The transcription factor TCF-1 enforces commitment to the innate lymphoid cell lineage

• Published in: Nature immunology Vol. 20; no. 9; pp. 1150 - 1160
• Main Authors: Harly, Christelle, Kenney, Devin, Ren, Gang, Lai, Binbin, Raabe, Tobias, Yang, Qi, Cam, Margaret C., Xue, Hai-Hui, Zhao, Keji, Bhandoola, Avinash
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.09.2019; Nature Publishing Group
• Subjects: 631/250/232; 631/250/2502; 631/250/2504; Animals; Biomedical and Life Sciences; Biomedicine; Cancer; Cell Differentiation - immunology; Cell lineage; Cell Lineage - immunology; Cells, Cultured; Chromatin; Cytokines; Dendritic cells; Dendritic Cells - cytology; Developmental stages; Gene Expression Regulation - genetics; Granulocytes; Hepatocyte nuclear factor 1; Hepatocyte Nuclear Factor 1-alpha - genetics; Hepatocyte Nuclear Factor 1-alpha - immunology; Heterogeneity; Homeostasis; Immunology; Infectious Diseases; Life Sciences; Lymphocytes; Lymphocytes T; Lymphoid cells; Lymphoid Progenitor Cells - cytology; Medical research; Medicine; Mice; Mice, Inbred C57BL; RNA sequencing; T cells; T-Lymphocytes - cytology; Transcription factors; Transcription, Genetic - genetics

Innate lymphoid cells (ILCs) play important functions in immunity and tissue homeostasis, but their development is poorly understood. Through the use of single-cell approaches, we examined the transcriptional and functional heterogeneity of ILC progenitors, and studied the precursor–product relation...