR209) 2014; 24
O Farrell (1765_CR62) 2013; 280
RV Duran (1765_CR49) 2012; 22
X Long (1765_CR148) 2005; 280
L Bar-Peled (1765_CR15) 2013; 340
JM Mates (1765_CR162) 2013; 13
W B’chir (1765_CR16) 2013; 41
DR Bolster (1765_CR27) 2002; 277
C Demetriades (1765_CR44) 2014; 156
L Ge (1765_CR68) 2013; 2
T Nakajo (1765_CR184) 2005; 326
J Kim (1765_CR116) 2013; 152
JJ Luiken (1765_CR152) 1996; 235
GE Mortimore (1765_CR180) 1970; 245
CH Jung (1765_CR105) 2009; 20
Y Wei (1765_CR260) 2008; 30
P Nicklin (1765_CR186) 2009; 136
F Xiao (1765_CR266) 2011; 60
J Zhou (1765_CR277) 2014; 9
C Canto (1765_CR29) 2009; 458
Z Kovacevic (1765_CR125) 1983; 63
KM Fetalvero (1765_CR64) 2013; 33
Y Matsui (1765_CR163) 2007; 100
JM Han (1765_CR78) 2012; 149
AJ Meijer (1765_CR167) 2009; 5
EF Blommaart (1765_CR24) 1997; 29
M Mavrakis (1765_CR164) 2006; 15
SM Schieke (1765_CR216) 2006; 281
L Yu (1765_CR274) 2010; 465
M Laplante (1765_CR135) 2012; 149
PB Dennis (1765_CR45) 2001; 294
A Ciechanover (1765_CR37) 2012; 10
F Adhami (1765_CR1) 2006; 169
EM Smith (1765_CR235) 2005; 280
RJ Marc (1765_CR158) 2009; 37
D Meley (1765_CR173) 2006; 281
RE Stanley (1765_CR237) 2014; 24
L Bar-Peled (1765_CR14) 2012; 150
A Duran (1765_CR51) 2011; 44
T Nobukuni (1765_CR187) 2005; 102
KO Schink (1765_CR217) 2013; 35
S Pattingre (1765_CR192) 2005; 122
EM Wauson (1765_CR259) 2012; 47
CH Jung (1765_CR106) 2011; 7
T Kanazawa (1765_CR108) 2004; 279
U Andrae (1765_CR3) 1985; 28
A Tassa (1765_CR245) 2003; 376
PO Seglen (1765_CR223) 1982; 79
CC Thoreen (1765_CR247) 2009; 284
U Pfeifer (1765_CR196) 1978; 78
SH Um (1765_CR253) 2004; 431
N Kimura (1765_CR120) 2003; 8
Y Sancak (1765_CR211) 2008; 320
S Tardito (1765_CR244) 2012; 42
C Betz (1765_CR18) 2013; 203
HM Shen (1765_CR230) 2014; 39
AM Cuervo (1765_CR41) 2014; 24
GE Mortimore (1765_CR182) 1988; 263
AJ Meijer (1765_CR169) 2009; 46
DD Sarbassov (1765_CR213) 2006; 22
SG Pfisterer (1765_CR197) 2011; 80
R Jarzyna (1765_CR101) 1997; 35
S Kim (1765_CR115) 2011; 13
Y Ishida (1765_CR98) 2013; 141
NT Ktistakis (1765_CR132) 2012; 40
MAF Holleman (1765_CR90) 1904; 23
N Mizushima (1765_CR176) 2011; 147
Y Ohsumi (1765_CR189) 2014; 24
AJ Meijer (1765_CR172) 1993; 215
A Efeyan (1765_CR54) 2012; 18
AJ Meijer (1765_CR166) 2008; 445
R Barazzoni (1765_CR13) 2012; 303
DG Hardie (1765_CR81) 2007; 8
J Katz (1765_CR109) 1976; 73
HE Polson (1765_CR198) 2010; 6
TP Ashford (1765_CR7) 1962; 12
NB Ruderman (1765_CR207) 2010; 298
VJ Lavallard (1765_CR137) 2012; 66
CR Morales (1765_CR178) 2014; 20
C Puri (1765_CR199) 2013; 154
AB Angcajas (1765_CR4) 2014; 446
1765_CR91
PM Martin (1765_CR161) 2001; 240
J Avruch (1765_CR9) 2009; 296
DJ Klionsky (1765_CR121) 2007; 8
KE Vos van der (1765_CR254) 2012; 14
RJ Mailloux (1765_CR155) 2007; 2
J Kim (1765_CR114) 2011; 13
G Mariño (1765_CR159) 2014; 15
W Quan (1765_CR200) 2013; 28
SR Kimball (1765_CR119) 2004; 279
K Inoki (1765_CR97) 2012; 52
CJ Lynch (1765_CR154) 2003; 285
SC Schriever (1765_CR218) 2013; 24
U Pfeifer (1765_CR195) 1977; 36
A Sener (1765_CR225) 1980; 288
M Wirth (1765_CR264) 2013; 23
RV Duran (1765_CR50) 2012; 11
EL Eskelinen (1765_CR59) 2002; 3
M Kadowaki (1765_CR107) 2003; 133
JM Thevelein (1765_CR246) 1999; 33
C Yang (1765_CR271) 2009; 69
S Bolisetty (1765_CR26) 2013; 14
G Bjorkoy (1765_CR21) 2009; 452
AJ Meijer (1765_CR168) 2008; 10
M Li (1765_CR144) 2012; 519
G Kroemer (1765_CR130) 2008; 9
N Mizushima (1765_CR175) 2007; 27
LA Fahien (1765_CR60) 1990; 37
DJ Wilkinson (1765_CR263) 2013; 591
YH Jang (1765_CR100) 2014; 21
DJ Klionsky (1765_CR123) 2010; 6
AP Lieberman (1765_CR147) 2012; 8
X Ao (1765_CR5) 2014; 21
MH Sahani (1765_CR210) 2014; 10
K Shigemitsu (1765_CR232) 1999; 274
CS Petit (1765_CR194) 2013; 202
BM Wiczer (1765_CR262) 2012; 5
PF Dubbelhuis (1765_CR48) 2002; 521
DW Hailey (1765_CR75) 2009; 452
JJ Luiken (1765_CR151) 1994; 22
T Eisenberg (1765_CR57) 2014; 19
1765_CR42
LM Harder (1765_CR80) 2014; 10
MS Yoon (1765_CR273) 2011; 195
GE Mortimore (1765_CR181) 1987; 262
T Naito (1765_CR183) 2013; 288
L Li (1765_CR145) 2013; 25
R Zoncu (1765_CR278) 2011; 334
G Xu (1765_CR268) 2001; 50
M Roccio (1765_CR205) 2006; 25
S Lorin (1765_CR150) 2013; 9
A Tzatsos (1765_CR251) 2006; 26
PO Seglen (1765_CR221) 1977; 107
MJ Groenewoud (1765_CR71) 2013; 3
G Ghislat (1765_CR70) 2012; 287
J Heitman (1765_CR84) 1991; 253
R Scherz-Shouval (1765_CR214) 2011; 36
I Holen (1765_CR88) 1992; 284
AL Kovacs (1765_CR126) 1982; 137
S Menon (1765_CR174) 2014; 156
G Juhasz (1765_CR104) 2012; 8
EF Blommaart (1765_CR25) 1997; 243
J Zhang (1765_CR276) 2013; 15
DJ Klionsky (1765_CR122) 2013; 5
PO Seglen (1765_CR222) 1992; 48
K Shigemitsu (1765_CR233) 1999; 447
1765_CR58
T Noda (1765_CR188) 1998; 273
A Ramanathan (1765_CR202) 2009; 106
YY Chang (1765_CR33) 2009; 37
1765_CR55
NT Ktistakis (1765_CR131) 2011; 7
XM Leverve (1765_CR140) 1987; 219
RV Duran (1765_CR52) 2012; 47
G Hermans (1765_CR85) 2013; 1
S Arico (1765_CR6) 2001; 276
B Moazed (1765_CR177) 2002; 80
KT Rigbolt (1765_CR204) 2014; 10
F Tremblay (1765_CR249) 2001; 276
XJ Wang (1765_CR258) 2013; 9
Y Fang (1765_CR61) 2001; 294
D Häussinger (1765_CR82) 1996; 313
Y Sun (1765_CR240) 2008; 7
HS Hundal (1765_CR94) 2009; 296
ZY Tsun (1765_CR250) 2013; 52
G Mariño (1765_CR160) 2014; 53
T Toyoda (1765_CR248) 2004; 287
J Son (1765_CR236) 2013; 496
W Li (1765_CR142) 2011; 81
J Kim (1765_CR112) 2011; 80
AJ Meijer (1765_CR171) 1992; 267
RC Russell (1765_CR208) 2013; 15
AK Larsen (1765_CR136) 2002; 277
Y Feng (1765_CR63) 2014; 24
HX Yuan (1765_CR275) 2013; 9
PJ Atherton (1765_CR8) 2010; 38
M Hamasaki (1765_CR77) 2013; 495
P Jiang (1765_CR102) 2014; 24
OJ Shah (1765_CR228) 2000; 279
GR Christie (1765_CR36) 2002; 277
IG Ganley (1765_CR67) 2009; 284
A Baquet (1765_CR11) 1990; 265
A Baquet (1765_CR12) 1991; 278
MN Corradetti (1765_CR39) 2004; 18
VA Rao (1765_CR203) 2010; 285
CJ Lynch (1765_CR153) 2000; 77
AJ Meijer (1765_CR170) 2011; 21
N Oshiro (1765_CR190) 2013; 289
F Lang (1765_CR134) 1989; 413
K Suzuki (1765_CR241) 2001; 20
HL Fox (1765_CR66) 1998; 274
B Stoll (1765_CR239) 1992; 287
L Yan (1765_CR270) 2010; 37
C Betz (1765_CR19) 2013; 110
F McAlpine (1765_CR165) 2013; 9
DF Egan (1765_CR56) 2011; 331
U Krause (1765_CR129) 2002; 269
RC Wang (1765_CR257) 2012; 338
LH Caro (1765_CR30) 1989; 181
H Hoyvik (1765_CR93) 1991; 113
DM Gwinn (1765_CR73) 2008; 30
IH Lee (1765_CR139) 2008; 105
U Krause (1765_CR127) 1996; 271
A Petiot (1765_CR193) 2000; 275
L Xu (1765_CR269) 2011; 286
D Bridges (1765_CR28) 2012; 23
J Cheng (1765_CR34) 2014; 5
EL Axe (1765_CR10) 2008; 182
AM Choi (1765_CR35) 2013; 368
K Inoki (1765_CR96) 2003; 115
N Jin (1765_CR103) 2014; 25
IH Lee (1765_CR138) 2009; 284
D Benjamin (1765_CR17) 2013; 15
GM Findlay (1765_CR65) 2007; 403
CM Schworer (1765_CR220) 1979; 76
EK Hoffmann (1765_CR87) 1989; 69
H Weidberg (1765_CR261) 2011; 80
M Cornu (1765_CR38) 2013; 23
I Holen (1765_CR89) 1993; 215
R Scherz-Shouval (1765_CR215) 2007; 26
AG Hinnebusch (1765_CR86) 1997; 272
L Ye (1765_CR272) 2012; 3
C Li (1765_CR141) 2006; 281
P Gulati (1765_CR72) 2008; 7
MV Blagosklonny (1765_CR22) 2010; 1
A Csibi (1765_CR40) 2013; 153
A Beugnet (1765_CR20) 2003; 372
G Cavallini (1765_CR31) 2008; 1
C Settembre (1765_CR226) 2011; 332
NP Shanware (1765_CR229) 2013; 53
PO Seglen (1765_CR224) 1980; 630
PV Schu (1765_CR219) 1993; 260
K Natarajan (1765_CR185) 2001; 21
1765_CR124
ST Shibutani (1765_CR231) 2014; 24
S Kaushik (1765_CR110) 2011; 14
A Kihara (1765_CR111) 2001; 152
K Hara (1765_CR79) 1998; 273
CA Lamb (1765_CR133) 2013; 14
S Mordier (1765_CR179) 2000; 275
S Gelino (1765_CR69) 2012; 4
Y Iiboshi (1765_CR95) 1999; 274
T Ueno (1765_CR252) 2012; 1824
DC Rubinsztein (1765_CR206) 2012; 11
D Häussinger (1765_CR83) 2006; 187
Z Tallóczy (1765_CR242) 2002; 99
M Hoyer-Hansen (1765_CR92) 2007; 25
ME Patti (1765_CR191) 1998; 101
References_xml – volume: 263
  start-page: 19545
  year: 1988
  end-page: 19551
  ident: CR182
  article-title: Modulation of the amino acid control of hepatic protein degradation by caloric deprivation. Two modes of alanine co-regulation
  publication-title: J Biol Chem
– volume: 41
  start-page: 7683
  year: 2013
  end-page: 7699
  ident: CR16
  article-title: The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkt563
– volume: 37
  start-page: 111
  year: 2009
  end-page: 122
  ident: CR158
  article-title: Glutamine, arginine, and leucine signaling in the intestine
  publication-title: Amino Acids
  doi: 10.1007/s00726-008-0225-4
– volume: 28
  start-page: 6
  year: 2013
  end-page: 11
  ident: CR200
  article-title: Role of autophagy in the control of body metabolism
  publication-title: Endocrinol Metab (Seoul)
  doi: 10.3803/EnM.2013.28.1.6
– volume: 36
  start-page: 30
  year: 2011
  end-page: 38
  ident: CR214
  article-title: Regulation of autophagy by ROS: physiology and pathology
  publication-title: Trends Biochem Sci
  doi: 10.1016/j.tibs.2010.07.007
– volume: 2
  start-page: e00947
  year: 2013
  ident: CR68
  article-title: The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis
  publication-title: Elife
  doi: 10.7554/eLife.00947
– volume: 285
  start-page: 34447
  year: 2010
  end-page: 34459
  ident: CR203
  article-title: The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M110.133579
– volume: 60
  start-page: 746
  year: 2011
  end-page: 756
  ident: CR266
  article-title: Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways
  publication-title: Diabetes
  doi: 10.2337/db10-1246
– volume: 106
  start-page: 22229
  year: 2009
  end-page: 22232
  ident: CR202
  article-title: Direct control of mitochondrial function by mTOR
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0912074106
– volume: 260
  start-page: 88
  year: 1993
  end-page: 91
  ident: CR219
  article-title: Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
  publication-title: Science
  doi: 10.1126/science.8385367
– volume: 7
  start-page: 456
  year: 2008
  end-page: 465
  ident: CR72
  article-title: Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2008.03.002
– volume: 18
  start-page: 1533
  year: 2004
  end-page: 1538
  ident: CR39
  article-title: Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
  publication-title: Genes Dev
  doi: 10.1101/gad.1199104
– volume: 22
  start-page: 1207
  year: 2012
  end-page: 1209
  ident: CR49
  article-title: Leucyl-tRNA synthetase: double duty in amino acid sensing
  publication-title: Cell Res
  doi: 10.1038/cr.2012.68
– volume: 99
  start-page: 190
  year: 2002
  end-page: 195
  ident: CR242
  article-title: Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.012485299
– volume: 2
  start-page: e690
  year: 2007
  ident: CR155
  article-title: The tricarboxylic acid cycle, an ancient metabolic network with a novel twist
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0000690
– volume: 495
  start-page: 389
  year: 2013
  end-page: 393
  ident: CR77
  article-title: Autophagosomes form at ER-mitochondria contact sites
  publication-title: Nature
  doi: 10.1038/nature11910
– volume: 1
  start-page: 4
  year: 2008
  end-page: 9
  ident: CR31
  article-title: Towards an understanding of the anti-aging mechanism of caloric restriction
  publication-title: Curr Aging Sci
  doi: 10.2174/1874609810801010004
– volume: 153
  start-page: 840
  year: 2013
  end-page: 854
  ident: CR40
  article-title: The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4
  publication-title: Cell
  doi: 10.1016/j.cell.2013.04.023
– volume: 21
  start-page: 4347
  year: 2001
  end-page: 4368
  ident: CR185
  article-title: Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.21.13.4347-4368.2001
– volume: 288
  start-page: 21074
  year: 2013
  end-page: 21081
  ident: CR183
  article-title: Differential contribution of insulin and amino acids to the mTORC1-autophagy pathway in the liver and muscle
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M113.456228
– volume: 303
  start-page: E1117
  year: 2012
  end-page: E1125
  ident: CR13
  article-title: Insulin fails to enhance mTOR phosphorylation, mitochondrial protein synthesis, and ATP production in human skeletal muscle without amino acid replacement
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00067.2012
– volume: 273
  start-page: 28178
  year: 1998
  end-page: 28184
  ident: CR267
  article-title: Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling
  publication-title: J Biol Chem
  doi: 10.1074/jbc.273.43.28178
– volume: 269
  start-page: 3751
  year: 2002
  end-page: 3759
  ident: CR128
  article-title: Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes
  publication-title: Eur J Biochem
  doi: 10.1046/j.1432-1033.2002.03074.x
– volume: 332
  start-page: 1429
  year: 2011
  end-page: 1433
  ident: CR226
  article-title: TFEB links autophagy to lysosomal biogenesis
  publication-title: Science
  doi: 10.1126/science.1204592
– volume: 47
  start-page: 851
  year: 2012
  end-page: 862
  ident: CR259
  article-title: The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2012.08.001
– volume: 195
  start-page: 435
  year: 2011
  end-page: 447
  ident: CR273
  article-title: Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway
  publication-title: J Cell Biol
  doi: 10.1083/jcb.201107033
– volume: 452
  start-page: 25
  year: 2009
  end-page: 45
  ident: CR75
  article-title: Using photoactivatable proteins to monitor autophagosome lifetime
  publication-title: Methods Enzymol
  doi: 10.1016/S0076-6879(08)03603-3
– volume: 5
  start-page: 427
  year: 2013
  end-page: 433
  ident: CR122
  article-title: The mechanism and physiological function of macroautophagy
  publication-title: J Innate Immun
  doi: 10.1159/000351979
– volume: 15
  start-page: 2962
  year: 2006
  end-page: 2971
  ident: CR164
  article-title: Depletion of type IA regulatory subunit (RIalpha) of protein kinase A (PKA) in mammalian cells and tissues activates mTOR and causes autophagic deficiency
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddl239
– volume: 334
  start-page: 678
  year: 2011
  end-page: 683
  ident: CR278
  article-title: mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
  publication-title: Science
  doi: 10.1126/science.1207056
– volume: 269
  start-page: 3742
  year: 2002
  end-page: 3750
  ident: CR129
  article-title: Signalling pathways and combinatory effects of insulin and amino acids in isolated rat hepatocytes
  publication-title: Eur J Biochem
  doi: 10.1046/j.1432-1033.2002.03069.x
– volume: 8
  start-page: 719
  year: 2012
  end-page: 730
  ident: CR147
  article-title: Autophagy in lysosomal storage disorders
  publication-title: Autophagy
  doi: 10.4161/auto.19469
– volume: 274
  start-page: 1058
  year: 1999
  end-page: 1065
  ident: CR232
  article-title: Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.2.1058
– volume: 181
  start-page: 717
  year: 1989
  end-page: 720
  ident: CR30
  article-title: A combination of intracellular leucine with either glutamate or aspartate inhibits autophagic proteolysis in isolated rat hepatocytes
  publication-title: Eur J Biochem
  doi: 10.1111/j.1432-1033.1989.tb14782.x
– volume: 7
  start-page: 1212
  year: 2011
  end-page: 1221
  ident: CR106
  article-title: ULK1 inhibits the kinase activity of mTORC1 and cell proliferation
  publication-title: Autophagy
  doi: 10.4161/auto.7.10.16660
– volume: 296
  start-page: E603
  year: 2009
  end-page: E613
  ident: CR94
  article-title: Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.91002.2008
– volume: 287
  start-page: 217
  year: 1992
  end-page: 222
  ident: CR239
  article-title: Liver cell volume and protein synthesis
  publication-title: Biochem J
  doi: 10.1042/bj2870217
– volume: 39
  start-page: 61
  year: 2014
  end-page: 71
  ident: CR230
  article-title: At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy
  publication-title: Trends Biochem Sci
  doi: 10.1016/j.tibs.2013.12.001
– volume: 403
  start-page: 13
  year: 2007
  end-page: 20
  ident: CR65
  article-title: A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling
  publication-title: Biochem J
  doi: 10.1042/BJ20061881
– volume: 105
  start-page: 3374
  year: 2008
  end-page: 3379
  ident: CR139
  article-title: A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0712145105
– volume: 447
  start-page: 303
  year: 1999
  end-page: 306
  ident: CR233
  article-title: Structural requirement of leucine for activation of p70 S6 kinase
  publication-title: FEBS Lett
  doi: 10.1016/S0014-5793(99)00304-X
– volume: 100
  start-page: 914
  year: 2007
  end-page: 922
  ident: CR163
  article-title: Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy
  publication-title: Circ Res
  doi: 10.1161/01.RES.0000261924.76669.36
– volume: 46
  start-page: 210
  year: 2009
  end-page: 240
  ident: CR169
  article-title: Autophagy: regulation and role in disease
  publication-title: Crit Rev Clin Lab Sci
  doi: 10.1080/10408360903044068
– volume: 23
  start-page: 2955
  year: 2012
  end-page: 2962
  ident: CR28
  article-title: Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.E11-12-1034
– ident: CR91
– volume: 24
  start-page: 824
  year: 2013
  end-page: 831
  ident: CR218
  article-title: Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism
  publication-title: J Nutr Biochem
  doi: 10.1016/j.jnutbio.2012.04.018
– volume: 63
  start-page: 547
  year: 1983
  end-page: 605
  ident: CR125
  article-title: Mitochondrial metabolism of glutamine and glutamate and its physiological significance
  publication-title: Physiol Rev
– volume: 29
  start-page: 157
  year: 2009
  end-page: 171
  ident: CR32
  article-title: Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.01082-08
– volume: 23
  start-page: 301
  year: 2013
  end-page: 309
  ident: CR264
  article-title: Autophagosome formation–the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage
  publication-title: Semin Cancer Biol
  doi: 10.1016/j.semcancer.2013.05.007
– volume: 9
  start-page: 1983
  year: 2013
  end-page: 1995
  ident: CR275
  article-title: Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy
  publication-title: Autophagy
  doi: 10.4161/auto.26058
– volume: 272
  start-page: 21661
  year: 1997
  end-page: 21664
  ident: CR86
  article-title: Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome
  publication-title: J Biol Chem
  doi: 10.1074/jbc.272.35.21661
– volume: 19
  start-page: 431
  year: 2014
  end-page: 444
  ident: CR57
  article-title: Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2014.02.010
– volume: 13
  start-page: 215
  year: 2011
  end-page: 221
  ident: CR115
  article-title: Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2011.01.007
– volume: 6
  start-page: 506
  year: 2010
  end-page: 522
  ident: CR198
  article-title: Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation
  publication-title: Autophagy
  doi: 10.4161/auto.6.4.11863
– volume: 10
  start-page: 881
  year: 2008
  end-page: 883
  ident: CR168
  article-title: Nutrient sensing: TOR’s Ragtime
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb0808-881
– volume: 37
  start-page: 633
  year: 2010
  end-page: 642
  ident: CR270
  article-title: PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2010.01.031
– volume: 265
  start-page: 955
  year: 1990
  end-page: 959
  ident: CR11
  article-title: Swelling of rat hepatocytes stimulates glycogen synthesis
  publication-title: J Biol Chem
– volume: 15
  start-page: 1186
  year: 2013
  end-page: 1196
  ident: CR276
  article-title: A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb2822
– volume: 52
  start-page: 495
  year: 2013
  end-page: 505
  ident: CR250
  article-title: The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2013.09.016
– volume: 109
  start-page: 2003
  year: 2012
  end-page: 2008
  ident: CR99
  article-title: Class III PI3 K Vps34 plays an essential role in autophagy and in heart and liver function
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1112848109
– volume: 8
  start-page: 65
  year: 2003
  end-page: 79
  ident: CR120
  article-title: A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway
  publication-title: Genes Cells
  doi: 10.1046/j.1365-2443.2003.00615.x
– volume: 3
  start-page: 177
  year: 2012
  ident: CR272
  article-title: Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
  publication-title: Front Genet
  doi: 10.3389/fgene.2012.00177
– volume: 20
  start-page: 5971
  year: 2001
  end-page: 5981
  ident: CR241
  article-title: The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation
  publication-title: EMBO J
  doi: 10.1093/emboj/20.21.5971
– volume: 169
  start-page: 566
  year: 2006
  end-page: 583
  ident: CR1
  article-title: Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy
  publication-title: Am J Pathol
  doi: 10.2353/ajpath.2006.051066
– volume: 431
  start-page: 200
  year: 2004
  end-page: 205
  ident: CR253
  article-title: Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
  publication-title: Nature
  doi: 10.1038/nature02866
– volume: 496
  start-page: 101
  year: 2013
  end-page: 105
  ident: CR236
  article-title: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
  publication-title: Nature
  doi: 10.1038/nature12040
– volume: 9
  start-page: 124
  year: 2013
  end-page: 137
  ident: CR265
  article-title: The ULK1 complex: sensing nutrient signals for autophagy activation
  publication-title: Autophagy
  doi: 10.4161/auto.23323
– volume: 9
  start-page: e87161
  year: 2014
  ident: CR277
  article-title: Epigallocatechin-3-Gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0087161
– volume: 24
  start-page: 92
  year: 2014
  end-page: 104
  ident: CR41
  article-title: Chaperone-mediated autophagy: roles in disease and aging
  publication-title: Cell Res
  doi: 10.1038/cr.2013.153
– volume: 35
  start-page: 463
  year: 2013
  end-page: 473
  ident: CR117
  article-title: Nutrient regulation of the mTOR complex 1 signaling pathway
  publication-title: Mol Cells
  doi: 10.1007/s10059-013-0138-2
– volume: 280
  start-page: 18717
  year: 2005
  end-page: 18727
  ident: CR235
  article-title: The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M414499200
– volume: 24
  start-page: 73
  year: 2014
  end-page: 81
  ident: CR237
  article-title: The beginning of the end: how scaffolds nucleate autophagosome biogenesis
  publication-title: Trends Cell Biol
  doi: 10.1016/j.tcb.2013.07.008
– volume: 14
  start-page: 829
  year: 2012
  end-page: 837
  ident: CR254
  article-title: Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb2536
– volume: 6
  start-page: 1017
  year: 2010
  end-page: 1031
  ident: CR123
  article-title: The Norse god of autophagy. Interviewed by Daniel J Klionsky
  publication-title: Autophagy
  doi: 10.4161/auto.6.8.13092
– volume: 262
  start-page: 16322
  year: 1987
  end-page: 16327
  ident: CR181
  article-title: Multiphasic control of hepatic protein degradation by regulatory amino acids. General features and hormonal modulation
  publication-title: J Biol Chem
– volume: 48
  start-page: 158
  year: 1992
  end-page: 172
  ident: CR222
  article-title: Autophagy and other vacuolar protein degradation mechanisms
  publication-title: Experientia
  doi: 10.1007/BF01923509
– volume: 52
  start-page: 381
  year: 2012
  end-page: 400
  ident: CR97
  article-title: AMPK and mTOR in cellular energy homeostasis and drug targets
  publication-title: Annu Rev Pharmacol Toxicol
  doi: 10.1146/annurev-pharmtox-010611-134537
– volume: 66
  start-page: 513
  year: 2012
  end-page: 525
  ident: CR137
  article-title: Autophagy, signaling and obesity
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2012.09.003
– volume: 280
  start-page: 23433
  year: 2005
  end-page: 23436
  ident: CR148
  article-title: Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency
  publication-title: J Biol Chem
  doi: 10.1074/jbc.C500169200
– volume: 279
  start-page: 54103
  year: 2004
  end-page: 54109
  ident: CR119
  article-title: Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M410755200
– volume: 22
  start-page: 508
  year: 1994
  end-page: 511
  ident: CR151
  article-title: Cell swelling and the control of autophagic proteolysis in hepatocytes: involvement of phosphorylation of ribosomal protein S6?
  publication-title: Biochem Soc Trans
  doi: 10.1042/bst0220508
– volume: 42
  start-page: 2507
  year: 2012
  end-page: 2512
  ident: CR244
  article-title: The non-proteinogenic amino acids -methionine sulfoximine and DL-phosphinothricin activate mTOR
  publication-title: Amino Acids
  doi: 10.1007/s00726-011-0981-4
– volume: 69
  start-page: 7986
  year: 2009
  end-page: 7993
  ident: CR271
  article-title: Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-09-2266
– volume: 27
  start-page: 19
  year: 2007
  end-page: 40
  ident: CR175
  article-title: Protein turnover via autophagy: implications for metabolism
  publication-title: Annu Rev Nutr
  doi: 10.1146/annurev.nutr.27.061406.093749
– volume: 11
  start-page: 4107
  year: 2012
  end-page: 4108
  ident: CR50
  article-title: Glutaminolysis feeds mTORC1
  publication-title: Cell Cycle
  doi: 10.4161/cc.22632
– volume: 23
  start-page: 361
  year: 2013
  end-page: 379
  ident: CR149
  article-title: Autophagy regulation and its role in cancer
  publication-title: Semin Cancer Biol
  doi: 10.1016/j.semcancer.2013.06.007
– volume: 285
  start-page: E854
  year: 2003
  end-page: E863
  ident: CR154
  article-title: Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00153.2003
– volume: 313
  start-page: 697
  year: 1996
  end-page: 710
  ident: CR82
  article-title: The role of cellular hydration in the regulation of cell function
  publication-title: Biochem J
  doi: 10.1042/bj3130697
– volume: 271
  start-page: 16668
  year: 1996
  end-page: 16673
  ident: CR127
  article-title: Protein kinase signaling pathway triggered by cell swelling and involved in the activation of glycogen synthase and acetyl-CoA carboxylase in isolated rat hepatocytes
  publication-title: J Biol Chem
  doi: 10.1074/jbc.271.51.32523
– volume: 243
  start-page: 240
  year: 1997
  end-page: 246
  ident: CR25
  article-title: The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
  publication-title: Eur J Biochem
  doi: 10.1111/j.1432-1033.1997.0240a.x
– volume: 277
  start-page: 9952
  year: 2002
  end-page: 9957
  ident: CR36
  article-title: Intracellular sensing of amino acids in oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M107694200
– volume: 156
  start-page: 786
  year: 2014
  end-page: 799
  ident: CR44
  article-title: Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2
  publication-title: Cell
  doi: 10.1016/j.cell.2014.01.024
– volume: 521
  start-page: 39
  year: 2002
  end-page: 42
  ident: CR48
  article-title: Hepatic amino acid-dependent signaling is under the control of AMP-dependent protein kinase
  publication-title: FEBS Lett
  doi: 10.1016/S0014-5793(02)02815-6
– volume: 278
  start-page: 887
  year: 1991
  end-page: 890
  ident: CR12
  article-title: Swelling of rat hepatocytes activates acetyl-CoA carboxylase in parallel to glycogen synthase
  publication-title: Biochem J
  doi: 10.1042/bj2780887
– volume: 53
  start-page: 89
  year: 2013
  end-page: 106
  ident: CR229
  article-title: The PI3 K, metabolic, and autophagy networks: interactive partners in cellular health and disease
  publication-title: Annu Rev Pharmacol Toxicol
  doi: 10.1146/annurev-pharmtox-010611-134717
– volume: 340
  start-page: 1100
  year: 2013
  end-page: 1106
  ident: CR15
  article-title: A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
  publication-title: Science
  doi: 10.1126/science.1232044
– volume: 187
  start-page: 249
  year: 2006
  end-page: 255
  ident: CR83
  article-title: The hepatocyte integrin system and cell volume sensing
  publication-title: Acta Physiol (Oxf)
  doi: 10.1111/j.1748-1716.2006.01542.x
– volume: 76
  start-page: 3169
  year: 1979
  end-page: 3173
  ident: CR220
  article-title: Glucagon-induced autophagy and proteolysis in rat liver: mediation by selective deprivation of intracellular amino acids
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.76.7.3169
– volume: 9
  start-page: 218
  year: 2007
  end-page: 224
  ident: CR146
  article-title: The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb1537
– volume: 9
  start-page: 361
  year: 2013
  end-page: 373
  ident: CR165
  article-title: Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2
  publication-title: Autophagy
  doi: 10.4161/auto.23066
– ident: CR58
– volume: 137
  start-page: 191
  year: 1982
  end-page: 201
  ident: CR126
  article-title: Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine
  publication-title: Exp Cell Res
  doi: 10.1016/0014-4827(82)90020-9
– volume: 141
  start-page: 705
  year: 2013
  end-page: 720
  ident: CR98
  article-title: A model of lysosomal pH regulation
  publication-title: J Gen Physiol
  doi: 10.1085/jgp.201210930
– volume: 10
  start-page: 431
  year: 2014
  end-page: 441
  ident: CR210
  article-title: Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids
  publication-title: Autophagy
  doi: 10.4161/auto.27344
– volume: 21
  start-page: 533
  year: 2014
  end-page: 546
  ident: CR100
  article-title: Phospholipase D-mediated autophagic regulation is a potential target for cancer therapy
  publication-title: Cell Death Differ
  doi: 10.1038/cdd.2013.174
– volume: 284
  start-page: 6322
  year: 2009
  end-page: 6328
  ident: CR138
  article-title: Regulation of autophagy by the p300 acetyltransferase
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M807135200
– volume: 33
  start-page: 904
  year: 1999
  end-page: 918
  ident: CR246
  article-title: Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae
  publication-title: Mol Microbiol
  doi: 10.1046/j.1365-2958.1999.01538.x
– volume: 50
  start-page: 353
  year: 2001
  end-page: 360
  ident: CR268
  article-title: Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells
  publication-title: Diabetes
  doi: 10.2337/diabetes.50.2.353
– volume: 287
  start-page: E166
  year: 2004
  end-page: E173
  ident: CR248
  article-title: Possible involvement of the alpha1 isoform of 5′AMP-activated protein kinase in oxidative stress-stimulated glucose transport in skeletal muscle
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00487.2003
– volume: 24
  start-page: 24
  year: 2014
  end-page: 41
  ident: CR63
  article-title: The machinery of macroautophagy
  publication-title: Cell Res
  doi: 10.1038/cr.2013.168
– volume: 630
  start-page: 103
  year: 1980
  end-page: 118
  ident: CR224
  article-title: Amino acid inhibition of the autophagic/lysosomal pathway of protein degradation in isolated rat hepatocytes
  publication-title: Biochim Biophys Acta
  doi: 10.1016/0304-4165(80)90141-5
– volume: 284
  start-page: 8023
  year: 2009
  end-page: 8032
  ident: CR247
  article-title: An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M900301200
– volume: 281
  start-page: 10214
  year: 2006
  end-page: 10221
  ident: CR141
  article-title: Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M512792200
– volume: 30
  start-page: 678
  year: 2008
  end-page: 688
  ident: CR260
  article-title: JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2008.06.001
– volume: 4
  start-page: 006
  year: 2012
  ident: CR69
  article-title: Autophagy - an emerging anti-aging mechanism
  publication-title: J Clin Exp Pathol Suppl
– volume: 37
  start-page: 943
  year: 1990
  end-page: 949
  ident: CR60
  article-title: Regulation of glutamate dehydrogenase by Mg2+ and magnification of leucine activation by Mg2+
  publication-title: Mol Pharmacol
– volume: 8
  start-page: 1875
  year: 2012
  end-page: 1876
  ident: CR104
  article-title: Interpretation of bafilomycin, pH neutralizing or protease inhibitor treatments in autophagic flux experiments: novel considerations
  publication-title: Autophagy
  doi: 10.4161/auto.21544
– volume: 286
  start-page: 25477
  year: 2011
  end-page: 25486
  ident: CR269
  article-title: Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1)
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.249631
– volume: 235
  start-page: 564
  year: 1996
  end-page: 573
  ident: CR152
  article-title: The role of the intralysosomal pH in the control of autophagic proteolytic flux in rat hepatocytes
  publication-title: Eur J Biochem
  doi: 10.1111/j.1432-1033.1996.00564.x-i2
– volume: 47
  start-page: 349
  year: 2012
  end-page: 358
  ident: CR52
  article-title: Glutaminolysis activates Rag-mTORC1 signaling
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2012.05.043
– volume: 40
  start-page: 37
  year: 2012
  end-page: 43
  ident: CR132
  article-title: How phosphoinositide 3-phosphate controls growth downstream of amino acids and autophagy downstream of amino acid withdrawal
  publication-title: Biochem Soc Trans
  doi: 10.1042/BST20110684
– volume: 580
  start-page: 2821
  year: 2006
  end-page: 2829
  ident: CR43
  article-title: The amino acid sensitive TOR pathway from yeast to mammals
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2006.04.068
– volume: 80
  start-page: 1001
  year: 2011
  end-page: 1032
  ident: CR112
  article-title: Amino acid signaling in TOR activation
  publication-title: Annu Rev Biochem
  doi: 10.1146/annurev-biochem-062209-094414
– volume: 29
  start-page: 365
  year: 1997
  end-page: 385
  ident: CR24
  article-title: Autophagic proteolysis: control and specificity
  publication-title: Histochem J
  doi: 10.1023/A:1026486801018
– volume: 9
  start-page: 850
  year: 2013
  end-page: 860
  ident: CR150
  article-title: Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy
  publication-title: Autophagy
  doi: 10.4161/auto.24083
– volume: 79
  start-page: 1889
  year: 1982
  end-page: 1892
  ident: CR223
  article-title: 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.79.6.1889
– volume: 9
  start-page: 1500
  year: 2013
  end-page: 1508
  ident: CR258
  article-title: A novel crosstalk between two major protein degradation systems: regulation of proteasomal activity by autophagy
  publication-title: Autophagy
  doi: 10.4161/auto.25573
– volume: 69
  start-page: 315
  year: 1989
  end-page: 382
  ident: CR87
  article-title: Membrane mechanisms in volume and pH regulation in vertebrate cells
  publication-title: Physiol Rev
– volume: 23
  start-page: 53
  year: 2013
  end-page: 62
  ident: CR38
  article-title: mTOR in aging, metabolism, and cancer
  publication-title: Curr Opin Genet Dev
  doi: 10.1016/j.gde.2012.12.005
– volume: 294
  start-page: 1942
  year: 2001
  end-page: 1945
  ident: CR61
  article-title: Phosphatidic acid-mediated mitogenic activation of mTOR signaling
  publication-title: Science
  doi: 10.1126/science.1066015
– volume: 376
  start-page: 577
  year: 2003
  end-page: 586
  ident: CR245
  article-title: Class III phosphoinositide 3-kinase–Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes
  publication-title: Biochem J
  doi: 10.1042/bj20030826
– volume: 446
  start-page: 8
  year: 2014
  end-page: 14
  ident: CR4
  article-title: Diversity of amino acid signaling pathways on autophagy regulation: a novel pathway for arginine
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2014.01.117
– volume: 274
  start-page: C206
  year: 1998
  end-page: C213
  ident: CR66
  article-title: Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters
  publication-title: Am J Physiol
– volume: 147
  start-page: 728
  year: 2011
  end-page: 741
  ident: CR176
  article-title: Autophagy: renovation of cells and tissues
  publication-title: Cell
  doi: 10.1016/j.cell.2011.10.026
– volume: 136
  start-page: 521
  year: 2009
  end-page: 534
  ident: CR186
  article-title: Bidirectional transport of amino acids regulates mTOR and autophagy
  publication-title: Cell
  doi: 10.1016/j.cell.2008.11.044
– volume: 3
  start-page: 878
  year: 2002
  end-page: 893
  ident: CR59
  article-title: Inhibition of autophagy in mitotic animal cells
  publication-title: Traffic
  doi: 10.1034/j.1600-0854.2002.31204.x
– volume: 10
  start-page: 7
  year: 2012
  end-page: 22
  ident: CR37
  article-title: Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting
  publication-title: Neurodegener Dis
  doi: 10.1159/000334283
– volume: 15
  start-page: 741
  year: 2013
  end-page: 750
  ident: CR208
  article-title: ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb2757
– volume: 20
  start-page: 443
  year: 2014
  end-page: 459
  ident: CR201
  article-title: Reactive oxygen species regulation of autophagy in skeletal muscles
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2013.5410
– volume: 294
  start-page: 1102
  year: 2001
  end-page: 1105
  ident: CR45
  article-title: Mammalian TOR: a homeostatic ATP sensor
  publication-title: Science
  doi: 10.1126/science.1063518
– volume: 288
  start-page: 187
  year: 1980
  end-page: 189
  ident: CR225
  article-title: -leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase
  publication-title: Nature
  doi: 10.1038/288187a0
– volume: 276
  start-page: 38052
  year: 2001
  end-page: 38060
  ident: CR249
  article-title: Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
  publication-title: J Biol Chem
– volume: 13
  start-page: 514
  year: 2013
  end-page: 534
  ident: CR162
  article-title: Glutaminase isoenzymes as key regulators in metabolic and oxidative stress against cancer
  publication-title: Curr Mol Med
  doi: 10.2174/1566524011313040005
– volume: 25
  start-page: 1171
  year: 2014
  end-page: 1185
  ident: CR103
  article-title: Roles for PI(3,5)P2 in nutrient sensing through TORC1
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.E14-01-0021
– volume: 284
  start-page: 12297
  year: 2009
  end-page: 12305
  ident: CR67
  article-title: ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M900573200
– volume: 141
  start-page: 290
  year: 2010
  end-page: 303
  ident: CR212
  article-title: Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
  publication-title: Cell
  doi: 10.1016/j.cell.2010.02.024
– volume: 35
  start-page: 79
  year: 1997
  end-page: 84
  ident: CR101
  article-title: Chloroquine is a potent inhibitor of glutamate dehydrogenase in liver and kidney-cortex of rabbit
  publication-title: Pharmacol Res
  doi: 10.1006/phrs.1996.0108
– volume: 240
  start-page: 182
  year: 2001
  end-page: 193
  ident: CR161
  article-title: Exogenous amino acids regulate trophectoderm differentiation in the mouse blastocyst through an mTOR-dependent pathway
  publication-title: Dev Biol
  doi: 10.1006/dbio.2001.0461
– volume: 35
  start-page: C11
  year: 1967
  end-page: C16
  ident: CR46
  article-title: Participation of lysosomes in cellular autophagy induced in rat liver by glucagon
  publication-title: J Cell Biol
  doi: 10.1083/jcb.35.2.C11
– volume: 23
  start-page: 169
  year: 1904
  end-page: 172
  ident: CR90
  article-title: Notice sur l’action de l’eau oxygenee sur les acides acetoniques et sur les dicetones 1,2
  publication-title: Receuil des Travaux Chimiques des Pays-Bas et de la Belgique
  doi: 10.1002/recl.19040230504
– volume: 445
  start-page: 89
  year: 2008
  end-page: 109
  ident: CR166
  article-title: Amino acid regulation of autophagosome formation
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-59745-157-4_5
– volume: 452
  start-page: 181
  year: 2009
  end-page: 197
  ident: CR21
  article-title: Monitoring autophagic degradation of p62/SQSTM1
  publication-title: Methods Enzymol
  doi: 10.1016/S0076-6879(08)03612-4
– volume: 25
  start-page: 657
  year: 2006
  end-page: 664
  ident: CR205
  article-title: Regulation of the small GTPase Rheb by amino acids
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1209106
– volume: 1824
  start-page: 51
  year: 2012
  end-page: 58
  ident: CR252
  article-title: Metabolic contribution of hepatic autophagic proteolysis: old wine in new bottles
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbapap.2011.06.019
– volume: 1
  start-page: e12
  year: 2010
  ident: CR22
  article-title: Linking calorie restriction to longevity through sirtuins and autophagy: any role for TOR
  publication-title: Cell Death Dis
  doi: 10.1038/cddis.2009.17
– volume: 7
  start-page: 3118
  year: 2008
  end-page: 3123
  ident: CR240
  article-title: mTOR signaling: PLD takes center stage
  publication-title: Cell Cycle
  doi: 10.4161/cc.7.20.6881
– volume: 591
  start-page: 2911
  year: 2013
  end-page: 2923
  ident: CR263
  article-title: Effects of leucine and its metabolite beta-hydroxy-beta-methylbutyrate on human skeletal muscle protein metabolism
  publication-title: J Physiol
  doi: 10.1113/jphysiol.2013.253203
– volume: 12
  start-page: 198
  year: 1962
  end-page: 202
  ident: CR7
  article-title: Cytoplasmic components in hepatic cell lysosomes
  publication-title: J Cell Biol
  doi: 10.1083/jcb.12.1.198
– volume: 115
  start-page: 577
  year: 2003
  end-page: 590
  ident: CR96
  article-title: TSC2 mediates cellular energy response to control cell growth and survival
  publication-title: Cell
  doi: 10.1016/S0092-8674(03)00929-2
– volume: 13
  start-page: 132
  year: 2011
  end-page: 141
  ident: CR114
  article-title: AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb2152
– volume: 81
  start-page: 1152
  year: 2011
  end-page: 1163
  ident: CR142
  article-title: EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2011.02.015
– ident: CR42
– volume: 1
  start-page: 621
  year: 2013
  end-page: 629
  ident: CR85
  article-title: Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: a subanalysis of the EPaNIC trial
  publication-title: Lancet Respir Med
  doi: 10.1016/S2213-2600(13)70183-8
– volume: 15
  start-page: 1135
  year: 2013
  end-page: 1136
  ident: CR17
  article-title: TSC on the peroxisome controls mTORC1
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb2849
– volume: 24
  start-page: 58
  year: 2014
  end-page: 68
  ident: CR231
  article-title: A current perspective of autophagosome biogenesis
  publication-title: Cell Res
  doi: 10.1038/cr.2013.159
– volume: 215
  start-page: 113
  year: 1993
  end-page: 122
  ident: CR89
  article-title: Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors
  publication-title: Eur J Biochem
  doi: 10.1111/j.1432-1033.1993.tb18013.x
– volume: 7
  start-page: 118
  year: 2011
  end-page: 122
  ident: CR131
  article-title: What is the advantage of a transient precursor in autophagosome biogenesis?
  publication-title: Autophagy
  doi: 10.4161/auto.7.1.13697
– volume: 276
  start-page: 35243
  year: 2001
  end-page: 35246
  ident: CR6
  article-title: The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway
  publication-title: J Biol Chem
  doi: 10.1074/jbc.C100319200
– volume: 110
  start-page: 12526
  year: 2013
  end-page: 12534
  ident: CR19
  article-title: Feature article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1302455110
– volume: 20
  start-page: 507
  year: 2014
  end-page: 518
  ident: CR178
  article-title: Oxidative stress and autophagy in cardiovascular homeostasis
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2013.5359
– volume: 9
  start-page: 1004
  year: 2008
  end-page: 1010
  ident: CR130
  article-title: Autophagic cell death: the story of a misnomer
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm2529
– volume: 11
  start-page: 709
  year: 2012
  end-page: 730
  ident: CR206
  article-title: Autophagy modulation as a potential therapeutic target for diverse diseases
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/nrd3802
– volume: 73
  start-page: 3433
  year: 1976
  end-page: 3437
  ident: CR109
  article-title: Stimulation of hepatic glycogen synthesis by amino acids
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.73.10.3433
– volume: 351
  start-page: 545
  year: 2000
  end-page: 550
  ident: CR255
  article-title: Amino-acid-dependent signal transduction
  publication-title: Biochem J
  doi: 10.1042/bj3510545
– volume: 33
  start-page: 98
  year: 2013
  end-page: 110
  ident: CR64
  article-title: Defective autophagy and mTORC1 signaling in myotubularin null mice
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.01075-12
– volume: 53
  start-page: 710
  year: 2014
  end-page: 725
  ident: CR160
  article-title: Regulation of autophagy by cytosolic acetyl-coenzyme A
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2014.01.016
– volume: 24
  start-page: 42
  year: 2014
  end-page: 57
  ident: CR209
  article-title: Autophagy regulation by nutrient signaling
  publication-title: Cell Res
  doi: 10.1038/cr.2013.166
– volume: 10
  start-page: 339
  year: 2014
  end-page: 355
  ident: CR80
  article-title: Inducing autophagy: a comparative phosphoproteomic study of the cellular response to ammonia and rapamycin
  publication-title: Autophagy
  doi: 10.4161/auto.26863
– volume: 24
  start-page: 9
  year: 2014
  end-page: 23
  ident: CR189
  article-title: Historical landmarks of autophagy research
  publication-title: Cell Res
  doi: 10.1038/cr.2013.169
– volume: 279
  start-page: E715
  year: 2000
  end-page: E729
  ident: CR228
  article-title: 4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle
  publication-title: Am J Physiol Endocrinol Metab
– volume: 35
  start-page: 900
  year: 2013
  end-page: 912
  ident: CR217
  article-title: Phosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling
  publication-title: BioEssays
– volume: 28
  start-page: 93
  year: 1985
  end-page: 98
  ident: CR3
  article-title: Pyruvate and related alpha-ketoacids protect mammalian cells in culture against hydrogen peroxide-induced cytotoxicity
  publication-title: Toxicol Lett
  doi: 10.1016/0378-4274(85)90015-3
– volume: 334
  start-page: 261
  year: 1998
  end-page: 267
  ident: CR256
  article-title: Amino acid availability regulates p70 S6 kinase and multiple translation factors
  publication-title: Biochem J
  doi: 10.1042/bj3340261
– volume: 277
  start-page: 23977
  year: 2002
  end-page: 23980
  ident: CR27
  article-title: AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling
  publication-title: J Biol Chem
  doi: 10.1074/jbc.C200171200
– volume: 519
  start-page: 69
  year: 2012
  end-page: 80
  ident: CR144
  article-title: The structure and allosteric regulation of mammalian glutamate dehydrogenase
  publication-title: Arch Biochem Biophys
  doi: 10.1016/j.abb.2011.10.015
– volume: 326
  start-page: 174
  year: 2005
  end-page: 180
  ident: CR184
  article-title: Glutamine is a key regulator for amino acid-controlled cell growth through the mTOR signaling pathway in rat intestinal epithelial cells
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2004.11.015
– volume: 413
  start-page: 209
  year: 1989
  end-page: 216
  ident: CR134
  article-title: Water, K+, H+, lactate and glucose fluxes during cell volume regulation in perfused rat liver
  publication-title: Pflugers Arch
  doi: 10.1007/BF00583532
– volume: 26
  start-page: 1749
  year: 2007
  end-page: 1760
  ident: CR215
  article-title: Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
  publication-title: EMBO J
  doi: 10.1038/sj.emboj.7601623
– volume: 43
  start-page: 541
  year: 2011
  end-page: 564
  ident: CR2
  article-title: Mammalian NADH:ubiquinone oxidoreductase (Complex I) and nicotinamide nucleotide transhydrogenase (Nnt) together regulate the mitochondrial production of H(2)O(2)–implications for their role in disease, especially cancer
  publication-title: J Bioenerg Biomembr
  doi: 10.1007/s10863-011-9381-4
– volume: 37
  start-page: 232
  year: 2009
  end-page: 236
  ident: CR33
  article-title: Nutrient-dependent regulation of autophagy through the target of rapamycin pathway
  publication-title: Biochem Soc Trans
  doi: 10.1042/BST0370232
– volume: 38
  start-page: 1533
  year: 2010
  end-page: 1539
  ident: CR8
  article-title: Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells
  publication-title: Amino Acids
  doi: 10.1007/s00726-009-0377-x
– volume: 182
  start-page: 685
  year: 2008
  end-page: 701
  ident: CR10
  article-title: Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200803137
– volume: 25
  start-page: 193
  year: 2007
  end-page: 205
  ident: CR92
  article-title: Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2006.12.009
– volume: 78
  start-page: 152
  year: 1978
  end-page: 167
  ident: CR196
  article-title: Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy
  publication-title: J Cell Biol
  doi: 10.1083/jcb.78.1.152
– volume: 18
  start-page: 524
  year: 2012
  end-page: 533
  ident: CR54
  article-title: Amino acids and mTORC1: from lysosomes to disease
  publication-title: Trends Mol Med
  doi: 10.1016/j.molmed.2012.05.007
– volume: 154
  start-page: 1285
  year: 2013
  end-page: 1299
  ident: CR199
  article-title: Diverse autophagosome membrane sources coalesce in recycling endosomes
  publication-title: Cell
  doi: 10.1016/j.cell.2013.08.044
– volume: 5
  start-page: 3207
  year: 2014
  ident: CR34
  article-title: Yeast and mammalian autophagosomes exhibit distinct phosphatidylinositol 3-phosphate asymmetries
  publication-title: Nat Commun
– volume: 24
  start-page: 69
  year: 2014
  end-page: 79
  ident: CR102
  article-title: Autophagy and human diseases
  publication-title: Cell Res
  doi: 10.1038/cr.2013.161
– volume: 53
  start-page: 1399
  year: 2012
  end-page: 1410
  ident: CR143
  article-title: Reactive oxygen species regulation of autophagy in cancer: implications for cancer treatment
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2012.07.011
– volume: 133
  start-page: 2052S
  year: 2003
  end-page: 2056S
  ident: CR107
  article-title: Amino acids as regulators of proteolysis
  publication-title: J Nutr
– volume: 14
  start-page: 6306
  year: 2013
  end-page: 6344
  ident: CR26
  article-title: Mitochondria and reactive oxygen species: physiology and pathophysiology
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms14036306
– volume: 30
  start-page: 214
  year: 2008
  end-page: 226
  ident: CR73
  article-title: AMPK phosphorylation of raptor mediates a metabolic checkpoint
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2008.03.003
– volume: 273
  start-page: 3963
  year: 1998
  end-page: 3966
  ident: CR188
  article-title: Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
  publication-title: J Biol Chem
  doi: 10.1074/jbc.273.7.3963
– volume: 273
  start-page: 14484
  year: 1998
  end-page: 14494
  ident: CR79
  article-title: Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
  publication-title: J Biol Chem
  doi: 10.1074/jbc.273.23.14484
– volume: 203
  start-page: 563
  year: 2013
  end-page: 574
  ident: CR18
  article-title: Where is mTOR and what is it doing there?
  publication-title: J Cell Biol
  doi: 10.1083/jcb.201306041
– ident: CR55
– volume: 331
  start-page: 456
  year: 2011
  end-page: 461
  ident: CR56
  article-title: Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
  publication-title: Science
  doi: 10.1126/science.1196371
– volume: 80
  start-page: 1066
  year: 2011
  end-page: 1075
  ident: CR197
  article-title: Ca2+/calmodulin-dependent kinase (CaMK) signaling via CaMKI and AMP-activated protein kinase contributes to the regulation of WIPI-1 at the onset of autophagy
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.111.071761
– volume: 22
  start-page: 159
  year: 2006
  end-page: 168
  ident: CR213
  article-title: Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2006.03.029
– volume: 122
  start-page: 927
  year: 2005
  end-page: 939
  ident: CR192
  article-title: Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
  publication-title: Cell
  doi: 10.1016/j.cell.2005.07.002
– volume: 296
  start-page: E592
  year: 2009
  end-page: E602
  ident: CR9
  article-title: Amino acid regulation of TOR complex 1
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.90645.2008
– volume: 15
  start-page: 725
  year: 2012
  end-page: 738
  ident: CR74
  article-title: Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2012.03.015
– volume: 152
  start-page: 290
  year: 2013
  end-page: 303
  ident: CR116
  article-title: Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy
  publication-title: Cell
  doi: 10.1016/j.cell.2012.12.016
– volume: 102
  start-page: 14238
  year: 2005
  end-page: 14243
  ident: CR187
  article-title: Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0506925102
– volume: 113
  start-page: 1305
  year: 1991
  end-page: 1312
  ident: CR93
  article-title: Inhibition of autophagic-lysosomal delivery and autophagic lactolysis by asparagine
  publication-title: J Cell Biol
  doi: 10.1083/jcb.113.6.1305
– volume: 320
  start-page: 1496
  year: 2008
  end-page: 1501
  ident: CR211
  article-title: The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
  publication-title: Science
  doi: 10.1126/science.1157535
– volume: 465
  start-page: 942
  year: 2010
  end-page: 946
  ident: CR274
  article-title: Termination of autophagy and reformation of lysosomes regulated by mTOR
  publication-title: Nature
  doi: 10.1038/nature09076
– volume: 25
  start-page: 50
  year: 2013
  end-page: 65
  ident: CR145
  article-title: Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation
  publication-title: Cell Signal
  doi: 10.1016/j.cellsig.2012.09.020
– volume: 281
  start-page: 27643
  year: 2006
  end-page: 27652
  ident: CR216
  article-title: The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M603536200
– volume: 10
  start-page: 935
  year: 2008
  end-page: 945
  ident: CR113
  article-title: Regulation of TORC1 by Rag GTPases in nutrient response
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb1753
– volume: 274
  start-page: 11647
  year: 1999
  end-page: 11652
  ident: CR118
  article-title: Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.17.11647
– volume: 106
  start-page: 17049
  year: 2009
  end-page: 17054
  ident: CR238
  article-title: The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0903316106
– volume: 3
  start-page: 130185
  year: 2013
  ident: CR71
  article-title: Rheb and mammalian target of rapamycin in mitochondrial homoeostasis
  publication-title: Open Biol
  doi: 10.1098/rsob.130185
– volume: 202
  start-page: 1107
  year: 2013
  end-page: 1122
  ident: CR194
  article-title: Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases
  publication-title: J Cell Biol
  doi: 10.1083/jcb.201307084
– volume: 287
  start-page: 38625
  year: 2012
  end-page: 38636
  ident: CR70
  article-title: Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulin-dependent kinase kinase-beta (CaMKK-beta)
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M112.365767
– volume: 80
  start-page: 541
  year: 2002
  end-page: 552
  ident: CR177
  article-title: Control of proteolysis by norepinephrine and insulin in brown adipocytes: role of ATP, phosphatidylinositol 3-kinase, and p70 S6K
  publication-title: Can J Physiol Pharmacol
  doi: 10.1139/y02-078
– volume: 298
  start-page: E751
  year: 2010
  end-page: E760
  ident: CR207
  article-title: AMPK and SIRT1: a long-standing partnership?
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00745.2009
– volume: 186
  start-page: 773
  year: 2009
  end-page: 782
  ident: CR234
  article-title: Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200907014
– volume: 26
  start-page: 63
  year: 2006
  end-page: 76
  ident: CR251
  article-title: Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.26.1.63-76.2006
– volume: 21
  start-page: 348
  year: 2014
  end-page: 358
  ident: CR5
  article-title: Regulation of autophagy by the Rab GTPase network
  publication-title: Cell Death Differ
  doi: 10.1038/cdd.2013.187
– volume: 197
  start-page: 717
  year: 1991
  end-page: 724
  ident: CR76
  article-title: Control of hepatic proteolysis by amino acids. The role of cell volume
  publication-title: Eur J Biochem
  doi: 10.1111/j.1432-1033.1991.tb15963.x
– volume: 152
  start-page: 519
  year: 2001
  end-page: 530
  ident: CR111
  article-title: Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in
  publication-title: J Cell Biol
  doi: 10.1083/jcb.152.3.519
– volume: 25
  start-page: 1235
  year: 2013
  end-page: 1244
  ident: CR243
  article-title: Post-translational regulation of mTOR complex 1 in hypoxia and reoxygenation
  publication-title: Cell Signal
  doi: 10.1016/j.cellsig.2013.02.012
– volume: 372
  start-page: 555
  year: 2003
  end-page: 566
  ident: CR20
  article-title: Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability
  publication-title: Biochem J
  doi: 10.1042/bj20021266
– volume: 279
  start-page: 8452
  year: 2004
  end-page: 8459
  ident: CR108
  article-title: Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M306337200
– volume: 8
  start-page: 774
  year: 2007
  end-page: 785
  ident: CR81
  article-title: AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm2249
– volume: 107
  start-page: 207
  year: 1977
  end-page: 217
  ident: CR221
  article-title: Inhibitor of protein degradation formed during incubation of isolated rat hepatocytes in a cell culture medium. Its identification as ammonia
  publication-title: Exp Cell Res
  doi: 10.1016/0014-4827(77)90402-5
– volume: 6
  start-page: 269
  year: 2000
  end-page: 279
  ident: CR47
  article-title: Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain
  publication-title: Mol Cell
  doi: 10.1016/S1097-2765(00)00028-9
– volume: 245
  start-page: 2375
  year: 1970
  end-page: 2383
  ident: CR180
  article-title: Inhibition by insulin of valine turnover in liver. Evidence for a general control of proteolysis
  publication-title: J Biol Chem
– volume: 150
  start-page: 1196
  year: 2012
  end-page: 1208
  ident: CR14
  article-title: Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1
  publication-title: Cell
  doi: 10.1016/j.cell.2012.07.032
– volume: 284
  start-page: 633
  year: 1992
  end-page: 636
  ident: CR88
  article-title: Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity
  publication-title: Biochem J
  doi: 10.1042/bj2840633
– volume: 20
  start-page: 1992
  year: 2009
  end-page: 2003
  ident: CR105
  article-title: ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.E08-12-1249
– volume: 274
  start-page: 1092
  year: 1999
  end-page: 1099
  ident: CR95
  article-title: Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.2.1092
– volume: 5
  start-page: 3
  year: 2009
  end-page: 5
  ident: CR167
  article-title: Autophagy research: lessons from metabolism
  publication-title: Autophagy
  doi: 10.4161/auto.5.1.7207
– volume: 253
  start-page: 905
  year: 1991
  end-page: 909
  ident: CR84
  article-title: Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
  publication-title: Science
  doi: 10.1126/science.1715094
– volume: 14
  start-page: 173
  year: 2011
  end-page: 183
  ident: CR110
  article-title: Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2011.06.008
– volume: 281
  start-page: 34870
  year: 2006
  end-page: 34879
  ident: CR173
  article-title: AMP-activated protein kinase and the regulation of autophagic proteolysis
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M605488200
– volume: 156
  start-page: 771
  year: 2014
  end-page: 785
  ident: CR174
  article-title: Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome
  publication-title: Cell
  doi: 10.1016/j.cell.2013.11.049
– volume: 275
  start-page: 992
  year: 2000
  end-page: 998
  ident: CR193
  article-title: Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells
  publication-title: J Biol Chem
  doi: 10.1074/jbc.275.2.992
– volume: 5
  start-page: e13
  year: 2012
  ident: CR262
  article-title: Phospholipase D and mTORC1: nutrients are what bring them together
  publication-title: Sci Signal
  doi: 10.1126/scisignal.2003019
– volume: 149
  start-page: 274
  year: 2012
  end-page: 293
  ident: CR135
  article-title: mTOR signaling in growth control and disease
  publication-title: Cell
  doi: 10.1016/j.cell.2012.03.017
– volume: 21
  start-page: R227
  year: 2011
  end-page: R229
  ident: CR170
  article-title: Autophagy: regulation by energy sensing
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2011.02.007
– volume: 36
  start-page: 1691
  year: 1977
  end-page: 1694
  ident: CR195
  article-title: Inhibition by insulin of the physiological autophagic breakdown of cell organelles
  publication-title: Acta Biol Med Ger
– volume: 149
  start-page: 410
  year: 2012
  end-page: 424
  ident: CR78
  article-title: Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
  publication-title: Cell
  doi: 10.1016/j.cell.2012.02.044
– volume: 101
  start-page: 1519
  year: 1998
  end-page: 1529
  ident: CR191
  article-title: Bidirectional modulation of insulin action by amino acids
  publication-title: J Clin Invest
  doi: 10.1172/JCI1326
– volume: 275
  start-page: 29900
  year: 2000
  end-page: 29906
  ident: CR179
  article-title: Leucine limitation induces autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of rapamycin-independent signaling pathway
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M003633200
– volume: 32
  start-page: 4549
  year: 2013
  end-page: 4556
  ident: CR53
  article-title: HIF-independent role of prolyl hydroxylases in the cellular response to amino acids
  publication-title: Oncogene
  doi: 10.1038/onc.2012.465
– volume: 289
  start-page: 2658
  year: 2013
  end-page: 2674
  ident: CR190
  article-title: Amino acids activate mTOR complex1 without changing Rag GTPase guanyl nucleotide charging
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M113.528505
– volume: 44
  start-page: 134
  year: 2011
  end-page: 146
  ident: CR51
  article-title: p62 is a key regulator of nutrient sensing in the mTORC1 pathway
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2011.06.038
– volume: 280
  start-page: 6322
  year: 2013
  end-page: 6337
  ident: CR62
  article-title: Phosphoinositide 3-kinases as accelerators and brakes of autophagy
  publication-title: FEBS J
  doi: 10.1111/febs.12486
– volume: 277
  start-page: 34826
  year: 2002
  end-page: 34835
  ident: CR136
  article-title: Naringin-sensitive phosphorylation of plectin, a cytoskeletal cross-linking protein, in isolated rat hepatocytes
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M205028200
– volume: 129
  start-page: 1261
  year: 2007
  end-page: 1274
  ident: CR157
  article-title: AKT/PKB signaling: navigating downstream
  publication-title: Cell
  doi: 10.1016/j.cell.2007.06.009
– volume: 219
  start-page: 455
  year: 1987
  end-page: 458
  ident: CR140
  article-title: Control of proteolysis in perifused rat hepatocytes
  publication-title: FEBS Lett
  doi: 10.1016/0014-5793(87)80271-5
– volume: 6
  start-page: 458
  year: 2007
  end-page: 471
  ident: CR156
  article-title: FoxO3 controls autophagy in skeletal muscle in vivo
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2007.11.001
– volume: 215
  start-page: 449
  year: 1993
  end-page: 454
  ident: CR172
  article-title: Cell swelling and the sensitivity of autophagic proteolysis to inhibition by amino acids in isolated rat hepatocytes
  publication-title: Eur J Biochem
  doi: 10.1111/j.1432-1033.1993.tb18053.x
– volume: 338
  start-page: 956
  year: 2012
  end-page: 959
  ident: CR257
  article-title: Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation
  publication-title: Science
  doi: 10.1126/science.1225967
– volume: 80
  start-page: 125
  year: 2011
  end-page: 156
  ident: CR261
  article-title: Biogenesis and cargo selectivity of autophagosomes
  publication-title: Annu Rev Biochem
  doi: 10.1146/annurev-biochem-052709-094552
– ident: CR124
– volume: 270
  start-page: 2320
  year: 1995
  end-page: 2326
  ident: CR23
  article-title: Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes
  publication-title: J Biol Chem
  doi: 10.1074/jbc.270.5.2320
– volume: 77
  start-page: 234
  year: 2000
  end-page: 251
  ident: CR153
  article-title: Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes
  publication-title: J Cell Biochem
  doi: 10.1002/(SICI)1097-4644(20000501)77:2<234::AID-JCB7>3.0.CO;2-I
– volume: 267
  start-page: 5823
  year: 1992
  end-page: 5828
  ident: CR171
  article-title: Mechanism of activation of liver glycogen synthase by swelling
  publication-title: J Biol Chem
– volume: 10
  start-page: 356
  year: 2014
  end-page: 371
  ident: CR204
  article-title: Characterization of early autophagy signaling by quantitative phosphoproteomics
  publication-title: Autophagy
  doi: 10.4161/auto.26864
– volume: 458
  start-page: 1056
  year: 2009
  end-page: 1060
  ident: CR29
  article-title: AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
  publication-title: Nature
  doi: 10.1038/nature07813
– volume: 31
  start-page: 1095
  year: 2012
  end-page: 1108
  ident: CR227
  article-title: A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
  publication-title: EMBO J
  doi: 10.1038/emboj.2012.32
– volume: 8
  start-page: 931
  year: 2007
  end-page: 937
  ident: CR121
  article-title: Autophagy: from phenomenology to molecular understanding in less than a decade
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm2245
– volume: 368
  start-page: 651
  year: 2013
  end-page: 662
  ident: CR35
  article-title: Autophagy in human health and disease
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra1205406
– volume: 15
  start-page: 81
  year: 2014
  end-page: 94
  ident: CR159
  article-title: Self-consumption: the interplay of autophagy and apoptosis
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm3735
– volume: 14
  start-page: 759
  year: 2013
  end-page: 774
  ident: CR133
  article-title: The autophagosome: origins unknown, biogenesis complex
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm3696
– volume: 496
  start-page: 101
  year: 2013
  ident: 1765_CR236
  publication-title: Nature
  doi: 10.1038/nature12040
– volume: 269
  start-page: 3751
  year: 2002
  ident: 1765_CR128
  publication-title: Eur J Biochem
  doi: 10.1046/j.1432-1033.2002.03074.x
– volume: 285
  start-page: 34447
  year: 2010
  ident: 1765_CR203
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M110.133579
– volume: 40
  start-page: 37
  year: 2012
  ident: 1765_CR132
  publication-title: Biochem Soc Trans
  doi: 10.1042/BST20110684
– volume: 235
  start-page: 564
  year: 1996
  ident: 1765_CR152
  publication-title: Eur J Biochem
  doi: 10.1111/j.1432-1033.1996.00564.x-i2
– volume: 5
  start-page: 3207
  year: 2014
  ident: 1765_CR34
  publication-title: Nat Commun
  doi: 10.1038/ncomms4207
– volume: 277
  start-page: 9952
  year: 2002
  ident: 1765_CR36
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M107694200
– ident: 1765_CR91
  doi: 10.1111/jcmm.12257
– volume: 3
  start-page: 177
  year: 2012
  ident: 1765_CR272
  publication-title: Front Genet
– volume: 298
  start-page: E751
  year: 2010
  ident: 1765_CR207
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00745.2009
– volume: 18
  start-page: 1533
  year: 2004
  ident: 1765_CR39
  publication-title: Genes Dev
  doi: 10.1101/gad.1199104
– volume: 73
  start-page: 3433
  year: 1976
  ident: 1765_CR109
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.73.10.3433
– volume: 7
  start-page: 456
  year: 2008
  ident: 1765_CR72
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2008.03.002
– volume: 262
  start-page: 16322
  year: 1987
  ident: 1765_CR181
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)49257-5
– volume: 10
  start-page: 935
  year: 2008
  ident: 1765_CR113
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb1753
– volume: 44
  start-page: 134
  year: 2011
  ident: 1765_CR51
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2011.06.038
– volume: 69
  start-page: 7986
  year: 2009
  ident: 1765_CR271
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-09-2266
– volume: 181
  start-page: 717
  year: 1989
  ident: 1765_CR30
  publication-title: Eur J Biochem
  doi: 10.1111/j.1432-1033.1989.tb14782.x
– volume: 263
  start-page: 19545
  year: 1988
  ident: 1765_CR182
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(19)77670-4
– volume: 281
  start-page: 34870
  year: 2006
  ident: 1765_CR173
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M605488200
– ident: 1765_CR42
  doi: 10.1038/ncomms1144
– volume: 156
  start-page: 786
  year: 2014
  ident: 1765_CR44
  publication-title: Cell
  doi: 10.1016/j.cell.2014.01.024
– volume: 332
  start-page: 1429
  year: 2011
  ident: 1765_CR226
  publication-title: Science
  doi: 10.1126/science.1204592
– volume: 26
  start-page: 1749
  year: 2007
  ident: 1765_CR215
  publication-title: EMBO J
  doi: 10.1038/sj.emboj.7601623
– volume: 156
  start-page: 771
  year: 2014
  ident: 1765_CR174
  publication-title: Cell
  doi: 10.1016/j.cell.2013.11.049
– volume: 106
  start-page: 22229
  year: 2009
  ident: 1765_CR202
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0912074106
– volume: 109
  start-page: 2003
  year: 2012
  ident: 1765_CR99
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1112848109
– volume: 14
  start-page: 759
  year: 2013
  ident: 1765_CR133
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm3696
– ident: 1765_CR124
  doi: 10.4161/auto.19496
– volume: 81
  start-page: 1152
  year: 2011
  ident: 1765_CR142
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2011.02.015
– volume: 77
  start-page: 234
  year: 2000
  ident: 1765_CR153
  publication-title: J Cell Biochem
  doi: 10.1002/(SICI)1097-4644(20000501)77:2<234::AID-JCB7>3.0.CO;2-I
– volume: 3
  start-page: 878
  year: 2002
  ident: 1765_CR59
  publication-title: Traffic
  doi: 10.1034/j.1600-0854.2002.31204.x
– volume: 79
  start-page: 1889
  year: 1982
  ident: 1765_CR223
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.79.6.1889
– volume: 5
  start-page: e13
  year: 2012
  ident: 1765_CR262
  publication-title: Sci Signal
  doi: 10.1126/scisignal.2003019
– volume: 43
  start-page: 541
  year: 2011
  ident: 1765_CR2
  publication-title: J Bioenerg Biomembr
  doi: 10.1007/s10863-011-9381-4
– volume: 3
  start-page: 130185
  year: 2013
  ident: 1765_CR71
  publication-title: Open Biol
  doi: 10.1098/rsob.130185
– volume: 150
  start-page: 1196
  year: 2012
  ident: 1765_CR14
  publication-title: Cell
  doi: 10.1016/j.cell.2012.07.032
– volume: 8
  start-page: 774
  year: 2007
  ident: 1765_CR81
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm2249
– volume: 21
  start-page: 533
  year: 2014
  ident: 1765_CR100
  publication-title: Cell Death Differ
  doi: 10.1038/cdd.2013.174
– volume: 105
  start-page: 3374
  year: 2008
  ident: 1765_CR139
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0712145105
– volume: 23
  start-page: 2955
  year: 2012
  ident: 1765_CR28
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.E11-12-1034
– volume: 60
  start-page: 746
  year: 2011
  ident: 1765_CR266
  publication-title: Diabetes
  doi: 10.2337/db10-1246
– volume: 296
  start-page: E592
  year: 2009
  ident: 1765_CR9
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.90645.2008
– volume: 15
  start-page: 1135
  year: 2013
  ident: 1765_CR17
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb2849
– volume: 287
  start-page: E166
  year: 2004
  ident: 1765_CR248
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00487.2003
– volume: 274
  start-page: 1092
  year: 1999
  ident: 1765_CR95
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.2.1092
– volume: 8
  start-page: 719
  year: 2012
  ident: 1765_CR147
  publication-title: Autophagy
  doi: 10.4161/auto.19469
– volume: 10
  start-page: 881
  year: 2008
  ident: 1765_CR168
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb0808-881
– volume: 153
  start-page: 840
  year: 2013
  ident: 1765_CR40
  publication-title: Cell
  doi: 10.1016/j.cell.2013.04.023
– volume: 14
  start-page: 173
  year: 2011
  ident: 1765_CR110
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2011.06.008
– volume: 7
  start-page: 3118
  year: 2008
  ident: 1765_CR240
  publication-title: Cell Cycle
  doi: 10.4161/cc.7.20.6881
– volume: 106
  start-page: 17049
  year: 2009
  ident: 1765_CR238
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0903316106
– volume: 80
  start-page: 1066
  year: 2011
  ident: 1765_CR197
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.111.071761
– volume: 113
  start-page: 1305
  year: 1991
  ident: 1765_CR93
  publication-title: J Cell Biol
  doi: 10.1083/jcb.113.6.1305
– volume: 28
  start-page: 93
  year: 1985
  ident: 1765_CR3
  publication-title: Toxicol Lett
  doi: 10.1016/0378-4274(85)90015-3
– volume: 521
  start-page: 39
  year: 2002
  ident: 1765_CR48
  publication-title: FEBS Lett
  doi: 10.1016/S0014-5793(02)02815-6
– volume: 446
  start-page: 8
  year: 2014
  ident: 1765_CR4
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2014.01.117
– volume: 279
  start-page: E715
  year: 2000
  ident: 1765_CR228
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.2000.279.4.E715
– volume: 15
  start-page: 1186
  year: 2013
  ident: 1765_CR276
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb2822
– volume: 154
  start-page: 1285
  year: 2013
  ident: 1765_CR199
  publication-title: Cell
  doi: 10.1016/j.cell.2013.08.044
– volume: 37
  start-page: 943
  year: 1990
  ident: 1765_CR60
  publication-title: Mol Pharmacol
  doi: 10.1016/S0026-895X(25)11054-7
– volume: 53
  start-page: 1399
  year: 2012
  ident: 1765_CR143
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2012.07.011
– volume: 445
  start-page: 89
  year: 2008
  ident: 1765_CR166
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-59745-157-4_5
– volume: 23
  start-page: 169
  year: 1904
  ident: 1765_CR90
  publication-title: Receuil des Travaux Chimiques des Pays-Bas et de la Belgique
  doi: 10.1002/recl.19040230504
– volume: 9
  start-page: 361
  year: 2013
  ident: 1765_CR165
  publication-title: Autophagy
  doi: 10.4161/auto.23066
– volume: 273
  start-page: 28178
  year: 1998
  ident: 1765_CR267
  publication-title: J Biol Chem
  doi: 10.1074/jbc.273.43.28178
– volume: 245
  start-page: 2375
  year: 1970
  ident: 1765_CR180
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)63163-1
– volume: 187
  start-page: 249
  year: 2006
  ident: 1765_CR83
  publication-title: Acta Physiol (Oxf)
  doi: 10.1111/j.1748-1716.2006.01542.x
– volume: 9
  start-page: 218
  year: 2007
  ident: 1765_CR146
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb1537
– volume: 26
  start-page: 63
  year: 2006
  ident: 1765_CR251
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.26.1.63-76.2006
– volume: 24
  start-page: 824
  year: 2013
  ident: 1765_CR218
  publication-title: J Nutr Biochem
  doi: 10.1016/j.jnutbio.2012.04.018
– volume: 274
  start-page: C206
  year: 1998
  ident: 1765_CR66
  publication-title: Am J Physiol
  doi: 10.1152/ajpcell.1998.274.1.C206
– volume: 28
  start-page: 6
  year: 2013
  ident: 1765_CR200
  publication-title: Endocrinol Metab (Seoul)
  doi: 10.3803/EnM.2013.28.1.6
– volume: 53
  start-page: 710
  year: 2014
  ident: 1765_CR160
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2014.01.016
– volume: 149
  start-page: 410
  year: 2012
  ident: 1765_CR78
  publication-title: Cell
  doi: 10.1016/j.cell.2012.02.044
– volume: 182
  start-page: 685
  year: 2008
  ident: 1765_CR10
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200803137
– volume: 1
  start-page: 4
  year: 2008
  ident: 1765_CR31
  publication-title: Curr Aging Sci
  doi: 10.2174/1874609810801010004
– volume: 368
  start-page: 651
  year: 2013
  ident: 1765_CR35
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra1205406
– volume: 287
  start-page: 38625
  year: 2012
  ident: 1765_CR70
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M112.365767
– volume: 289
  start-page: 2658
  year: 2013
  ident: 1765_CR190
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M113.528505
– volume: 32
  start-page: 4549
  year: 2013
  ident: 1765_CR53
  publication-title: Oncogene
  doi: 10.1038/onc.2012.465
– volume: 48
  start-page: 158
  year: 1992
  ident: 1765_CR222
  publication-title: Experientia
  doi: 10.1007/BF01923509
– volume: 403
  start-page: 13
  year: 2007
  ident: 1765_CR65
  publication-title: Biochem J
  doi: 10.1042/BJ20061881
– volume: 276
  start-page: 35243
  year: 2001
  ident: 1765_CR6
  publication-title: J Biol Chem
  doi: 10.1074/jbc.C100319200
– volume: 47
  start-page: 349
  year: 2012
  ident: 1765_CR52
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2012.05.043
– volume: 303
  start-page: E1117
  year: 2012
  ident: 1765_CR13
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00067.2012
– volume: 33
  start-page: 98
  year: 2013
  ident: 1765_CR64
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.01075-12
– volume: 10
  start-page: 431
  year: 2014
  ident: 1765_CR210
  publication-title: Autophagy
  doi: 10.4161/auto.27344
– volume: 7
  start-page: 1212
  year: 2011
  ident: 1765_CR106
  publication-title: Autophagy
  doi: 10.4161/auto.7.10.16660
– volume: 580
  start-page: 2821
  year: 2006
  ident: 1765_CR43
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2006.04.068
– volume: 331
  start-page: 456
  year: 2011
  ident: 1765_CR56
  publication-title: Science
  doi: 10.1126/science.1196371
– volume: 591
  start-page: 2911
  year: 2013
  ident: 1765_CR263
  publication-title: J Physiol
  doi: 10.1113/jphysiol.2013.253203
– volume: 270
  start-page: 2320
  year: 1995
  ident: 1765_CR23
  publication-title: J Biol Chem
  doi: 10.1074/jbc.270.5.2320
– volume: 22
  start-page: 1207
  year: 2012
  ident: 1765_CR49
  publication-title: Cell Res
  doi: 10.1038/cr.2012.68
– volume: 452
  start-page: 25
  year: 2009
  ident: 1765_CR75
  publication-title: Methods Enzymol
  doi: 10.1016/S0076-6879(08)03603-3
– volume: 21
  start-page: 348
  year: 2014
  ident: 1765_CR5
  publication-title: Cell Death Differ
  doi: 10.1038/cdd.2013.187
– volume: 25
  start-page: 1235
  year: 2013
  ident: 1765_CR243
  publication-title: Cell Signal
  doi: 10.1016/j.cellsig.2013.02.012
– volume: 338
  start-page: 956
  year: 2012
  ident: 1765_CR257
  publication-title: Science
  doi: 10.1126/science.1225967
– volume: 274
  start-page: 1058
  year: 1999
  ident: 1765_CR232
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.2.1058
– volume: 41
  start-page: 7683
  year: 2013
  ident: 1765_CR16
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkt563
– volume: 6
  start-page: 506
  year: 2010
  ident: 1765_CR198
  publication-title: Autophagy
  doi: 10.4161/auto.6.4.11863
– volume: 14
  start-page: 6306
  year: 2013
  ident: 1765_CR26
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms14036306
– volume: 197
  start-page: 717
  year: 1991
  ident: 1765_CR76
  publication-title: Eur J Biochem
  doi: 10.1111/j.1432-1033.1991.tb15963.x
– volume: 23
  start-page: 361
  year: 2013
  ident: 1765_CR149
  publication-title: Semin Cancer Biol
  doi: 10.1016/j.semcancer.2013.06.007
– volume: 186
  start-page: 773
  year: 2009
  ident: 1765_CR234
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200907014
– volume: 152
  start-page: 519
  year: 2001
  ident: 1765_CR111
  publication-title: J Cell Biol
  doi: 10.1083/jcb.152.3.519
– volume: 33
  start-page: 904
  year: 1999
  ident: 1765_CR246
  publication-title: Mol Microbiol
  doi: 10.1046/j.1365-2958.1999.01538.x
– volume: 102
  start-page: 14238
  year: 2005
  ident: 1765_CR187
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0506925102
– volume: 69
  start-page: 315
  year: 1989
  ident: 1765_CR87
  publication-title: Physiol Rev
  doi: 10.1152/physrev.1989.69.2.315
– volume: 52
  start-page: 381
  year: 2012
  ident: 1765_CR97
  publication-title: Annu Rev Pharmacol Toxicol
  doi: 10.1146/annurev-pharmtox-010611-134537
– volume: 35
  start-page: 463
  year: 2013
  ident: 1765_CR117
  publication-title: Mol Cells
  doi: 10.1007/s10059-013-0138-2
– volume: 46
  start-page: 210
  year: 2009
  ident: 1765_CR169
  publication-title: Crit Rev Clin Lab Sci
  doi: 10.1080/10408360903044068
– volume: 15
  start-page: 725
  year: 2012
  ident: 1765_CR74
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2012.03.015
– volume: 275
  start-page: 992
  year: 2000
  ident: 1765_CR193
  publication-title: J Biol Chem
  doi: 10.1074/jbc.275.2.992
– volume: 29
  start-page: 157
  year: 2009
  ident: 1765_CR32
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.01082-08
– volume: 35
  start-page: 79
  year: 1997
  ident: 1765_CR101
  publication-title: Pharmacol Res
  doi: 10.1006/phrs.1996.0108
– volume: 9
  start-page: 1004
  year: 2008
  ident: 1765_CR130
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm2529
– volume: 287
  start-page: 217
  year: 1992
  ident: 1765_CR239
  publication-title: Biochem J
  doi: 10.1042/bj2870217
– volume: 2
  start-page: e00947
  year: 2013
  ident: 1765_CR68
  publication-title: Elife
  doi: 10.7554/eLife.00947
– volume: 280
  start-page: 6322
  year: 2013
  ident: 1765_CR62
  publication-title: FEBS J
  doi: 10.1111/febs.12486
– volume: 22
  start-page: 159
  year: 2006
  ident: 1765_CR213
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2006.03.029
– volume: 294
  start-page: 1102
  year: 2001
  ident: 1765_CR45
  publication-title: Science
  doi: 10.1126/science.1063518
– volume: 340
  start-page: 1100
  year: 2013
  ident: 1765_CR15
  publication-title: Science
  doi: 10.1126/science.1232044
– volume: 202
  start-page: 1107
  year: 2013
  ident: 1765_CR194
  publication-title: J Cell Biol
  doi: 10.1083/jcb.201307084
– volume: 195
  start-page: 435
  year: 2011
  ident: 1765_CR273
  publication-title: J Cell Biol
  doi: 10.1083/jcb.201107033
– volume: 284
  start-page: 633
  year: 1992
  ident: 1765_CR88
  publication-title: Biochem J
  doi: 10.1042/bj2840633
– volume: 376
  start-page: 577
  year: 2003
  ident: 1765_CR245
  publication-title: Biochem J
  doi: 10.1042/bj20030826
– volume: 63
  start-page: 547
  year: 1983
  ident: 1765_CR125
  publication-title: Physiol Rev
  doi: 10.1152/physrev.1983.63.2.547
– volume: 25
  start-page: 50
  year: 2013
  ident: 1765_CR145
  publication-title: Cell Signal
  doi: 10.1016/j.cellsig.2012.09.020
– volume: 169
  start-page: 566
  year: 2006
  ident: 1765_CR1
  publication-title: Am J Pathol
  doi: 10.2353/ajpath.2006.051066
– volume: 240
  start-page: 182
  year: 2001
  ident: 1765_CR161
  publication-title: Dev Biol
  doi: 10.1006/dbio.2001.0461
– volume: 296
  start-page: E603
  year: 2009
  ident: 1765_CR94
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.91002.2008
– volume: 630
  start-page: 103
  year: 1980
  ident: 1765_CR224
  publication-title: Biochim Biophys Acta
  doi: 10.1016/0304-4165(80)90141-5
– volume: 326
  start-page: 174
  year: 2005
  ident: 1765_CR184
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2004.11.015
– volume: 24
  start-page: 9
  year: 2014
  ident: 1765_CR189
  publication-title: Cell Res
  doi: 10.1038/cr.2013.169
– volume: 35
  start-page: C11
  year: 1967
  ident: 1765_CR46
  publication-title: J Cell Biol
  doi: 10.1083/jcb.35.2.C11
– volume: 15
  start-page: 81
  year: 2014
  ident: 1765_CR159
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm3735
– volume: 19
  start-page: 431
  year: 2014
  ident: 1765_CR57
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2014.02.010
– volume: 99
  start-page: 190
  year: 2002
  ident: 1765_CR242
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.012485299
– volume: 9
  start-page: 124
  year: 2013
  ident: 1765_CR265
  publication-title: Autophagy
  doi: 10.4161/auto.23323
– volume: 80
  start-page: 541
  year: 2002
  ident: 1765_CR177
  publication-title: Can J Physiol Pharmacol
  doi: 10.1139/y02-078
– volume: 215
  start-page: 449
  year: 1993
  ident: 1765_CR172
  publication-title: Eur J Biochem
  doi: 10.1111/j.1432-1033.1993.tb18053.x
– volume: 288
  start-page: 187
  year: 1980
  ident: 1765_CR225
  publication-title: Nature
  doi: 10.1038/288187a0
– volume: 25
  start-page: 193
  year: 2007
  ident: 1765_CR92
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2006.12.009
– volume: 334
  start-page: 261
  year: 1998
  ident: 1765_CR256
  publication-title: Biochem J
  doi: 10.1042/bj3340261
– volume: 20
  start-page: 5971
  year: 2001
  ident: 1765_CR241
  publication-title: EMBO J
  doi: 10.1093/emboj/20.21.5971
– volume: 294
  start-page: 1942
  year: 2001
  ident: 1765_CR61
  publication-title: Science
  doi: 10.1126/science.1066015
– volume: 10
  start-page: 356
  year: 2014
  ident: 1765_CR204
  publication-title: Autophagy
  doi: 10.4161/auto.26864
– volume: 274
  start-page: 11647
  year: 1999
  ident: 1765_CR118
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.17.11647
– volume: 9
  start-page: 1500
  year: 2013
  ident: 1765_CR258
  publication-title: Autophagy
  doi: 10.4161/auto.25573
– volume: 149
  start-page: 274
  year: 2012
  ident: 1765_CR135
  publication-title: Cell
  doi: 10.1016/j.cell.2012.03.017
– volume: 1
  start-page: 621
  year: 2013
  ident: 1765_CR85
  publication-title: Lancet Respir Med
  doi: 10.1016/S2213-2600(13)70183-8
– volume: 286
  start-page: 25477
  year: 2011
  ident: 1765_CR269
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.249631
– volume: 260
  start-page: 88
  year: 1993
  ident: 1765_CR219
  publication-title: Science
  doi: 10.1126/science.8385367
– volume: 9
  start-page: 850
  year: 2013
  ident: 1765_CR150
  publication-title: Autophagy
  doi: 10.4161/auto.24083
– volume: 13
  start-page: 215
  year: 2011
  ident: 1765_CR115
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2011.01.007
– volume: 13
  start-page: 514
  year: 2013
  ident: 1765_CR162
  publication-title: Curr Mol Med
  doi: 10.2174/1566524011313040005
– volume: 15
  start-page: 2962
  year: 2006
  ident: 1765_CR164
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddl239
– volume: 5
  start-page: 3
  year: 2009
  ident: 1765_CR167
  publication-title: Autophagy
  doi: 10.4161/auto.5.1.7207
– volume: 9
  start-page: 1983
  year: 2013
  ident: 1765_CR275
  publication-title: Autophagy
  doi: 10.4161/auto.26058
– volume: 37
  start-page: 232
  year: 2009
  ident: 1765_CR33
  publication-title: Biochem Soc Trans
  doi: 10.1042/BST0370232
– volume: 6
  start-page: 1017
  year: 2010
  ident: 1765_CR123
  publication-title: Autophagy
  doi: 10.4161/auto.6.8.13092
– volume: 267
  start-page: 5823
  year: 1992
  ident: 1765_CR171
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)42627-0
– volume: 31
  start-page: 1095
  year: 2012
  ident: 1765_CR227
  publication-title: EMBO J
  doi: 10.1038/emboj.2012.32
– volume: 50
  start-page: 353
  year: 2001
  ident: 1765_CR268
  publication-title: Diabetes
  doi: 10.2337/diabetes.50.2.353
– volume: 284
  start-page: 6322
  year: 2009
  ident: 1765_CR138
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M807135200
– volume: 288
  start-page: 21074
  year: 2013
  ident: 1765_CR183
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M113.456228
– volume: 243
  start-page: 240
  year: 1997
  ident: 1765_CR25
  publication-title: Eur J Biochem
  doi: 10.1111/j.1432-1033.1997.0240a.x
– volume: 24
  start-page: 69
  year: 2014
  ident: 1765_CR102
  publication-title: Cell Res
  doi: 10.1038/cr.2013.161
– volume: 37
  start-page: 111
  year: 2009
  ident: 1765_CR158
  publication-title: Amino Acids
  doi: 10.1007/s00726-008-0225-4
– volume: 8
  start-page: 931
  year: 2007
  ident: 1765_CR121
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm2245
– volume: 10
  start-page: 7
  year: 2012
  ident: 1765_CR37
  publication-title: Neurodegener Dis
  doi: 10.1159/000334283
– volume: 273
  start-page: 14484
  year: 1998
  ident: 1765_CR79
  publication-title: J Biol Chem
  doi: 10.1074/jbc.273.23.14484
– volume: 313
  start-page: 697
  year: 1996
  ident: 1765_CR82
  publication-title: Biochem J
  doi: 10.1042/bj3130697
– volume: 8
  start-page: 1875
  year: 2012
  ident: 1765_CR104
  publication-title: Autophagy
  doi: 10.4161/auto.21544
– volume: 465
  start-page: 942
  year: 2010
  ident: 1765_CR274
  publication-title: Nature
  doi: 10.1038/nature09076
– volume: 281
  start-page: 10214
  year: 2006
  ident: 1765_CR141
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M512792200
– volume: 458
  start-page: 1056
  year: 2009
  ident: 1765_CR29
  publication-title: Nature
  doi: 10.1038/nature07813
– volume: 78
  start-page: 152
  year: 1978
  ident: 1765_CR196
  publication-title: J Cell Biol
  doi: 10.1083/jcb.78.1.152
– volume: 276
  start-page: 38052
  year: 2001
  ident: 1765_CR249
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M106703200
– volume: 24
  start-page: 58
  year: 2014
  ident: 1765_CR231
  publication-title: Cell Res
  doi: 10.1038/cr.2013.159
– volume: 8
  start-page: 65
  year: 2003
  ident: 1765_CR120
  publication-title: Genes Cells
  doi: 10.1046/j.1365-2443.2003.00615.x
– volume: 23
  start-page: 53
  year: 2013
  ident: 1765_CR38
  publication-title: Curr Opin Genet Dev
  doi: 10.1016/j.gde.2012.12.005
– volume: 277
  start-page: 23977
  year: 2002
  ident: 1765_CR27
  publication-title: J Biol Chem
  doi: 10.1074/jbc.C200171200
– volume: 215
  start-page: 113
  year: 1993
  ident: 1765_CR89
  publication-title: Eur J Biochem
  doi: 10.1111/j.1432-1033.1993.tb18013.x
– volume: 15
  start-page: 741
  year: 2013
  ident: 1765_CR208
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb2757
– volume: 13
  start-page: 132
  year: 2011
  ident: 1765_CR114
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb2152
– volume: 20
  start-page: 507
  year: 2014
  ident: 1765_CR178
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2013.5359
– volume: 24
  start-page: 42
  year: 2014
  ident: 1765_CR209
  publication-title: Cell Res
  doi: 10.1038/cr.2013.166
– volume: 30
  start-page: 214
  year: 2008
  ident: 1765_CR73
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2008.03.003
– volume: 6
  start-page: 269
  year: 2000
  ident: 1765_CR47
  publication-title: Mol Cell
  doi: 10.1016/S1097-2765(00)00028-9
– volume: 25
  start-page: 657
  year: 2006
  ident: 1765_CR205
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1209106
– volume: 66
  start-page: 513
  year: 2012
  ident: 1765_CR137
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2012.09.003
– volume: 271
  start-page: 16668
  year: 1996
  ident: 1765_CR127
  publication-title: J Biol Chem
  doi: 10.1074/jbc.271.28.16668
– volume: 7
  start-page: 118
  year: 2011
  ident: 1765_CR131
  publication-title: Autophagy
  doi: 10.4161/auto.7.1.13697
– volume: 278
  start-page: 887
  year: 1991
  ident: 1765_CR12
  publication-title: Biochem J
  doi: 10.1042/bj2780887
– volume: 495
  start-page: 389
  year: 2013
  ident: 1765_CR77
  publication-title: Nature
  doi: 10.1038/nature11910
– volume: 272
  start-page: 21661
  year: 1997
  ident: 1765_CR86
  publication-title: J Biol Chem
  doi: 10.1074/jbc.272.35.21661
– volume: 269
  start-page: 3742
  year: 2002
  ident: 1765_CR129
  publication-title: Eur J Biochem
  doi: 10.1046/j.1432-1033.2002.03069.x
– volume: 107
  start-page: 207
  year: 1977
  ident: 1765_CR221
  publication-title: Exp Cell Res
  doi: 10.1016/0014-4827(77)90402-5
– volume: 147
  start-page: 728
  year: 2011
  ident: 1765_CR176
  publication-title: Cell
  doi: 10.1016/j.cell.2011.10.026
– volume: 275
  start-page: 29900
  year: 2000
  ident: 1765_CR179
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M003633200
– volume: 12
  start-page: 198
  year: 1962
  ident: 1765_CR7
  publication-title: J Cell Biol
  doi: 10.1083/jcb.12.1.198
– volume: 413
  start-page: 209
  year: 1989
  ident: 1765_CR134
  publication-title: Pflugers Arch
  doi: 10.1007/BF00583532
– volume: 80
  start-page: 125
  year: 2011
  ident: 1765_CR261
  publication-title: Annu Rev Biochem
  doi: 10.1146/annurev-biochem-052709-094552
– volume: 30
  start-page: 678
  year: 2008
  ident: 1765_CR260
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2008.06.001
– volume: 1824
  start-page: 51
  year: 2012
  ident: 1765_CR252
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbapap.2011.06.019
– volume: 80
  start-page: 1001
  year: 2011
  ident: 1765_CR112
  publication-title: Annu Rev Biochem
  doi: 10.1146/annurev-biochem-062209-094414
– volume: 100
  start-page: 914
  year: 2007
  ident: 1765_CR163
  publication-title: Circ Res
  doi: 10.1161/01.RES.0000261924.76669.36
– volume: 133
  start-page: 2052S
  year: 2003
  ident: 1765_CR107
  publication-title: J Nutr
  doi: 10.1093/jn/133.6.2052S
– volume: 334
  start-page: 678
  year: 2011
  ident: 1765_CR278
  publication-title: Science
  doi: 10.1126/science.1207056
– volume: 101
  start-page: 1519
  year: 1998
  ident: 1765_CR191
  publication-title: J Clin Invest
  doi: 10.1172/JCI1326
– volume: 35
  start-page: 900
  year: 2013
  ident: 1765_CR217
  publication-title: BioEssays
  doi: 10.1002/bies.201300064
– volume: 39
  start-page: 61
  year: 2014
  ident: 1765_CR230
  publication-title: Trends Biochem Sci
  doi: 10.1016/j.tibs.2013.12.001
– volume: 253
  start-page: 905
  year: 1991
  ident: 1765_CR84
  publication-title: Science
  doi: 10.1126/science.1715094
– volume: 5
  start-page: 427
  year: 2013
  ident: 1765_CR122
  publication-title: J Innate Immun
  doi: 10.1159/000351979
– volume: 122
  start-page: 927
  year: 2005
  ident: 1765_CR192
  publication-title: Cell
  doi: 10.1016/j.cell.2005.07.002
– volume: 351
  start-page: 545
  year: 2000
  ident: 1765_CR255
  publication-title: Biochem J
  doi: 10.1042/0264-6021:3510545
– volume: 265
  start-page: 955
  year: 1990
  ident: 1765_CR11
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(19)40142-7
– volume: 42
  start-page: 2507
  year: 2012
  ident: 1765_CR244
  publication-title: Amino Acids
  doi: 10.1007/s00726-011-0981-4
– volume: 47
  start-page: 851
  year: 2012
  ident: 1765_CR259
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2012.08.001
– volume: 137
  start-page: 191
  year: 1982
  ident: 1765_CR126
  publication-title: Exp Cell Res
  doi: 10.1016/0014-4827(82)90020-9
– volume: 277
  start-page: 34826
  year: 2002
  ident: 1765_CR136
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M205028200
– volume: 6
  start-page: 458
  year: 2007
  ident: 1765_CR156
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2007.11.001
– volume: 285
  start-page: E854
  year: 2003
  ident: 1765_CR154
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00153.2003
– volume: 129
  start-page: 1261
  year: 2007
  ident: 1765_CR157
  publication-title: Cell
  doi: 10.1016/j.cell.2007.06.009
– volume: 18
  start-page: 524
  year: 2012
  ident: 1765_CR54
  publication-title: Trends Mol Med
  doi: 10.1016/j.molmed.2012.05.007
– volume: 52
  start-page: 495
  year: 2013
  ident: 1765_CR250
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2013.09.016
– volume: 203
  start-page: 563
  year: 2013
  ident: 1765_CR18
  publication-title: J Cell Biol
  doi: 10.1083/jcb.201306041
– volume: 279
  start-page: 8452
  year: 2004
  ident: 1765_CR108
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M306337200
– volume: 24
  start-page: 92
  year: 2014
  ident: 1765_CR41
  publication-title: Cell Res
  doi: 10.1038/cr.2013.153
– volume: 280
  start-page: 23433
  year: 2005
  ident: 1765_CR148
  publication-title: J Biol Chem
  doi: 10.1074/jbc.C500169200
– volume: 219
  start-page: 455
  year: 1987
  ident: 1765_CR140
  publication-title: FEBS Lett
  doi: 10.1016/0014-5793(87)80271-5
– volume: 37
  start-page: 633
  year: 2010
  ident: 1765_CR270
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2010.01.031
– volume: 21
  start-page: 4347
  year: 2001
  ident: 1765_CR185
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.21.13.4347-4368.2001
– volume: 284
  start-page: 8023
  year: 2009
  ident: 1765_CR247
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M900301200
– volume: 1
  start-page: e12
  year: 2010
  ident: 1765_CR22
  publication-title: Cell Death Dis
  doi: 10.1038/cddis.2009.17
– volume: 27
  start-page: 19
  year: 2007
  ident: 1765_CR175
  publication-title: Annu Rev Nutr
  doi: 10.1146/annurev.nutr.27.061406.093749
– volume: 2
  start-page: e690
  year: 2007
  ident: 1765_CR155
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0000690
– volume: 22
  start-page: 508
  year: 1994
  ident: 1765_CR151
  publication-title: Biochem Soc Trans
  doi: 10.1042/bst0220508
– volume: 29
  start-page: 365
  year: 1997
  ident: 1765_CR24
  publication-title: Histochem J
  doi: 10.1023/A:1026486801018
– volume: 25
  start-page: 1171
  year: 2014
  ident: 1765_CR103
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.E14-01-0021
– volume: 24
  start-page: 24
  year: 2014
  ident: 1765_CR63
  publication-title: Cell Res
  doi: 10.1038/cr.2013.168
– volume: 10
  start-page: 339
  year: 2014
  ident: 1765_CR80
  publication-title: Autophagy
  doi: 10.4161/auto.26863
– volume: 320
  start-page: 1496
  year: 2008
  ident: 1765_CR211
  publication-title: Science
  doi: 10.1126/science.1157535
– volume: 519
  start-page: 69
  year: 2012
  ident: 1765_CR144
  publication-title: Arch Biochem Biophys
  doi: 10.1016/j.abb.2011.10.015
– volume: 110
  start-page: 12526
  year: 2013
  ident: 1765_CR19
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1302455110
– volume: 372
  start-page: 555
  year: 2003
  ident: 1765_CR20
  publication-title: Biochem J
  doi: 10.1042/bj20021266
– volume: 11
  start-page: 4107
  year: 2012
  ident: 1765_CR50
  publication-title: Cell Cycle
  doi: 10.4161/cc.22632
– volume: 452
  start-page: 181
  year: 2009
  ident: 1765_CR21
  publication-title: Methods Enzymol
  doi: 10.1016/S0076-6879(08)03612-4
– volume: 115
  start-page: 577
  year: 2003
  ident: 1765_CR96
  publication-title: Cell
  doi: 10.1016/S0092-8674(03)00929-2
– volume: 273
  start-page: 3963
  year: 1998
  ident: 1765_CR188
  publication-title: J Biol Chem
  doi: 10.1074/jbc.273.7.3963
– volume: 281
  start-page: 27643
  year: 2006
  ident: 1765_CR216
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M603536200
– volume: 53
  start-page: 89
  year: 2013
  ident: 1765_CR229
  publication-title: Annu Rev Pharmacol Toxicol
  doi: 10.1146/annurev-pharmtox-010611-134717
– volume: 24
  start-page: 73
  year: 2014
  ident: 1765_CR237
  publication-title: Trends Cell Biol
  doi: 10.1016/j.tcb.2013.07.008
– volume: 279
  start-page: 54103
  year: 2004
  ident: 1765_CR119
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M410755200
– volume: 431
  start-page: 200
  year: 2004
  ident: 1765_CR253
  publication-title: Nature
  doi: 10.1038/nature02866
– volume: 20
  start-page: 1992
  year: 2009
  ident: 1765_CR105
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.E08-12-1249
– volume: 284
  start-page: 12297
  year: 2009
  ident: 1765_CR67
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M900573200
– volume: 447
  start-page: 303
  year: 1999
  ident: 1765_CR233
  publication-title: FEBS Lett
  doi: 10.1016/S0014-5793(99)00304-X
– volume: 152
  start-page: 290
  year: 2013
  ident: 1765_CR116
  publication-title: Cell
  doi: 10.1016/j.cell.2012.12.016
– ident: 1765_CR55
  doi: 10.1016/j.devcel.2014.03.017
– volume: 9
  start-page: e87161
  year: 2014
  ident: 1765_CR277
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0087161
– volume: 20
  start-page: 443
  year: 2014
  ident: 1765_CR201
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2013.5410
– volume: 141
  start-page: 290
  year: 2010
  ident: 1765_CR212
  publication-title: Cell
  doi: 10.1016/j.cell.2010.02.024
– ident: 1765_CR58
  doi: 10.1126/scisignal.2000911
– volume: 4
  start-page: 006
  year: 2012
  ident: 1765_CR69
  publication-title: J Clin Exp Pathol Suppl
– volume: 280
  start-page: 18717
  year: 2005
  ident: 1765_CR235
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M414499200
– volume: 141
  start-page: 705
  year: 2013
  ident: 1765_CR98
  publication-title: J Gen Physiol
  doi: 10.1085/jgp.201210930
– volume: 23
  start-page: 301
  year: 2013
  ident: 1765_CR264
  publication-title: Semin Cancer Biol
  doi: 10.1016/j.semcancer.2013.05.007
– volume: 21
  start-page: R227
  year: 2011
  ident: 1765_CR170
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2011.02.007
– volume: 36
  start-page: 1691
  year: 1977
  ident: 1765_CR195
  publication-title: Acta Biol Med Ger
– volume: 36
  start-page: 30
  year: 2011
  ident: 1765_CR214
  publication-title: Trends Biochem Sci
  doi: 10.1016/j.tibs.2010.07.007
– volume: 38
  start-page: 1533
  year: 2010
  ident: 1765_CR8
  publication-title: Amino Acids
  doi: 10.1007/s00726-009-0377-x
– volume: 14
  start-page: 829
  year: 2012
  ident: 1765_CR254
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb2536
– volume: 11
  start-page: 709
  year: 2012
  ident: 1765_CR206
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/nrd3802
– volume: 76
  start-page: 3169
  year: 1979
  ident: 1765_CR220
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.76.7.3169
– volume: 136
  start-page: 521
  year: 2009
  ident: 1765_CR186
  publication-title: Cell
  doi: 10.1016/j.cell.2008.11.044
SSID ssj0012816
Score 2.4979622
SecondaryResourceType review_article
Snippet Amino acids not only participate in intermediary metabolism but also stimulate insulin-mechanistic target of rapamycin (MTOR)-mediated signal transduction...
SourceID pubmedcentral
proquest
pubmed
crossref
springer
fao
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 2037
SubjectTerms Amino acids
Amino Acids - metabolism
Analytical Chemistry
Animals
Autophagy
Biochemical Engineering
biochemical pathways
Biochemistry
Biomedical and Life Sciences
Cell survival
cell viability
Control
etiology
Humans
Life Sciences
Metabolic pathways
Metabolism
Neurobiology
Organelles
Pathology
Pathways
proteins
Proteomics
Rapamycin
Redundant
Review
Review Article
Signal Transduction
Stimulation
Survival
TOR protein
TOR Serine-Threonine Kinases - metabolism
SummonAdditionalLinks – databaseName: SpringerLink Journals (ICM)
  dbid: U2A
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LaxRBEG5MPOhFfGc1SguelIGZfs8xBEMQViFmIbehn3HBzIg7e8i_t6rngatJwHPX9PR8_aqaqvqKkPe18iLYMoCRI1whQAUorEqmiMlEyVLQKf_vWH5Rpyvx-UJejHncmynafXJJ5pN6TnZDkmu0fgWSGspC7JH7Ekx3jONasaPZdcBMrncKlnpdIPvW5Mq8qYudy2gv2e4mPfPfcMm_fKb5Kjp5TB6NOiQ9Gib9CbkX26fkwfFUuu0ZWZ4NFeYBc9olarfIHmAvr6m7pvZq3XbU-nXYUNsGujz_elZMpXB7ivEc0HePV1gYmGWfk9XJp_Pj02Ksm1B4Jeu-EL6KgWnGQ-UZV7FyUSbHbe2MDkmWgXkdjVJOalBvbKnAZhHB8BBMSGWZ-Auy33ZtPCDUWu-roDhDzp-UTJ0c5q6KqJ1mzMoFKScAGz-SimNtix_NTIecMW8A8wYxb8SCfJgf-TkwatwlfACz0thLOPGa1TeGfHg535fDqw-nqWrGfbeBpyqwfzir-IK8m5sBfXSD2DZ22yyj0Pur2V0yioEyBYO5XQaTnJBLwIDMy2GFzB_E8Fysy3pB9M7amQWQ1Xu3pV1_z-zeQhoAAcb2cVplf3zebTi9-i_p1-QhICmHmMRDst__2sY3oFv17m3eS78Be08YpQ
  priority: 102
  providerName: Springer Nature
Title Regulation of autophagy by amino acids and MTOR-dependent signal transduction
URI https://link.springer.com/article/10.1007/s00726-014-1765-4
https://www.ncbi.nlm.nih.gov/pubmed/24880909
https://www.proquest.com/docview/1715853213
https://www.proquest.com/docview/1716935872
https://www.proquest.com/docview/1762075726
https://www.proquest.com/docview/2000025486
https://pubmed.ncbi.nlm.nih.gov/PMC4580722
Volume 47
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bb9MwFLbY9gAviPvKxhQknkARieNbnlCp2k2gDlRWqTxFji-jEiRjbR_27znHuUCB9SWR4pPE_nxsH_vY3yHkVS4MszqxMMlhZczABIi18Cp2XjlOvZU-rHdMz8XZnH1Y8EW74LZqt1V2fWLoqG1tcI38bSpTsGwzmmbvrn7GGDUKvattCI09coDUZajVctFPuNBJFHyVOXo7GU87r2YSSEQlxbk0Q4pEHrOtcWnP6_p_Jue_Oyf_cp-GUWnygNxvzclo2NT_Q3LHVY_I3VEXxe0xmc6aYPMAf1T7SG-QSEBf3kTlTaR_LKs60mZpV5GubDS9-DSLu6i46wi3dsC31zia2YZk9gmZT8YXo7O4DaEQG8HzdcxM6iyVNLOpoZlwaem4LzOdl0pazxNLjXRKiJJLsHR0ImD6wqzKrFXWJ4nPnpL9qq7cIYm0Nia1IqNI_-O9yn2Jx1iZk6WkVPMBSToAC9Pyi2OYi-9Fz4wcMC8A8wIxL9iAvO5fuWrINXYJH0KtFPoSOr9i_oUiNV44-pvBr4-7qiraJrgqfivMgLzskwF99IjoytWbICPQESzpLhlBwa6CzNwug-edkFZAgcyzRkP6AlHsIvMkHxC5pTu9ABJ8b6dUy2-B6JtxBSBA3t50WvZH8W7D6fluMI7IPYCON_sRj8n--nrjXoBdtS5PQuOBq5qcnpCD4enXj2O4vx-ff57B05EYwXVOh78AUNIh8g
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF615VAuiHdTCiwSXEAW9j7tA0KoEFLaFKkkUm9mvY8SidqFJEL5U_xGZuzYEKC59ezxev3t7M7szs43hDzNlBXOxA42OaKIBLgAkVEhjXxIvWTB6VCfdwyP1WAsPpzK0w3ys82FwWuV7ZpYL9SusnhG_jLRCXi2nCX89cW3CKtGYXS1LaHRqMWhX_yALdv01cFbGN9njPXfjfYH0bKqQGSVzGaRsIl3TDPuEsu48knhZSi4yYpUuyBjx6z2qVKF1GD8TazAoxcu5c6lLsRx4NDuJrkmOFhyzEzvv--iFiytS63GGUZXhUzaKGpck5Zqhnt3gZSMMhIrdnAzmOp_Lu6_NzX_CtfWVrB_k9xYuq_0TaNvt8iGL2-T7f22atwdMjxpitvDcNMqUDNH4gJztqDFgprzSVlRYyduSk3p6HD08SRqq_DOKF4lgbZnaD1dQ2p7l4yvBNx7ZKusSr9DqDHWJk5xhnRDIaRZKDBtVnhdaMaM7JG4BTC3Sz5zLKvxNe-YmGvMc8A8R8xz0SPPu1cuGjKPdcI7MCq5OYPFNh9_YkjFV6cac_j0XjtU-XLKT_PfCtojT7rHgD5GYEzpq3ktozDwrNk6GcXAj4POXC6D-VVIY5CCzP1GQ7ofYrgkZ3HWI3pFdzoBJBRffVJOvtTE4kKmAAL07UWrZX_83mU47a4H4zHZHoyGR_nRwfHhA3IdYJTNXcg9sjX7PvcPwaebFY_qiUTJ56ueub8AiYhZMg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELbarQRcEO9uKWAkuICiJo4fyQEhaLtqKbtUS1fqLXViu6xEk8Jmhfav8euYyQsW6N56zsRxPo_HY8_4G0JexDLjRvsGNjk89Ti4AJ6WLvKsi6xgzihXnXcMR_Jgwj-citM18rO9C4Npla1NrAy1KTI8I98JVACebciCcMc1aRHHe4O3l988rCCFkda2nEatIkd28QO2b7M3h3sw1i8ZG-yf7B54TYUBL5MiLj2eBdYwxUITZCyUNkitcGmo4zRSxgnfsEzZSMpUKHAEtC_Bu-cmCo2JjPN9F0K762RD4a6oRzbe74-Ox10Mg0VV4VU_xlgrF0EbU_UrClPFcCfPkaBReHxpVVx3uvifw_tv3uZfwdtqTRzcIbcbZ5a-q7XvLlmz-T1yc7etIXefDMd1qXsYfFo4qudIY6DPFzRdUH0xzQuqs6mZUZ0bOjz5NPbamrwlxcQSaLvEtdTUFLcPyORa4H1IenmR201Ctc6ywMiQIfmQc1HsUrxEy61KFWNa9InfAphkDbs5Ftn4mnS8zBXmCWCeIOYJ75NX3SuXNbXHKuFNGJVEn4PpTSafGRLzVRePQ_j0djtUSWMAZslvde2T591jQB_jMTq3xbySkRiGVmyVjGTg1UFnrpbB21ZIahCBzKNaQ7ofYmigYz_uE7WkO50A0osvP8mnXyqacS4iAAH69rrVsj9-7yqctlaD8YzcgFmbfDwcHT0mtwBFUSdGbpNe-X1un4CDV6ZPm5lEydl1T95ftjtexA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Regulation+of+autophagy+by+amino+acids+and+MTOR-dependent+signal+transduction&rft.jtitle=Amino+acids&rft.au=Meijer%2C+Alfred+J&rft.au=Lorin%2C+S%C3%A9verine&rft.au=Blommaart%2C+Edward+F&rft.au=Codogno%2C+Patrice&rft.date=2015-10-01&rft.pub=Springer+Vienna&rft.issn=0939-4451&rft.eissn=1438-2199&rft.volume=47&rft.issue=10&rft.spage=2037&rft.epage=2063&rft_id=info:doi/10.1007%2Fs00726-014-1765-4&rft.externalDocID=US201600012035
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0939-4451&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0939-4451&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0939-4451&client=summon