Pattern of Diagnostic Evaluation for the Causes of Pediatric Acute Liver Failure: An Opportunity for Quality Improvement

• Published in: The Journal of pediatrics Vol. 155; no. 6; pp. 801 - 806.e1
• Main Authors: Narkewicz, Michael R., MD, Dell Olio, Dominic, MD, Karpen, Saul J., MD, PhD, Murray, Karen F., MD, Schwarz, Kathy, MD, Yazigi, Nada, MD, Zhang, Song, MS, Belle, Steven H., PhD, MScHyg, Squires, Robert H., MD
• Format: Journal Article
• Language: English
• Published: Maryland Heights, MO Mosby, Inc 01.12.2009; Elsevier
• Subjects: Adolescent; Age Factors; Biological and medical sciences; Canada; Child; Child, Preschool; Cohort Studies; Databases, Factual; Female; Gastroenterology. Liver. Pancreas. Abdomen; General aspects; Humans; Infant; Liver Failure, Acute - diagnosis; Liver Failure, Acute - etiology; Liver Failure, Acute - therapy; Liver Function Tests - utilization; Liver Transplantation; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Other diseases. Semiology; Pediatrics; Quality of Health Care; Retrospective Studies; Risk Factors; United Kingdom; United States; AIH; Fatty acid oxidation; Acute liver failure; Pediatric acute liver failure; Anti-nuclear antibody; Epstein Barr virus; HSV; Herpes simplex virus; PALF; LKM; Liver kidney microsomal antibody; Autoimmune hepatitis; ANA; FAO; Galactose-1-phosphate uridyltransferase; ASMA; EBV; Gal-1-PUT; ALF; Hepatitis B virus; Anti-smooth muscle antibody; HBV; Human; Evaluation; Pediatrics; Improvement; Liver failure; Acute; Quality; Cause; Digestive diseases; Hepatic disease; Diagnosis; Child

Objective To describe the frequency of diagnostic testing for the 4 most common causes of pediatric acute liver failure (PALF) (drugs, metabolic disease, autoimmune process, and infections) in indeterminate PALF within the PALF Study Group Database. Study design PALF was defined by severe hepatic dy...