Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder

• Published in: Brain, behavior, and immunity Vol. 49; pp. 206 - 215
• Main Authors: Haapakoski, Rita, Mathieu, Julia, Ebmeier, Klaus P., Alenius, Harri, Kivimäki, Mika
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.10.2015; Academic Press
• Subjects: Adult; Allergy and Immunology; C-reactive protein; C-Reactive Protein - immunology; C-Reactive Protein - metabolism; Cumulative meta-analysis; Depressive Disorder, Major - blood; Depressive Disorder, Major - complications; Depressive Disorder, Major - immunology; Female; Humans; Inflammation; Inflammation - blood; Inflammation - complications; Inflammation - immunology; Inflammation Mediators - blood; Inflammation Mediators - immunology; Interleukin-1beta - blood; Interleukin-1beta - immunology; Interleukin-1β; Interleukin-6; Interleukin-6 - blood; Interleukin-6 - immunology; Major depression; Male; Psychiatry; Tumor Necrosis Factor-alpha - blood; Tumor Necrosis Factor-alpha - immunology; Tumour necrosis factor-α; Tumour necrosis factor-α; C-reactive protein; Major depression; Interleukin-1β; Inflammation; Cumulative meta-analysis; Interleukin-6

•This meta-analysis confirms a robust link between IL-6, CRP and major depression.•The role of TNF-α and IL-1β in major depression remains uncertain.•Further mechanistic and immunotherapeutic studies on IL-6 and CRP are needed. Cumulative meta-analyses are used to evaluate the extent to which furthe...