Fast-evolving noncoding sequences in the human genome

• Published in: Genome biology Vol. 8; no. 6; p. R118
• Main Authors: Bird, Christine P, Stranger, Barbara E, Liu, Maureen, Thomas, Daryl J, Ingle, Catherine E, Beazley, Claude, Miller, Webb, Hurles, Matthew E, Dermitzakis, Emmanouil T
• Format: Journal Article
• Language: English
• Published: England BioMed Central 19.06.2007
• Subjects: alleles; Animals; Base Sequence; Conserved Sequence; DNA; evolution; Evolution, Molecular; gene expression; Gene Expression Regulation; Genome; Genome, Human; human population; Humans; Macaca; nucleotide sequences; Pan troglodytes; phenotype; phenotypic variation; Polymorphism, Single Nucleotide; probability; Regulatory Sequences, Nucleic Acid; Selection, Genetic; Sequence Analysis, DNA; single nucleotide polymorphism

Gene regulation is considered one of the driving forces of evolution. Although protein-coding DNA sequences and RNA genes have been subject to recent evolutionary events in the human lineage, it has been hypothesized that the large phenotypic divergence between humans and chimpanzees has been driven...