A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers

• Published in: PloS one Vol. 9; no. 4; p. e93046
• Main Authors: Goonesekere, Nalin C W, Wang, Xiaosheng, Ludwig, Lindsey, Guda, Chittibabu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2014; Public Library of Science (PLoS)
• Subjects: Biochemistry; Biology; Biology and Life Sciences; Biomarkers; Breast cancer; Cancer; Cancer survivors; Carcinoma; Care and treatment; CpG Islands; Datasets; Deoxyribonucleic acid; Diagnostic systems; DNA; DNA Methylation; DNA microarrays; Epigenetics; Gene expression; Gene Expression Regulation, Neoplastic; Gene families; Gene Regulatory Networks; Genes; Genetic aspects; Genetic Markers; Genetics; Genomes; Genomics; Health aspects; Immune response; Immune system; Kinases; Medical research; Medicine and Health Sciences; Meta-analysis; Metastases; Metastasis; Mutation; Oligonucleotide Array Sequence Analysis; Pancreatic cancer; Pancreatic Neoplasms - genetics; Promoter Regions, Genetic; Protein kinase; Proteins; Research and Analysis Methods; Studies; Up-Regulation; United States > US; Iowa; Nebraska

The lack of specific symptoms at early tumor stages, together with a high biological aggressiveness of the tumor contribute to the high mortality rate for pancreatic cancer (PC), which has a five year survival rate of less than 5%. Improved screening for earlier diagnosis, through the detection of d...