Hemagglutinin–neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. 34; pp. 14264 - 14269
• Main Authors: Yen, Hui-Ling, Liang, Chi-Hui, Wu, Chung-Yi, Forrest, Heather L, Ferguson, Angela, Choy, Ka-Tim, Jones, Jeremy, Wong, Diana Dik-Yan, Cheung, Peter Pak-Hang, Hsu, Che-Hsiung, Li, Olive T, Yuen, Kit M, Chan, Renee W. Y, Poon, Leo L. M, Chan, Michael C. W, Nicholls, John M, Krauss, Scott, Wong, Chi-Huey, Guan, Yi, Webster, Robert G, Webby, Richard J, Peiris, Malik
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 23.08.2011; National Acad Sciences
• Subjects: Amino acids; Animals; Biological Sciences; Cells; China; direct contact; Disease transmission; double prime M gene; Enzymatic activity; enzyme activity; Enzymes; Epithelial cells; Exo- alpha -sialidase; ferrets; Ferrets - virology; genes; Genome, Viral - genetics; H1N1 subtype influenza A virus; Hemagglutinin Glycoproteins, Influenza Virus - metabolism; humans; Influenza; Influenza A virus; Influenza A Virus, H1N1 Subtype - enzymology; Influenza A Virus, H1N1 Subtype - genetics; Influenza A Virus, H1N1 Subtype - physiology; Influenza virus; Kinetics; Life Sciences; Microbiology and Parasitology; monitoring; Mustela; Neuraminidase - metabolism; nose; Orthomyxoviridae; Orthomyxoviridae Infections - epidemiology; Orthomyxoviridae Infections - transmission; Orthomyxoviridae Infections - virology; pandemic; Pandemics; Polysaccharides; Polysaccharides - metabolism; Protein Binding; Receptors; Receptors, Virus - metabolism; Recombination, Genetic - genetics; Replication; Respiratory System - pathology; Respiratory System - virology; Seasons; sialidase; Substrate Specificity; Swine; Swine flu; Swine influenza; Transmission efficiency; Tropism; Virology; virus replication; Virus Replication - physiology; Viruses; China

A novel reassortant derived from North American triple-reassortant (TRsw) and Eurasian swine (EAsw) influenza viruses acquired sustained human-to-human transmissibility and caused the 2009 influenza pandemic. To identify molecular determinants that allowed efficient transmission of the pandemic H1N1...