Landscape of nuclear transport receptor cargo specificity

• Published in: Molecular systems biology Vol. 13; no. 12; pp. 962 - n/a
• Main Authors: Mackmull, Marie‐Therese, Klaus, Bernd, Heinze, Ivonne, Chokkalingam, Manopriya, Beyer, Andreas, Russell, Robert B, Ori, Alessandro, Beck, Martin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2017; EMBO Press; John Wiley and Sons Inc; Springer Nature
• Subjects: Active Transport, Cell Nucleus; Biotin; Biotinylation; Cargo; Cell Nucleus - metabolism; EMBO17; EMBO26; EMBO31; Gene Ontology; Humans; interaction network; Interfaces; Localization; Mass spectrometry; Mass spectroscopy; Mutation - genetics; Nuclear Localization Signals; nuclear pore complex; Nuclear transport; Peptide mapping; Peptides; Peptides - metabolism; Protein Binding; Protein Subunits - metabolism; Protein transport; Proteome - metabolism; Proteomes; proteomics; proximity ligation; Receptors; Receptors, Cytoplasmic and Nuclear - metabolism; Redundancy; Reproducibility of Results; RNA, Small Interfering - metabolism; Statistics as Topic; Subcellular Fractions - metabolism; Transport; protein transport; nuclear pore complex; interaction network; proteomics; proximity ligation

Nuclear transport receptors (NTRs) recognize localization signals of cargos to facilitate their passage across the central channel of nuclear pore complexes (NPCs). About 30 different NTRs constitute different transport pathways in humans and bind to a multitude of different cargos. The exact cargo...